(36 nodes) Pyruvate metabolism and Citric Acid (TCA) cycle network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	H2XU13_CIOIN	Citrate synthase; Belongs to the citrate synthase family. (469 aa)
	H2Y0X5_CIOIN	FAA_hydrolase domain-containing protein. (227 aa)
	LOC100180725	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (166 aa)
	F6PL95_CIOIN	Uncharacterized protein. (418 aa)
	F6PL99_CIOIN	Aconitase domain-containing protein. (347 aa)
	LOC100178529	Malate dehydrogenase, mitochondrial-like; Belongs to the LDH/MDH superfamily. (345 aa)
	F6ZF70_CIOIN	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (422 aa)
	LOC100177202	Uncharacterized protein. (1029 aa)
	F6Z761_CIOIN	Uncharacterized protein. (470 aa)
	F6WR85_CIOIN	Dihydrolipoyl dehydrogenase. (509 aa)
	LOC100175858	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (452 aa)
	LOC100186950	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like. (398 aa)
	LOC100184967	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (432 aa)
	F6SUS9_CIOIN	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (370 aa)
	LOC100181830	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (292 aa)
	F7AZV0_CIOIN	Lipoyl-binding domain-containing protein. (391 aa)
	F6RKR7_CIOIN	DAO domain-containing protein. (407 aa)
	F6ZE91_CIOIN	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (180 aa)
	LOC100184477	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (385 aa)
	F6UHA9_CIOIN	2-oxogl_dehyd_N domain-containing protein. (264 aa)
	F6V7M4_CIOIN	Transket_pyr domain-containing protein. (156 aa)
	F6UTV1_CIOIN	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (337 aa)
	LOC100186144	Fe-ADH domain-containing protein. (433 aa)
	F6YNQ3_CIOIN	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (353 aa)
	F6SI53_CIOIN	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (516 aa)
	LOC100174998	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (341 aa)
	F7BBJ9_CIOIN	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (357 aa)
	LOC100185085	Protein-serine/threonine kinase. (428 aa)
	F6YIX5_CIOIN	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (476 aa)
	F6W0L1_CIOIN	FAD-binding PCMH-type domain-containing protein. (509 aa)
	LOC100187068	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (123 aa)
	ppar	Nuclear receptor. (644 aa)
	F7BH52_CIOIN	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (508 aa)
	LOC100175853	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (109 aa)
	H2XN84_CIOIN	FAD_binding_2 domain-containing protein. (152 aa)
	LOC100176146	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (125 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PL95_CIOIN	F6PL99_CIOIN	ENSCINP00000018217	ENSCINP00000018216	Uncharacterized protein.	Aconitase domain-containing protein.	0.951
F6PL95_CIOIN	F6SI53_CIOIN	ENSCINP00000018217	ENSCINP00000008904	Uncharacterized protein.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.728
F6PL95_CIOIN	F6SUS9_CIOIN	ENSCINP00000018217	ENSCINP00000014956	Uncharacterized protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.990
F6PL95_CIOIN	F6UHA9_CIOIN	ENSCINP00000018217	ENSCINP00000012074	Uncharacterized protein.	2-oxogl_dehyd_N domain-containing protein.	0.861
F6PL95_CIOIN	F6UTV1_CIOIN	ENSCINP00000018217	ENSCINP00000011271	Uncharacterized protein.	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.	0.784
F6PL95_CIOIN	F6V7M4_CIOIN	ENSCINP00000018217	ENSCINP00000012048	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.686
F6PL95_CIOIN	F6WR85_CIOIN	ENSCINP00000018217	ENSCINP00000016324	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.554
F6PL95_CIOIN	F6YIX5_CIOIN	ENSCINP00000018217	ENSCINP00000003336	Uncharacterized protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.420
F6PL95_CIOIN	F6YNQ3_CIOIN	ENSCINP00000018217	ENSCINP00000009125	Uncharacterized protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.976
F6PL95_CIOIN	F6Z761_CIOIN	ENSCINP00000018217	ENSCINP00000016516	Uncharacterized protein.	Uncharacterized protein.	0.690
F6PL95_CIOIN	F6ZF70_CIOIN	ENSCINP00000018217	ENSCINP00000017691	Uncharacterized protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.985
F6PL95_CIOIN	F7AZV0_CIOIN	ENSCINP00000018217	ENSCINP00000014023	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.778
F6PL95_CIOIN	F7BBJ9_CIOIN	ENSCINP00000018217	ENSCINP00000006593	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.494
F6PL95_CIOIN	F7BH52_CIOIN	ENSCINP00000018217	ENSCINP00000026648	Uncharacterized protein.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.429
F6PL95_CIOIN	H2XN84_CIOIN	ENSCINP00000018217	ENSCINP00000031117	Uncharacterized protein.	FAD_binding_2 domain-containing protein.	0.728
F6PL95_CIOIN	H2XU13_CIOIN	ENSCINP00000018217	ENSCINP00000033147	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.995
F6PL95_CIOIN	LOC100175858	ENSCINP00000018217	ENSCINP00000015522	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.646
F6PL95_CIOIN	LOC100178529	ENSCINP00000018217	ENSCINP00000017905	Uncharacterized protein.	Malate dehydrogenase, mitochondrial-like; Belongs to the LDH/MDH superfamily.	0.710
F6PL95_CIOIN	LOC100181830	ENSCINP00000018217	ENSCINP00000014095	Uncharacterized protein.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.766
F6PL95_CIOIN	LOC100184477	ENSCINP00000018217	ENSCINP00000012352	Uncharacterized protein.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.500