(74 nodes) Disease network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6Q2U2_CIOIN	CNH domain-containing protein. (871 aa)
	F6QRK3_CIOIN	Uncharacterized protein. (248 aa)
	F7BBV8_CIOIN	CNH domain-containing protein. (856 aa)
	F6VII8_CIOIN	tRNA-synt_1e domain-containing protein. (251 aa)
	neuralized-a	Ci-Neuralized-a protein. (544 aa)
	LOC100177361	Uncharacterized protein. (710 aa)
	E(spl)/hairy-b	Uncharacterized protein. (333 aa)
	F6ZQI8_CIOIN	Uncharacterized protein; Belongs to the glycosyl hydrolase 31 family. (384 aa)
	LOC100187036	NIPA-like protein. (405 aa)
	F6YNT4_CIOIN	Coronin; Belongs to the WD repeat coronin family. (925 aa)
	F6YG81_CIOIN	CASP_C domain-containing protein. (655 aa)
	E(spl)/hairy-c	Uncharacterized protein. (522 aa)
	H2XXD3_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. (314 aa)
	LOC100185122	Uncharacterized protein. (863 aa)
	F6ZE72_CIOIN	MFS domain-containing protein. (227 aa)
	Ci-ZF(ZZ)-7	Zinc finger protein. (619 aa)
	F6ZBA8_CIOIN	Glyco_hydro_63 domain-containing protein. (466 aa)
	F6XU15_CIOIN	Uncharacterized protein. (687 aa)
	elk	Transcription factor protein. (946 aa)
	F6PPA8_CIOIN	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1114 aa)
	F7AJ84_CIOIN	Gal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (932 aa)
	F6PKS2_CIOIN	Uncharacterized protein. (452 aa)
	LOC100181376	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (463 aa)
	LOC100183132	Uncharacterized protein. (740 aa)
	H2XX93_CIOIN	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (468 aa)
	H2XX14_CIOIN	Uncharacterized protein. (116 aa)
	H2XV52_CIOIN	Uncharacterized protein. (225 aa)
	H2XRI7_CIOIN	Uncharacterized protein. (161 aa)
	H2XR78_CIOIN	Uncharacterized protein. (230 aa)
	H2XQL8_CIOIN	OTU domain-containing protein. (189 aa)
	H2XQ42_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (266 aa)
	H2XPM9_CIOIN	Uncharacterized protein. (209 aa)
	H2XN51_CIOIN	Uncharacterized protein. (2009 aa)
	LOC100186755	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (598 aa)
	H2XK36_CIOIN	PWWP domain-containing protein. (443 aa)
	H2XJG1_CIOIN	RING-type domain-containing protein. (147 aa)
	LOC100175281	Uncharacterized protein. (857 aa)
	F6Z0E6_CIOIN	KH domain-containing protein. (136 aa)
	LOC100178170	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (919 aa)
	Zf(c2h2)-80	Uncharacterized protein. (698 aa)
	F6YU56_CIOIN	Uncharacterized protein. (351 aa)
	F6YX11_CIOIN	Uncharacterized protein. (435 aa)
	F6V542_CIOIN	Uncharacterized protein. (159 aa)
	F6UG73_CIOIN	Uncharacterized protein. (434 aa)
	LOC100180498	Uncharacterized protein. (483 aa)
	F6WQL4_CIOIN	BZIP domain-containing protein. (312 aa)
	F6XC92_CIOIN	Importin N-terminal domain-containing protein. (1110 aa)
	LOC100183193	Non-canonical poly(A) RNA polymerase PAPD5. (391 aa)
	F7ATN8_CIOIN	RanBD1 domain-containing protein. (211 aa)
	LOC100186610	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (114 aa)
	H2XYC7_CIOIN	Uncharacterized protein. (197 aa)
	F6Z932_CIOIN	Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family. (230 aa)
	LOC100176140	KN motif and ankyrin repeat domain-containing protein 1-like isoform X1. (1238 aa)
	F6TX56_CIOIN	Tr-type G domain-containing protein. (428 aa)
	F6YSQ6_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (315 aa)
	LOC100184811	VWFA domain-containing protein. (243 aa)
	LOC113473984	Protein cereblon homolog. (169 aa)
	F6Z411_CIOIN	Uncharacterized protein. (426 aa)
	F6S3Q7_CIOIN	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (630 aa)
	LOC100184003	Importin subunit alpha; Belongs to the importin alpha family. (519 aa)
	F7AGW4_CIOIN	Importin N-terminal domain-containing protein. (1021 aa)
