(63 nodes) Respiratory electron transport network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100179441	Uncharacterized protein. (61 aa)
	F7B2I2_CIOIN	dNK domain-containing protein. (271 aa)
	LOC100183394	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like. (117 aa)
	F6TH13_CIOIN	DUF4706 domain-containing protein. (150 aa)
	LOC100181220	Iron-sulfur protein NUBPL isoform X2. (310 aa)
	LOC100181337	Cytochrome c oxidase subunit 5A, mitochondrial-like. (151 aa)
	LOC100185261	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8. (192 aa)
	F6SYB9_CIOIN	DUF862 domain-containing protein. (141 aa)
	F6TYK2_CIOIN	L51_S25_CI-B8 domain-containing protein. (49 aa)
	LOC100180061	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like. (113 aa)
	LOC100176555	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like. (113 aa)
	F6U5C3_CIOIN	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (85 aa)
	LOC100178719	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6. (178 aa)
	LOC100183052	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (275 aa)
	LOC104265415	WW domain-binding protein 2-like. (234 aa)
	LOC100177491	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (222 aa)
	LOC100184221	Protein SCO1 homolog, mitochondrial-like. (291 aa)
	LOC100183392	Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (416 aa)
	F7B499_CIOIN	Methyltransf_11 domain-containing protein. (325 aa)
	LOC100175883	ETF domain-containing protein. (254 aa)
	F6ZCR7_CIOIN	Uncharacterized protein. (172 aa)
	F6RJV3_CIOIN	ETF domain-containing protein. (334 aa)
	LOC100176138	NADH-ubiquinone oxidoreductase 49 kDa subunit-like; Belongs to the complex I 49 kDa subunit family. (471 aa)
	LOC100185471	Uncharacterized protein; Belongs to the complex I 75 kDa subunit family. (727 aa)
	F6Z0W4_CIOIN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (144 aa)
	F7BQ30_CIOIN	HATPase_c domain-containing protein. (671 aa)
	F6WKB8_CIOIN	CIA30 domain-containing protein. (322 aa)
	F6TXN5_CIOIN	Uncharacterized protein. (245 aa)
	LOC100187271	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (599 aa)
	F6XNX8_CIOIN	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family. (254 aa)
	LOC100180370	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4. (190 aa)
	LOC100187136	Uncharacterized protein. (443 aa)
	LOC100176872	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial. (192 aa)
	LOC100184020	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial. (230 aa)
	LOC100175433	Transmembrane protein 126A-like. (230 aa)
	LOC100185783	Deubiquitinase DESI2 isoform X1. (174 aa)
	LOC100186511	Uncharacterized protein. (93 aa)
	NADH5	NADH dehydrogenase subunit 5. (578 aa)
	COI	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (520 aa)
	NADH4	NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (442 aa)
	NADH3	NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (113 aa)
	NADH1	NADH-ubiquinone oxidoreductase chain 1; Belongs to the complex I subunit 1 family. (302 aa)
	COIII	Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (262 aa)
	cytb	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (361 aa)
	COII	Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (229 aa)
	NADH2	NADH dehydrogenase subunit 2. (357 aa)
	H2Y1R1_CIOIN	Uncharacterized protein. (182 aa)
	LOC113474267	Uncharacterized protein. (177 aa)
	H2XZV2_CIOIN	Uncharacterized protein. (158 aa)
	LOC100181796	Cytochrome c oxidase subunit 6A, mitochondrial; Belongs to the cytochrome c oxidase subunit 6A family. (108 aa)
	H2XYL3_CIOIN	Cytochrome c domain-containing protein. (304 aa)
	LOC100176100	Uncharacterized protein. (383 aa)
	LOC100179843	Uncharacterized protein LOC100179843. (324 aa)
	LOC100181042	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (139 aa)
	LOC100187030	Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (104 aa)
	LOC100184986	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
	H2XTD8_CIOIN	ECSIT_Cterm domain-containing protein. (305 aa)
	H2XRW4_CIOIN	Uncharacterized protein. (214 aa)
	H2XNI9_CIOIN	Uncharacterized protein. (177 aa)
	H2XN49_CIOIN	Uncharacterized protein. (140 aa)
	LOC100180671	Cytochrome b-c1 complex subunit 8-like. (89 aa)
	H2XMA9_CIOIN	Uncharacterized protein; Belongs to the complex I LYR family. (188 aa)
	H2XLX1_CIOIN	Uncharacterized protein. (447 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COI	COII	ENSCINP00000036599	ENSCINP00000036591	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.	0.999
COI	COIII	ENSCINP00000036599	ENSCINP00000036594	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex.	0.999
COI	F6TH13_CIOIN	ENSCINP00000036599	ENSCINP00000028107	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	DUF4706 domain-containing protein.	0.990
COI	F6TXN5_CIOIN	ENSCINP00000036599	ENSCINP00000008003	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.975
COI	F6TYK2_CIOIN	ENSCINP00000036599	ENSCINP00000025992	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	L51_S25_CI-B8 domain-containing protein.	0.716
COI	F6U5C3_CIOIN	ENSCINP00000036599	ENSCINP00000023295	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.963
COI	F6XNX8_CIOIN	ENSCINP00000036599	ENSCINP00000005486	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.	0.783
COI	F6Z0W4_CIOIN	ENSCINP00000036599	ENSCINP00000010731	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.727
COI	F6ZCR7_CIOIN	ENSCINP00000036599	ENSCINP00000014125	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.870
COI	F7B2I2_CIOIN	ENSCINP00000036599	ENSCINP00000029303	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	dNK domain-containing protein.	0.738
COI	H2XLX1_CIOIN	ENSCINP00000036599	ENSCINP00000030653	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.957
COI	H2XMA9_CIOIN	ENSCINP00000036599	ENSCINP00000030792	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein; Belongs to the complex I LYR family.	0.730
COI	H2XN49_CIOIN	ENSCINP00000036599	ENSCINP00000031082	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.736
COI	H2XNI9_CIOIN	ENSCINP00000036599	ENSCINP00000031222	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.755
COI	H2XRW4_CIOIN	ENSCINP00000036599	ENSCINP00000032398	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.951
COI	H2XYL3_CIOIN	ENSCINP00000036599	ENSCINP00000034747	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Cytochrome c domain-containing protein.	0.999
COI	H2XZV2_CIOIN	ENSCINP00000036599	ENSCINP00000035186	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.950
COI	LOC100176100	ENSCINP00000036599	ENSCINP00000034697	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Uncharacterized protein.	0.953
COI	LOC100176138	ENSCINP00000036599	ENSCINP00000012173	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	NADH-ubiquinone oxidoreductase 49 kDa subunit-like; Belongs to the complex I 49 kDa subunit family.	0.980
COI	LOC100176555	ENSCINP00000036599	ENSCINP00000024567	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like.	0.511