(71 nodes) RAB GEFs exchange GTP for GDP on RABs network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	H2XWC0_CIOIN	Uncharacterized protein. (120 aa)
	LOC113474008	Trafficking protein particle complex subunit 2-like. (140 aa)
	F6VSL5_CIOIN	RIC1 domain-containing protein. (364 aa)
	F6VS42_CIOIN	Uncharacterized protein. (494 aa)
	F6SBQ3_CIOIN	UDENN domain-containing protein. (541 aa)
	LOC100177880	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa)
	F7AE11_CIOIN	RUN domain-containing protein. (223 aa)
	F6YIL9_CIOIN	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (437 aa)
	F6ZS04_CIOIN	Uncharacterized protein. (423 aa)
	F6PJ75_CIOIN	Sec2p domain-containing protein. (274 aa)
	LOC100177212	Uncharacterized protein. (227 aa)
	F6R8C3_CIOIN	Uncharacterized protein. (780 aa)
	LOC100178081	Ras-related protein Rab-6A. (209 aa)
	LOC100182193	Ras-related protein Rab-5B. (217 aa)
	F6TAL4_CIOIN	UDENN domain-containing protein. (325 aa)
	LOC100182527	MORN repeat-containing protein 3-like. (238 aa)
	LOC100185758	Ras-related protein Rab-10-like. (202 aa)
	F6VY76_CIOIN	Uncharacterized protein. (210 aa)
	LOC100186853	Trafficking protein particle complex subunit 13. (389 aa)
	LOC100176263	Lebercilin isoform X4. (727 aa)
	LOC100178332	Ras-related protein Rab-9B-like. (206 aa)
	LOC100177266	Uncharacterized protein. (211 aa)
	ci-morn40	Radial spoke protein MORN40. (300 aa)
	LOC100178266	Uncharacterized protein. (213 aa)
	F6U189_CIOIN	Uncharacterized protein. (163 aa)
	LOC100185576	Ras-related protein Rab-18. (200 aa)
	LOC100176126	Ras-related protein Rab-14. (214 aa)
	LOC100186471	MORN repeat-containing protein 5-like. (270 aa)
	LOC100183094	Ras-related protein rab7-like. (206 aa)
	F7A9X0_CIOIN	Protein kinase domain-containing protein. (772 aa)
	LOC100185231	RAB6A-GEF complex partner protein 2. (386 aa)
	F6S4F7_CIOIN	Non-specific serine/threonine protein kinase. (512 aa)
	F7B4B2_CIOIN	Uncharacterized protein. (470 aa)
	F6T120_CIOIN	TPR_REGION domain-containing protein. (357 aa)
	F6WN54_CIOIN	Uncharacterized protein. (965 aa)
	F6U9N4_CIOIN	Uncharacterized protein. (459 aa)
	LOC100183241	Ras-related protein Rab-10-like isoform X1. (207 aa)
	F6SXW5_CIOIN	Uncharacterized protein. (1463 aa)
	F6ZDX4_CIOIN	Uncharacterized protein. (460 aa)
	F6XIT4_CIOIN	Uncharacterized protein. (273 aa)
	F7BKM3_CIOIN	Uncharacterized protein. (506 aa)
	F6XND0_CIOIN	Uncharacterized protein. (233 aa)
	F6SQN7_CIOIN	CABIT domain-containing protein. (261 aa)
	F6VH27_CIOIN	Uncharacterized protein. (182 aa)
	F7AK80_CIOIN	Uncharacterized protein. (382 aa)
	H2XKA3_CIOIN	Uncharacterized protein. (312 aa)
	H2XL48_CIOIN	Uncharacterized protein. (182 aa)
	LOC100185850	Ras-related protein ORAB-1. (204 aa)
	LOC100183093	Trafficking protein particle complex subunit 6B-like. (157 aa)
	H2XMQ8_CIOIN	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (646 aa)
	H2XN10_CIOIN	Uncharacterized protein. (271 aa)
	H2XNB0_CIOIN	Uncharacterized protein. (1879 aa)
	H2XNT1_CIOIN	Uncharacterized protein. (838 aa)
	H2XPJ6_CIOIN	Uncharacterized protein. (446 aa)
	H2XQC5_CIOIN	Uncharacterized protein. (227 aa)
	H2XQD8_CIOIN	UDENN domain-containing protein. (258 aa)
	H2XQY4_CIOIN	WD_REPEATS_REGION domain-containing protein. (332 aa)
	H2XS90_CIOIN	Uncharacterized protein. (317 aa)
	LOC100181589	UDENN domain-containing protein. (575 aa)
	H2XUI1_CIOIN	Uncharacterized protein. (122 aa)
