(22 nodes) (2023) NMDA Receptor and Its Emerging Role in Cancer. network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf3/7/10/22	Fibroblast growth factor 3/7/10/22; Belongs to the heparin-binding growth factors family. (268 aa)
	LOC100186781	Calmodulin-like protein 4. (154 aa)
	Cibeta-catenin	Uncharacterized protein. (497 aa)
	LOC100181289	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	LOC100181538	Uncharacterized protein. (157 aa)
	Fgf9/16/20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (297 aa)
	Ptp	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (987 aa)
	Fgf11/12/13/14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
	LOC100184552	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	fgf4/5/6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	Fgf8/17/18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (414 aa)
	F6XHC0_CIOIN	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (443 aa)
	LOC100178859	Calmodulin-2/4-like. (158 aa)
	LOC100185723	Calmodulin-2/4-like. (160 aa)
	cam-k	Calmodulin-dependent protein kinase homologue isoform X1; Belongs to the protein kinase superfamily. (324 aa)
	F6PQ89_CIOIN	Uncharacterized protein. (150 aa)
	H2XP64_CIOIN	Uncharacterized protein. (157 aa)
	LOC100185305	Cofilin; Belongs to the actin-binding proteins ADF family. (166 aa)
	F6S7U7_CIOIN	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (505 aa)
	LOC494376	Calmodulin-like. (170 aa)
	Cam	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	vglut	MFS domain-containing protein. (663 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cam	Fgf11/12/13/14	ENSCINP00000017572	ENSCINP00000008466	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.440
Cam	cam-k	ENSCINP00000017572	ENSCINP00000023118	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Calmodulin-dependent protein kinase homologue isoform X1; Belongs to the protein kinase superfamily.	0.693
Cibeta-catenin	Fgf11/12/13/14	ENSCINP00000014417	ENSCINP00000008466	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.490
Cibeta-catenin	Fgf8/17/18	ENSCINP00000014417	ENSCINP00000018902	Uncharacterized protein.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.520
Cibeta-catenin	Fgf9/16/20	ENSCINP00000014417	ENSCINP00000009154	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.576
Cibeta-catenin	fgf3/7/10/22	ENSCINP00000014417	ENSCINP00000032792	Uncharacterized protein.	Fibroblast growth factor 3/7/10/22; Belongs to the heparin-binding growth factors family.	0.486
Cibeta-catenin	fgf4/5/6	ENSCINP00000014417	ENSCINP00000001146	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.526
F6PQ89_CIOIN	cam-k	ENSCINP00000025381	ENSCINP00000023118	Uncharacterized protein.	Calmodulin-dependent protein kinase homologue isoform X1; Belongs to the protein kinase superfamily.	0.650
F6S7U7_CIOIN	F6XHC0_CIOIN	ENSCINP00000014974	ENSCINP00000019611	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.907
F6XHC0_CIOIN	F6S7U7_CIOIN	ENSCINP00000019611	ENSCINP00000014974	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.907
Fgf11/12/13/14	Cam	ENSCINP00000008466	ENSCINP00000017572	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.440
Fgf11/12/13/14	Cibeta-catenin	ENSCINP00000008466	ENSCINP00000014417	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.490
Fgf11/12/13/14	Fgf8/17/18	ENSCINP00000008466	ENSCINP00000018902	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.673
Fgf11/12/13/14	LOC100184552	ENSCINP00000008466	ENSCINP00000001155	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the calmodulin family.	0.438
Fgf11/12/13/14	LOC494376	ENSCINP00000008466	ENSCINP00000015262	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Calmodulin-like.	0.438
Fgf8/17/18	Cibeta-catenin	ENSCINP00000018902	ENSCINP00000014417	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.520
Fgf8/17/18	Fgf11/12/13/14	ENSCINP00000018902	ENSCINP00000008466	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.673
Fgf8/17/18	Fgf9/16/20	ENSCINP00000018902	ENSCINP00000009154	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.908
Fgf8/17/18	fgf3/7/10/22	ENSCINP00000018902	ENSCINP00000032792	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 3/7/10/22; Belongs to the heparin-binding growth factors family.	0.718
Fgf8/17/18	fgf4/5/6	ENSCINP00000018902	ENSCINP00000001146	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.811