(19 nodes) (2012) Development of the larval anterior neurogenic domains of Terebratalia transversa (Brachiopoda) provides insights into the diversification of larval apical organs and the spiralian nervous system. network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	foxE	foxE protein. (721 aa)
	Cdx	Homeobox domain-containing protein. (394 aa)
	Syt1	Uncharacterized protein. (328 aa)
	foxk	Uncharacterized protein. (614 aa)
	pitx	Paired superclass homeobox transcription factor isoform X1. (468 aa)
	foxL	Fork-head domain-containing protein. (387 aa)
	LOC100177479	Uncharacterized protein; Belongs to the actin family. (370 aa)
	Foxn2/3	Fork-head domain-containing protein. (748 aa)
	foxj2	Transcription factor protein isoform X1. (560 aa)
	act	Act protein isoform X1. (375 aa)
	foxf	Fork-head domain-containing protein. (575 aa)
	foxm	Fork-head domain-containing protein. (916 aa)
	Foxo	Fork-head domain-containing protein. (213 aa)
	foxa-a	Transcription factor protein isoform 1. (633 aa)
	otx2	Transcription factor protein. (425 aa)
	Bmp2/4	TGFb_propeptide domain-containing protein. (376 aa)
	Foxc	Fork-head domain-containing protein. (510 aa)
	Aristaless	Homeobox domain-containing protein. (429 aa)
	Foxp	Fork-head domain-containing protein. (745 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp2/4	Cdx	ENSCINP00000031019	ENSCINP00000015052	TGFb_propeptide domain-containing protein.	Homeobox domain-containing protein.	0.405
Bmp2/4	Foxo	ENSCINP00000031019	ENSCINP00000035316	TGFb_propeptide domain-containing protein.	Fork-head domain-containing protein.	0.503
Bmp2/4	foxf	ENSCINP00000031019	ENSCINP00000019099	TGFb_propeptide domain-containing protein.	Fork-head domain-containing protein.	0.687
Bmp2/4	otx2	ENSCINP00000031019	ENSCINP00000031453	TGFb_propeptide domain-containing protein.	Transcription factor protein.	0.601
Bmp2/4	pitx	ENSCINP00000031019	ENSCINP00000010867	TGFb_propeptide domain-containing protein.	Paired superclass homeobox transcription factor isoform X1.	0.496
Cdx	Bmp2/4	ENSCINP00000015052	ENSCINP00000031019	Homeobox domain-containing protein.	TGFb_propeptide domain-containing protein.	0.405
Cdx	otx2	ENSCINP00000015052	ENSCINP00000031453	Homeobox domain-containing protein.	Transcription factor protein.	0.477
Foxc	otx2	ENSCINP00000030676	ENSCINP00000031453	Fork-head domain-containing protein.	Transcription factor protein.	0.505
Foxn2/3	Foxo	ENSCINP00000002081	ENSCINP00000035316	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.455
Foxn2/3	foxE	ENSCINP00000002081	ENSCINP00000015355	Fork-head domain-containing protein.	foxE protein.	0.449
Foxn2/3	foxk	ENSCINP00000002081	ENSCINP00000012768	Fork-head domain-containing protein.	Uncharacterized protein.	0.573
Foxo	Bmp2/4	ENSCINP00000035316	ENSCINP00000031019	Fork-head domain-containing protein.	TGFb_propeptide domain-containing protein.	0.503
Foxo	Foxn2/3	ENSCINP00000035316	ENSCINP00000002081	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.455
Foxo	foxL	ENSCINP00000035316	ENSCINP00000009675	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.478
Foxo	foxj2	ENSCINP00000035316	ENSCINP00000002040	Fork-head domain-containing protein.	Transcription factor protein isoform X1.	0.419
foxE	Foxn2/3	ENSCINP00000015355	ENSCINP00000002081	foxE protein.	Fork-head domain-containing protein.	0.449
foxE	pitx	ENSCINP00000015355	ENSCINP00000010867	foxE protein.	Paired superclass homeobox transcription factor isoform X1.	0.423
foxL	Foxo	ENSCINP00000009675	ENSCINP00000035316	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.478
foxL	foxj2	ENSCINP00000009675	ENSCINP00000002040	Fork-head domain-containing protein.	Transcription factor protein isoform X1.	0.498
foxa-a	otx2	ENSCINP00000034127	ENSCINP00000031453	Transcription factor protein isoform 1.	Transcription factor protein.	0.659