	LOC100187236	Uncharacterized protein. (468 aa)
	neuralized-b	Neuralized-b protein isoform X1. (569 aa)
	F6Z833_CIOIN	Uncharacterized protein. (250 aa)
	LOC100180059	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (626 aa)
	F6SZ37_CIOIN	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (844 aa)
	LOC100180827	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (400 aa)
	F6XBC5_CIOIN	Protein kinase domain-containing protein. (656 aa)
	H2Y2F9_CIOIN	Protein kinase domain-containing protein. (249 aa)
	H2Y0Y4_CIOIN	Coronin; Belongs to the WD repeat coronin family. (210 aa)
	H2Y0N1_CIOIN	Uncharacterized protein. (179 aa)
	H2Y094_CIOIN	Uncharacterized protein. (57 aa)
	H2Y025_CIOIN	Uncharacterized protein. (384 aa)
	LOC100175549	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (533 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ci-ZF(ZZ)-7	H2XJG1_CIOIN	ENSCINP00000001354	ENSCINP00000029793	Zinc finger protein.	RING-type domain-containing protein.	0.895
F6PPA8_CIOIN	H2XR78_CIOIN	ENSCINP00000004713	ENSCINP00000032162	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.917
F6Q2U2_CIOIN	F6SZ37_CIOIN	ENSCINP00000013314	ENSCINP00000014316	CNH domain-containing protein.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.995
F6Q2U2_CIOIN	F6YU56_CIOIN	ENSCINP00000013314	ENSCINP00000026122	CNH domain-containing protein.	Uncharacterized protein.	0.914
F6Q2U2_CIOIN	F7BBV8_CIOIN	ENSCINP00000013314	ENSCINP00000011601	CNH domain-containing protein.	CNH domain-containing protein.	0.947
F6Q2U2_CIOIN	H2XX14_CIOIN	ENSCINP00000013314	ENSCINP00000034198	CNH domain-containing protein.	Uncharacterized protein.	0.914
F6Q2U2_CIOIN	LOC100180059	ENSCINP00000013314	ENSCINP00000014583	CNH domain-containing protein.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.927
F6Q2U2_CIOIN	LOC100185122	ENSCINP00000013314	ENSCINP00000000564	CNH domain-containing protein.	Uncharacterized protein.	0.994
F6Q2U2_CIOIN	LOC100186755	ENSCINP00000013314	ENSCINP00000030562	CNH domain-containing protein.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.970
F6S3Q7_CIOIN	F6XU15_CIOIN	ENSCINP00000018514	ENSCINP00000003935	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Uncharacterized protein.	0.966
F6S3Q7_CIOIN	LOC100177361	ENSCINP00000018514	ENSCINP00000010932	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Uncharacterized protein.	0.997
F6S3Q7_CIOIN	LOC100180498	ENSCINP00000018514	ENSCINP00000023795	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Uncharacterized protein.	0.537
F6S3Q7_CIOIN	LOC100181376	ENSCINP00000018514	ENSCINP00000007028	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	0.999
F6S3Q7_CIOIN	LOC100183132	ENSCINP00000018514	ENSCINP00000007386	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Uncharacterized protein.	0.917
F6S3Q7_CIOIN	LOC100186610	ENSCINP00000018514	ENSCINP00000023292	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]	0.999
F6SZ37_CIOIN	F6Q2U2_CIOIN	ENSCINP00000014316	ENSCINP00000013314	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	CNH domain-containing protein.	0.995
F6SZ37_CIOIN	F6YU56_CIOIN	ENSCINP00000014316	ENSCINP00000026122	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Uncharacterized protein.	0.954
F6SZ37_CIOIN	F7BBV8_CIOIN	ENSCINP00000014316	ENSCINP00000011601	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	CNH domain-containing protein.	0.994
F6SZ37_CIOIN	H2XX14_CIOIN	ENSCINP00000014316	ENSCINP00000034198	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Uncharacterized protein.	0.954
F6SZ37_CIOIN	LOC100180059	ENSCINP00000014316	ENSCINP00000014583	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family.	0.955