(46 nodes) Negative regulation of the PI3K/AKT network network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6PQJ9_CIOIN	PIPK domain-containing protein. (165 aa)
	LOC100182493	Growth factor receptor-bound protein 2-like isoform X1. (152 aa)
	fgf4/5/6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	fgfr	Fibroblast growth factor receptor; Receptor for basic fibroblast growth factor. (665 aa)
	LOC100179961	Recep_L_domain domain-containing protein. (200 aa)
	LOC100183420	Uncharacterized protein. (224 aa)
	LOC778964	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (880 aa)
	F6W6H7_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (279 aa)
	Egfr1	Receptor protein-tyrosine kinase. (1462 aa)
	F6WMZ2_CIOIN	PIPK domain-containing protein. (453 aa)
	F6ZM98_CIOIN	C2 NT-type domain-containing protein. (356 aa)
	F7AVR8_CIOIN	Uncharacterized protein. (175 aa)
	F7AVM0_CIOIN	Uncharacterized protein. (535 aa)
	LOC100186064	Serine/threonine-protein phosphatase. (314 aa)
	Fgf9/16/20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (297 aa)
	F6SPI7_CIOIN	Uncharacterized protein. (573 aa)
	Fgfl	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (658 aa)
	F7B6Z2_CIOIN	Phosphatidylinositol 3-kinase catalytic subunit type 3. (1058 aa)
	F6UTA2_CIOIN	Uncharacterized protein. (216 aa)
	F6UT95_CIOIN	Uncharacterized protein. (74 aa)
	F6V7V9_CIOIN	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (592 aa)
	F6PQM2_CIOIN	PIPK domain-containing protein. (152 aa)
	F6YIF4_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (478 aa)
	F6X7U3_CIOIN	LisH domain-containing protein. (1112 aa)
	F6T957_CIOIN	Uncharacterized protein. (589 aa)
	F7A9Z4_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (275 aa)
	F6S4F7_CIOIN	Non-specific serine/threonine protein kinase. (512 aa)
	F6SCJ9_CIOIN	Uncharacterized protein. (497 aa)
	Fgf8/17/18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (414 aa)
	F6U7X2_CIOIN	PIPK domain-containing protein. (482 aa)
	F7ADJ3_CIOIN	Uncharacterized protein. (337 aa)
	F6V6S0_CIOIN	Uncharacterized protein. (714 aa)
	F7BLX7_CIOIN	SH2 domain-containing protein. (245 aa)
	F7BLX1_CIOIN	Uncharacterized protein. (253 aa)
	H2XJR7_CIOIN	Uncharacterized protein. (172 aa)
	H2XK17_CIOIN	Uncharacterized protein. (337 aa)
	Q1RPY5_CIOIN	Zinc finger protein. (579 aa)
	Fgf-na1	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (473 aa)
	H2XRC5_CIOIN	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (425 aa)
	H2XSA0_CIOIN	Uncharacterized protein. (181 aa)
	fgf3/7/10/22	Fibroblast growth factor 3/7/10/22; Belongs to the heparin-binding growth factors family. (268 aa)
	LOC100183719	Uncharacterized protein. (231 aa)
	H2XY70_CIOIN	Recep_L_domain domain-containing protein. (209 aa)
	H2XZH2_CIOIN	Uncharacterized protein. (321 aa)
	H2Y0G9_CIOIN	WD_REPEATS_REGION domain-containing protein. (692 aa)
	LOC100178753	Ig-like domain-containing protein. (150 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Egfr1	F7B6Z2_CIOIN	ENSCINP00000006067	ENSCINP00000010684	Receptor protein-tyrosine kinase.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.513
Egfr1	F7BLX1_CIOIN	ENSCINP00000006067	ENSCINP00000024453	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.524
Egfr1	F7BLX7_CIOIN	ENSCINP00000006067	ENSCINP00000024452	Receptor protein-tyrosine kinase.	SH2 domain-containing protein.	0.524
Egfr1	LOC100182493	ENSCINP00000006067	ENSCINP00000001039	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2-like isoform X1.	0.745
Egfr1	LOC100183719	ENSCINP00000006067	ENSCINP00000033135	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.745
F6PQJ9_CIOIN	F6U7X2_CIOIN	ENSCINP00000013393	ENSCINP00000019443	PIPK domain-containing protein.	PIPK domain-containing protein.	0.551
F6PQJ9_CIOIN	F6WMZ2_CIOIN	ENSCINP00000013393	ENSCINP00000006755	PIPK domain-containing protein.	PIPK domain-containing protein.	0.900
F6PQJ9_CIOIN	F7BLX1_CIOIN	ENSCINP00000013393	ENSCINP00000024453	PIPK domain-containing protein.	Uncharacterized protein.	0.909
F6PQM2_CIOIN	F6U7X2_CIOIN	ENSCINP00000013390	ENSCINP00000019443	PIPK domain-containing protein.	PIPK domain-containing protein.	0.551
F6S4F7_CIOIN	F6SCJ9_CIOIN	ENSCINP00000016461	ENSCINP00000017909	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.428
F6S4F7_CIOIN	F6T957_CIOIN	ENSCINP00000016461	ENSCINP00000015461	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.617
F6S4F7_CIOIN	F6UT95_CIOIN	ENSCINP00000016461	ENSCINP00000011513	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.479
F6S4F7_CIOIN	F6UTA2_CIOIN	ENSCINP00000016461	ENSCINP00000011511	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.479
F6S4F7_CIOIN	F6V6S0_CIOIN	ENSCINP00000016461	ENSCINP00000024036	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.428
F6S4F7_CIOIN	F6V7V9_CIOIN	ENSCINP00000016461	ENSCINP00000012040	Non-specific serine/threonine protein kinase.	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit.	0.479
F6S4F7_CIOIN	F6X7U3_CIOIN	ENSCINP00000016461	ENSCINP00000015377	Non-specific serine/threonine protein kinase.	LisH domain-containing protein.	0.428
F6S4F7_CIOIN	F7B6Z2_CIOIN	ENSCINP00000016461	ENSCINP00000010684	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.774
F6S4F7_CIOIN	F7BLX1_CIOIN	ENSCINP00000016461	ENSCINP00000024453	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.652
F6S4F7_CIOIN	F7BLX7_CIOIN	ENSCINP00000016461	ENSCINP00000024452	Non-specific serine/threonine protein kinase.	SH2 domain-containing protein.	0.652
F6S4F7_CIOIN	H2XK17_CIOIN	ENSCINP00000016461	ENSCINP00000029999	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.847