(17 nodes) Pentose phosphate pathway network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	LOC100185905	Uncharacterized protein. (248 aa)
	F6ZDC7_CIOIN	Uncharacterized protein; Belongs to the phosphohexose mutase family. (560 aa)
	F6R5L0_CIOIN	Pribosyltran_N domain-containing protein. (342 aa)
	LOC100176649	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (329 aa)
	F7AX62_CIOIN	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (482 aa)
	F6PZE7_CIOIN	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (758 aa)
	F7A4X2_CIOIN	Uncharacterized protein. (188 aa)
	F6ZG04_CIOIN	PfkB domain-containing protein. (252 aa)
	F7ANQ7_CIOIN	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (159 aa)
	F7A429_CIOIN	Transket_pyr domain-containing protein. (631 aa)
	LOC100183164	Uncharacterized protein. (474 aa)
	LOC100178673	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	LOC100176285	Uncharacterized protein. (318 aa)
	F7AZD3_CIOIN	Glucose-6-phosphate isomerase; Belongs to the GPI family. (232 aa)
	LOC100184729	Regucalcin-like. (300 aa)
	LOC100185650	Phosphoglucomutase-2. (611 aa)
	H2XQE7_CIOIN	NAD_binding_2 domain-containing protein. (176 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PZE7_CIOIN	F6R5L0_CIOIN	ENSCINP00000009557	ENSCINP00000004834	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Pribosyltran_N domain-containing protein.	0.429
F6PZE7_CIOIN	F6ZDC7_CIOIN	ENSCINP00000009557	ENSCINP00000002112	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Uncharacterized protein; Belongs to the phosphohexose mutase family.	0.788
F6PZE7_CIOIN	F6ZG04_CIOIN	ENSCINP00000009557	ENSCINP00000012547	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	PfkB domain-containing protein.	0.549
F6PZE7_CIOIN	F7A429_CIOIN	ENSCINP00000009557	ENSCINP00000015532	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Transket_pyr domain-containing protein.	0.991
F6PZE7_CIOIN	F7A4X2_CIOIN	ENSCINP00000009557	ENSCINP00000010432	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Uncharacterized protein.	0.481
F6PZE7_CIOIN	F7ANQ7_CIOIN	ENSCINP00000009557	ENSCINP00000015293	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.	0.709
F6PZE7_CIOIN	F7AX62_CIOIN	ENSCINP00000009557	ENSCINP00000007539	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.642
F6PZE7_CIOIN	F7AZD3_CIOIN	ENSCINP00000009557	ENSCINP00000019213	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.999
F6PZE7_CIOIN	H2XQE7_CIOIN	ENSCINP00000009557	ENSCINP00000031881	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	NAD_binding_2 domain-containing protein.	0.583
F6PZE7_CIOIN	LOC100176285	ENSCINP00000009557	ENSCINP00000017567	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Uncharacterized protein.	0.538
F6PZE7_CIOIN	LOC100176649	ENSCINP00000009557	ENSCINP00000005728	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.990
F6PZE7_CIOIN	LOC100178673	ENSCINP00000009557	ENSCINP00000016703	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.984
F6PZE7_CIOIN	LOC100185650	ENSCINP00000009557	ENSCINP00000026075	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Phosphoglucomutase-2.	0.826
F6PZE7_CIOIN	LOC100185905	ENSCINP00000009557	ENSCINP00000001226	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	Uncharacterized protein.	0.642
F6R5L0_CIOIN	F6PZE7_CIOIN	ENSCINP00000004834	ENSCINP00000009557	Pribosyltran_N domain-containing protein.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.429
F6R5L0_CIOIN	F6ZDC7_CIOIN	ENSCINP00000004834	ENSCINP00000002112	Pribosyltran_N domain-containing protein.	Uncharacterized protein; Belongs to the phosphohexose mutase family.	0.913
F6R5L0_CIOIN	F6ZG04_CIOIN	ENSCINP00000004834	ENSCINP00000012547	Pribosyltran_N domain-containing protein.	PfkB domain-containing protein.	0.952
F6R5L0_CIOIN	F7A429_CIOIN	ENSCINP00000004834	ENSCINP00000015532	Pribosyltran_N domain-containing protein.	Transket_pyr domain-containing protein.	0.958
F6R5L0_CIOIN	F7ANQ7_CIOIN	ENSCINP00000004834	ENSCINP00000015293	Pribosyltran_N domain-containing protein.	6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.	0.533
F6R5L0_CIOIN	F7AZD3_CIOIN	ENSCINP00000004834	ENSCINP00000019213	Pribosyltran_N domain-containing protein.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.505