(21 nodes) (2022) Double life: How GRK2 and beta-arrestin signaling participate in diseases. network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC100184552	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	LOC100186781	Calmodulin-like protein 4. (154 aa)
	H2XZQ9_CIOIN	PH domain-containing protein. (276 aa)
	LOC100184986	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (110 aa)
	H2XP64_CIOIN	Uncharacterized protein. (157 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	Ciarr	Arrestin_C domain-containing protein. (253 aa)
	nox4	FAD-binding FR-type domain-containing protein. (811 aa)
	F6PQ89_CIOIN	Uncharacterized protein. (150 aa)
	Ikappab	ANK_REP_REGION domain-containing protein. (371 aa)
	F6U5C3_CIOIN	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (85 aa)
	LOC100185723	Calmodulin-2/4-like. (160 aa)
	LOC100178859	Calmodulin-2/4-like. (158 aa)
	Cam	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	LOC494376	Calmodulin-like. (170 aa)
	F6XYE9_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (319 aa)
	LOC100181538	Uncharacterized protein. (157 aa)
	LOC100177479	Uncharacterized protein; Belongs to the actin family. (370 aa)
	F6YRG2_CIOIN	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	act	Act protein isoform X1. (375 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cam	LOC100177479	ENSCINP00000017572	ENSCINP00000006055	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein; Belongs to the actin family.	0.542
Cam	act	ENSCINP00000017572	ENSCINP00000001538	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Act protein isoform X1.	0.573
F6PQ89_CIOIN	LOC100177479	ENSCINP00000025381	ENSCINP00000006055	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.483
F6PQ89_CIOIN	act	ENSCINP00000025381	ENSCINP00000001538	Uncharacterized protein.	Act protein isoform X1.	0.514
F6U5C3_CIOIN	F6XYE9_CIOIN	ENSCINP00000023295	ENSCINP00000015083	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.651
F6U5C3_CIOIN	LOC100177479	ENSCINP00000023295	ENSCINP00000006055	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Uncharacterized protein; Belongs to the actin family.	0.434
F6U5C3_CIOIN	act	ENSCINP00000023295	ENSCINP00000001538	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Act protein isoform X1.	0.434
F6XYE9_CIOIN	F6U5C3_CIOIN	ENSCINP00000015083	ENSCINP00000023295	Uncharacterized protein; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.651
F6XYE9_CIOIN	LOC100177479	ENSCINP00000015083	ENSCINP00000006055	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the actin family.	0.499
F6XYE9_CIOIN	LOC100184986	ENSCINP00000015083	ENSCINP00000033125	Uncharacterized protein; Belongs to the peptidase C14A family.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.746
F6XYE9_CIOIN	act	ENSCINP00000015083	ENSCINP00000001538	Uncharacterized protein; Belongs to the peptidase C14A family.	Act protein isoform X1.	0.508
F6YRG2_CIOIN	LOC100177697	ENSCINP00000002792	ENSCINP00000002782	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.494
F6YRG2_CIOIN	LOC100178517	ENSCINP00000002792	ENSCINP00000030917	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.491
F6YRG2_CIOIN	LOC100181538	ENSCINP00000002792	ENSCINP00000012845	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.635
H2XP64_CIOIN	LOC100177479	ENSCINP00000031447	ENSCINP00000006055	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.483
H2XP64_CIOIN	act	ENSCINP00000031447	ENSCINP00000001538	Uncharacterized protein.	Act protein isoform X1.	0.514
LOC100177479	Cam	ENSCINP00000006055	ENSCINP00000017572	Uncharacterized protein; Belongs to the actin family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.542
LOC100177479	F6PQ89_CIOIN	ENSCINP00000006055	ENSCINP00000025381	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.483
LOC100177479	F6U5C3_CIOIN	ENSCINP00000006055	ENSCINP00000023295	Uncharacterized protein; Belongs to the actin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.434
LOC100177479	F6XYE9_CIOIN	ENSCINP00000006055	ENSCINP00000015083	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.499