(30 nodes) Nonhomologous End-Joining (NHEJ) network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100185732	DRMBL domain-containing protein. (277 aa)
	LOC100177452	Uncharacterized protein. (603 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	F7B012_CIOIN	UBIQUITIN_CONJUGAT_2 domain-containing protein. (130 aa)
	LOC100184966	Histone H2B-like; Belongs to the histone H2B family. (121 aa)
	F6RZ99_CIOIN	Zinc-hook domain-containing protein. (477 aa)
	F6RYY5_CIOIN	AAA_23 domain-containing protein. (400 aa)
	F6QHZ5_CIOIN	FHA domain-containing protein. (234 aa)
	LOC100184240	Ubiquitin-conjugating enzyme E2 35-like isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	F6WPB7_CIOIN	BRCC36_C domain-containing protein. (108 aa)
	LOC100185652	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (530 aa)
	F6UX10_CIOIN	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (655 aa)
	LOC108949301	BRCT domain-containing protein. (292 aa)
	F6TK51_CIOIN	Uncharacterized protein. (350 aa)
	F6QH43_CIOIN	RING-type domain-containing protein. (309 aa)
	F7A9P4_CIOIN	NUC194 domain-containing protein. (726 aa)
	F6RAS4_CIOIN	Uncharacterized protein. (405 aa)
	F6Q2W2_CIOIN	ANK_REP_REGION domain-containing protein. (223 aa)
	F6TYB0_CIOIN	BRCT domain-containing protein. (246 aa)
	zf(ring)-23	RING-type domain-containing protein. (319 aa)
	H2XLY1_CIOIN	Uncharacterized protein. (292 aa)
	H2XNU2_CIOIN	Uncharacterized protein. (214 aa)
	H2XQC3_CIOIN	DNA_pol_B_thumb domain-containing protein. (110 aa)
	H2Y1A0_CIOIN	Uncharacterized protein. (345 aa)
	LOC100175013	Uncharacterized protein. (379 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	H2Y3C6_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (540 aa)
	H2Y3G4_CIOIN	BRCT domain-containing protein. (335 aa)
	H2Y3M4_CIOIN	Uncharacterized protein. (185 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q2W2_CIOIN	F6QH43_CIOIN	ENSCINP00000025008	ENSCINP00000020173	ANK_REP_REGION domain-containing protein.	RING-type domain-containing protein.	0.972
F6Q2W2_CIOIN	F6QHZ5_CIOIN	ENSCINP00000025008	ENSCINP00000004918	ANK_REP_REGION domain-containing protein.	FHA domain-containing protein.	0.875
F6Q2W2_CIOIN	F6RJ65_CIOIN	ENSCINP00000025008	ENSCINP00000001490	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.494
F6Q2W2_CIOIN	F6RYY5_CIOIN	ENSCINP00000025008	ENSCINP00000003245	ANK_REP_REGION domain-containing protein.	AAA_23 domain-containing protein.	0.615
F6Q2W2_CIOIN	F6RZ99_CIOIN	ENSCINP00000025008	ENSCINP00000003235	ANK_REP_REGION domain-containing protein.	Zinc-hook domain-containing protein.	0.615
F6Q2W2_CIOIN	F6TK51_CIOIN	ENSCINP00000025008	ENSCINP00000019452	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.459
F6Q2W2_CIOIN	F6WPB7_CIOIN	ENSCINP00000025008	ENSCINP00000009483	ANK_REP_REGION domain-containing protein.	BRCC36_C domain-containing protein.	0.739
F6Q2W2_CIOIN	F7B012_CIOIN	ENSCINP00000025008	ENSCINP00000002039	ANK_REP_REGION domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.490
F6Q2W2_CIOIN	H2XLY1_CIOIN	ENSCINP00000025008	ENSCINP00000030663	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.710
F6Q2W2_CIOIN	H2XNU2_CIOIN	ENSCINP00000025008	ENSCINP00000031325	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.615
F6Q2W2_CIOIN	H2Y1A0_CIOIN	ENSCINP00000025008	ENSCINP00000035684	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.715
F6Q2W2_CIOIN	H2Y2T2_CIOIN	ENSCINP00000025008	ENSCINP00000036217	ANK_REP_REGION domain-containing protein.	FAT domain-containing protein.	0.494
F6Q2W2_CIOIN	H2Y3G4_CIOIN	ENSCINP00000025008	ENSCINP00000036449	ANK_REP_REGION domain-containing protein.	BRCT domain-containing protein.	0.459
F6Q2W2_CIOIN	LOC100184240	ENSCINP00000025008	ENSCINP00000006560	ANK_REP_REGION domain-containing protein.	Ubiquitin-conjugating enzyme E2 35-like isoform X2; Belongs to the ubiquitin-conjugating enzyme family.	0.499
F6Q2W2_CIOIN	LOC100184966	ENSCINP00000025008	ENSCINP00000002195	ANK_REP_REGION domain-containing protein.	Histone H2B-like; Belongs to the histone H2B family.	0.535
F6Q2W2_CIOIN	LOC100185652	ENSCINP00000025008	ENSCINP00000010283	ANK_REP_REGION domain-containing protein.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.887
F6Q2W2_CIOIN	LOC100185732	ENSCINP00000025008	ENSCINP00000008060	ANK_REP_REGION domain-containing protein.	DRMBL domain-containing protein.	0.459
F6Q2W2_CIOIN	LOC108949301	ENSCINP00000025008	ENSCINP00000019451	ANK_REP_REGION domain-containing protein.	BRCT domain-containing protein.	0.459
F6Q2W2_CIOIN	zf(ring)-23	ENSCINP00000025008	ENSCINP00000029036	ANK_REP_REGION domain-containing protein.	RING-type domain-containing protein.	0.433
F6QH43_CIOIN	F6Q2W2_CIOIN	ENSCINP00000020173	ENSCINP00000025008	RING-type domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.972