(21 nodes) (2022) Mechanisms of Sperm-Egg Interactions: What Ascidian Fertilization Research Has Taught Us. network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100185723	Calmodulin-2/4-like. (160 aa)
	LOC100184552	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	act	Act protein isoform X1. (375 aa)
	LOC100177479	Uncharacterized protein; Belongs to the actin family. (370 aa)
	hsp70	Uncharacterized protein; Belongs to the heat shock protein 70 family. (627 aa)
	LOC100181538	Uncharacterized protein. (157 aa)
	LOC494376	Calmodulin-like. (170 aa)
	calx	Calaxin. (203 aa)
	Cam	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	LOC100178859	Calmodulin-2/4-like. (158 aa)
	LOC100178009	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa)
	Fibrn	Fibrinogen C-terminal domain-containing protein. (476 aa)
	F6PQ89_CIOIN	Uncharacterized protein. (150 aa)
	LOC100181838	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (260 aa)
	LOC100185684	CiUrabin; Belongs to the CRISP family. (256 aa)
	H2XP64_CIOIN	Uncharacterized protein. (157 aa)
	H2XST4_CIOIN	Uncharacterized protein. (140 aa)
	s-themis-a	Uncharacterized protein. (1981 aa)
	H2XZV3_CIOIN	Peptidase S1 domain-containing protein. (140 aa)
	LOC100186781	Calmodulin-like protein 4. (154 aa)
	H2Y0U6_CIOIN	Uncharacterized protein. (298 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cam	LOC100177479	ENSCINP00000017572	ENSCINP00000006055	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein; Belongs to the actin family.	0.542
Cam	act	ENSCINP00000017572	ENSCINP00000001538	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Act protein isoform X1.	0.573
Cam	calx	ENSCINP00000017572	ENSCINP00000015983	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Calaxin.	0.536
F6PQ89_CIOIN	LOC100177479	ENSCINP00000025381	ENSCINP00000006055	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.483
F6PQ89_CIOIN	act	ENSCINP00000025381	ENSCINP00000001538	Uncharacterized protein.	Act protein isoform X1.	0.514
Fibrn	s-themis-a	ENSCINP00000025173	ENSCINP00000034979	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.480
H2XP64_CIOIN	LOC100177479	ENSCINP00000031447	ENSCINP00000006055	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.483
H2XP64_CIOIN	act	ENSCINP00000031447	ENSCINP00000001538	Uncharacterized protein.	Act protein isoform X1.	0.514
H2XST4_CIOIN	LOC100177479	ENSCINP00000032718	ENSCINP00000006055	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.433
H2XST4_CIOIN	LOC100185684	ENSCINP00000032718	ENSCINP00000031233	Uncharacterized protein.	CiUrabin; Belongs to the CRISP family.	0.400
H2XST4_CIOIN	act	ENSCINP00000032718	ENSCINP00000001538	Uncharacterized protein.	Act protein isoform X1.	0.434
H2XZV3_CIOIN	H2Y0U6_CIOIN	ENSCINP00000035187	ENSCINP00000035530	Peptidase S1 domain-containing protein.	Uncharacterized protein.	0.478
H2Y0U6_CIOIN	H2XZV3_CIOIN	ENSCINP00000035530	ENSCINP00000035187	Uncharacterized protein.	Peptidase S1 domain-containing protein.	0.478
H2Y0U6_CIOIN	LOC100178009	ENSCINP00000035530	ENSCINP00000023997	Uncharacterized protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.478
H2Y0U6_CIOIN	LOC100181838	ENSCINP00000035530	ENSCINP00000029043	Uncharacterized protein.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.478
LOC100177479	Cam	ENSCINP00000006055	ENSCINP00000017572	Uncharacterized protein; Belongs to the actin family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.542
LOC100177479	F6PQ89_CIOIN	ENSCINP00000006055	ENSCINP00000025381	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.483
LOC100177479	H2XP64_CIOIN	ENSCINP00000006055	ENSCINP00000031447	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.483
LOC100177479	H2XST4_CIOIN	ENSCINP00000006055	ENSCINP00000032718	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.433
LOC100177479	LOC100178859	ENSCINP00000006055	ENSCINP00000021258	Uncharacterized protein; Belongs to the actin family.	Calmodulin-2/4-like.	0.483