	H2XUX2_CIOIN	Uncharacterized protein. (213 aa)
	H2XXY3_CIOIN	Uncharacterized protein. (1316 aa)
	H2XYK7_CIOIN	UDENN domain-containing protein. (220 aa)
	Zf(mynd)-13	Uncharacterized protein. (174 aa)
	H2XZG3_CIOIN	Uncharacterized protein. (242 aa)
	H2Y100_CIOIN	Uncharacterized protein. (1122 aa)
	H2Y153_CIOIN	UDENN domain-containing protein. (218 aa)
	H2Y1U8_CIOIN	Uncharacterized protein. (232 aa)
	H2Y2A0_CIOIN	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (214 aa)
	H2Y2U9_CIOIN	Uncharacterized protein. (884 aa)
	H2Y397_CIOIN	Uncharacterized protein. (618 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PJ75_CIOIN	F6SQN7_CIOIN	ENSCINP00000004792	ENSCINP00000025695	Sec2p domain-containing protein.	CABIT domain-containing protein.	0.746
F6PJ75_CIOIN	F6U9N4_CIOIN	ENSCINP00000004792	ENSCINP00000019131	Sec2p domain-containing protein.	Uncharacterized protein.	0.746
F6PJ75_CIOIN	F6VH27_CIOIN	ENSCINP00000004792	ENSCINP00000028374	Sec2p domain-containing protein.	Uncharacterized protein.	0.675
F6PJ75_CIOIN	F6YIL9_CIOIN	ENSCINP00000004792	ENSCINP00000003345	Sec2p domain-containing protein.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.714
F6PJ75_CIOIN	H2XMQ8_CIOIN	ENSCINP00000004792	ENSCINP00000030941	Sec2p domain-containing protein.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.465
F6PJ75_CIOIN	H2XWC0_CIOIN	ENSCINP00000004792	ENSCINP00000033954	Sec2p domain-containing protein.	Uncharacterized protein.	0.746
F6PJ75_CIOIN	LOC100177266	ENSCINP00000004792	ENSCINP00000012676	Sec2p domain-containing protein.	Uncharacterized protein.	0.643
F6PJ75_CIOIN	LOC100183094	ENSCINP00000004792	ENSCINP00000015933	Sec2p domain-containing protein.	Ras-related protein rab7-like.	0.643
F6PJ75_CIOIN	LOC100183241	ENSCINP00000004792	ENSCINP00000019409	Sec2p domain-containing protein.	Ras-related protein Rab-10-like isoform X1.	0.778
F6PJ75_CIOIN	LOC100185758	ENSCINP00000004792	ENSCINP00000008192	Sec2p domain-containing protein.	Ras-related protein Rab-10-like.	0.778
F6R8C3_CIOIN	F7BKM3_CIOIN	ENSCINP00000006022	ENSCINP00000024722	Uncharacterized protein.	Uncharacterized protein.	0.527
F6R8C3_CIOIN	Zf(mynd)-13	ENSCINP00000006022	ENSCINP00000034762	Uncharacterized protein.	Uncharacterized protein.	0.498
F6SBQ3_CIOIN	LOC100178081	ENSCINP00000002386	ENSCINP00000006041	UDENN domain-containing protein.	Ras-related protein Rab-6A.	0.555
F6SQN7_CIOIN	F6PJ75_CIOIN	ENSCINP00000025695	ENSCINP00000004792	CABIT domain-containing protein.	Sec2p domain-containing protein.	0.746
F6SQN7_CIOIN	F6YIL9_CIOIN	ENSCINP00000025695	ENSCINP00000003345	CABIT domain-containing protein.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.753
F6SQN7_CIOIN	H2XMQ8_CIOIN	ENSCINP00000025695	ENSCINP00000030941	CABIT domain-containing protein.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.527
F6SQN7_CIOIN	H2XPJ6_CIOIN	ENSCINP00000025695	ENSCINP00000031580	CABIT domain-containing protein.	Uncharacterized protein.	0.439
F6SQN7_CIOIN	LOC100178332	ENSCINP00000025695	ENSCINP00000012228	CABIT domain-containing protein.	Ras-related protein Rab-9B-like.	0.406
F6SQN7_CIOIN	LOC100185850	ENSCINP00000025695	ENSCINP00000030419	CABIT domain-containing protein.	Ras-related protein ORAB-1.	0.603
F6SXW5_CIOIN	F6YIL9_CIOIN	ENSCINP00000019481	ENSCINP00000003345	Uncharacterized protein.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.489