(19 nodes) Butanoate metabolism network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	F6U1L2_CIOIN	Uncharacterized protein. (413 aa)
	LOC100186995	enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
	LOC100183445	3-hydroxybutyrate dehydrogenase type 2-like. (248 aa)
	gad	Uncharacterized protein. (531 aa)
	F6SUM0_CIOIN	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (501 aa)
	F7AAH8_CIOIN	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (502 aa)
	LOC100177845	acetyl-CoA acetyltransferase, mitochondrial-like; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	LOC100180564	Peroxisomal bifunctional enzyme-like isoform X1. (486 aa)
	LOC100182913	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa)
	LOC100187496	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like. (309 aa)
	LOC100181980	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (725 aa)
	F6RKR7_CIOIN	DAO domain-containing protein. (407 aa)
	LOC100175295	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (501 aa)
	F6RYU3_CIOIN	Uncharacterized protein. (352 aa)
	F6WXA3_CIOIN	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (473 aa)
	LOC100180018	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
	F6W0C3_CIOIN	Uncharacterized protein. (683 aa)
	LOC100180566	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (505 aa)
	H2XSN3_CIOIN	Pyruvate carboxyltransferase domain-containing protein. (323 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6RKR7_CIOIN	F6SUM0_CIOIN	ENSCINP00000013150	ENSCINP00000004184	DAO domain-containing protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.437
F6RKR7_CIOIN	F7AAH8_CIOIN	ENSCINP00000013150	ENSCINP00000004225	DAO domain-containing protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.441
F6RKR7_CIOIN	gad	ENSCINP00000013150	ENSCINP00000004013	DAO domain-containing protein.	Uncharacterized protein.	0.808
F6RYU3_CIOIN	F6W0C3_CIOIN	ENSCINP00000015221	ENSCINP00000022275	Uncharacterized protein.	Uncharacterized protein.	0.908
F6RYU3_CIOIN	H2XSN3_CIOIN	ENSCINP00000015221	ENSCINP00000032667	Uncharacterized protein.	Pyruvate carboxyltransferase domain-containing protein.	0.929
F6RYU3_CIOIN	LOC100180566	ENSCINP00000015221	ENSCINP00000024254	Uncharacterized protein.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.936
F6RYU3_CIOIN	LOC100183445	ENSCINP00000015221	ENSCINP00000003163	Uncharacterized protein.	3-hydroxybutyrate dehydrogenase type 2-like.	0.929
F6SUM0_CIOIN	F6RKR7_CIOIN	ENSCINP00000004184	ENSCINP00000013150	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	DAO domain-containing protein.	0.437
F6SUM0_CIOIN	F6U1L2_CIOIN	ENSCINP00000004184	ENSCINP00000001630	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.807
F6SUM0_CIOIN	F6WXA3_CIOIN	ENSCINP00000004184	ENSCINP00000019067	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.959
F6SUM0_CIOIN	F7AAH8_CIOIN	ENSCINP00000004184	ENSCINP00000004225	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.901
F6SUM0_CIOIN	LOC100180018	ENSCINP00000004184	ENSCINP00000019085	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.959
F6SUM0_CIOIN	LOC100180564	ENSCINP00000004184	ENSCINP00000006081	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Peroxisomal bifunctional enzyme-like isoform X1.	0.916
F6SUM0_CIOIN	LOC100182913	ENSCINP00000004184	ENSCINP00000006089	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	0.916
F6SUM0_CIOIN	LOC100187496	ENSCINP00000004184	ENSCINP00000007745	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like.	0.909
F6SUM0_CIOIN	gad	ENSCINP00000004184	ENSCINP00000004013	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.943
F6U1L2_CIOIN	F6SUM0_CIOIN	ENSCINP00000001630	ENSCINP00000004184	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.807
F6U1L2_CIOIN	F6W0C3_CIOIN	ENSCINP00000001630	ENSCINP00000022275	Uncharacterized protein.	Uncharacterized protein.	0.435
F6U1L2_CIOIN	F7AAH8_CIOIN	ENSCINP00000001630	ENSCINP00000004225	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.807
F6U1L2_CIOIN	LOC100177845	ENSCINP00000001630	ENSCINP00000004488	Uncharacterized protein.	acetyl-CoA acetyltransferase, mitochondrial-like; