(25 nodes) Glyoxylate and dicarboxylate metabolism network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6Q7P2_CIOIN	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily. (312 aa)
	F6VZQ1_CIOIN	FMN hydroxy acid dehydrogenase domain-containing protein. (354 aa)
	LOC100177845	acetyl-CoA acetyltransferase, mitochondrial-like; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	F6ZN15_CIOIN	METMALONYL_COA_MUTASE domain-containing protein. (289 aa)
	F6VUM2_CIOIN	Glutamine synthetase. (334 aa)
	LOC100176441	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (999 aa)
	LOC100176513	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (489 aa)
	F6SZD3_CIOIN	FMN hydroxy acid dehydrogenase domain-containing protein. (376 aa)
	F6THC9_CIOIN	Uncharacterized protein. (537 aa)
	F6WR85_CIOIN	Dihydrolipoyl dehydrogenase. (509 aa)
	LOC100183164	Uncharacterized protein. (474 aa)
	LOC100177936	Uncharacterized protein. (707 aa)
	LOC100187164	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (478 aa)
	LOC100178529	Malate dehydrogenase, mitochondrial-like; Belongs to the LDH/MDH superfamily. (345 aa)
	F7B0S6_CIOIN	Acetyl-coenzyme A synthetase. (667 aa)
	F6PL95_CIOIN	Uncharacterized protein. (418 aa)
	LOC100186938	Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (892 aa)
	LOC100178763	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
	H2XQG7_CIOIN	VOC domain-containing protein. (177 aa)
	H2XU13_CIOIN	Citrate synthase; Belongs to the citrate synthase family. (469 aa)
	LOC100184495	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
	H2XYN5_CIOIN	Acetyl-coenzyme A synthetase. (633 aa)
	LOC100181036	4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Belongs to the DapA family. (321 aa)
	H2Y3K9_CIOIN	Malate dehydrogenase. (334 aa)
	H2Y3Q6_CIOIN	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (371 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PL95_CIOIN	F6WR85_CIOIN	ENSCINP00000018217	ENSCINP00000016324	Uncharacterized protein.	Dihydrolipoyl dehydrogenase.	0.554
F6PL95_CIOIN	F7B0S6_CIOIN	ENSCINP00000018217	ENSCINP00000017977	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.435
F6PL95_CIOIN	H2XU13_CIOIN	ENSCINP00000018217	ENSCINP00000033147	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.995
F6PL95_CIOIN	H2XYN5_CIOIN	ENSCINP00000018217	ENSCINP00000034769	Uncharacterized protein.	Acetyl-coenzyme A synthetase.	0.435
F6PL95_CIOIN	H2Y3K9_CIOIN	ENSCINP00000018217	ENSCINP00000036494	Uncharacterized protein.	Malate dehydrogenase.	0.495
F6PL95_CIOIN	LOC100176441	ENSCINP00000018217	ENSCINP00000012269	Uncharacterized protein.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.492
F6PL95_CIOIN	LOC100178529	ENSCINP00000018217	ENSCINP00000017905	Uncharacterized protein.	Malate dehydrogenase, mitochondrial-like; Belongs to the LDH/MDH superfamily.	0.710
F6PL95_CIOIN	LOC100186938	ENSCINP00000018217	ENSCINP00000019416	Uncharacterized protein.	Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family.	0.915
F6Q7P2_CIOIN	F6SZD3_CIOIN	ENSCINP00000001017	ENSCINP00000014303	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily.	FMN hydroxy acid dehydrogenase domain-containing protein.	0.926
F6Q7P2_CIOIN	F6VZQ1_CIOIN	ENSCINP00000001017	ENSCINP00000003109	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily.	FMN hydroxy acid dehydrogenase domain-containing protein.	0.926
F6Q7P2_CIOIN	LOC100176513	ENSCINP00000001017	ENSCINP00000013673	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.495
F6Q7P2_CIOIN	LOC100178763	ENSCINP00000001017	ENSCINP00000025772	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily.	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.922
F6Q7P2_CIOIN	LOC100187164	ENSCINP00000001017	ENSCINP00000016753	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.495
F6SZD3_CIOIN	F6Q7P2_CIOIN	ENSCINP00000014303	ENSCINP00000001017	FMN hydroxy acid dehydrogenase domain-containing protein.	Uncharacterized protein; Belongs to the HAD-like hydrolase superfamily.	0.926
F6SZD3_CIOIN	F6VZQ1_CIOIN	ENSCINP00000014303	ENSCINP00000003109	FMN hydroxy acid dehydrogenase domain-containing protein.	FMN hydroxy acid dehydrogenase domain-containing protein.	0.906
F6SZD3_CIOIN	H2XQG7_CIOIN	ENSCINP00000014303	ENSCINP00000031901	FMN hydroxy acid dehydrogenase domain-containing protein.	VOC domain-containing protein.	0.552
F6SZD3_CIOIN	H2Y3Q6_CIOIN	ENSCINP00000014303	ENSCINP00000036541	FMN hydroxy acid dehydrogenase domain-containing protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.434
F6SZD3_CIOIN	LOC100178763	ENSCINP00000014303	ENSCINP00000025772	FMN hydroxy acid dehydrogenase domain-containing protein.	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.935
F6SZD3_CIOIN	LOC100181036	ENSCINP00000014303	ENSCINP00000036436	FMN hydroxy acid dehydrogenase domain-containing protein.	4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Belongs to the DapA family.	0.903
F6THC9_CIOIN	F6VUM2_CIOIN	ENSCINP00000016122	ENSCINP00000012035	Uncharacterized protein.	Glutamine synthetase.	0.548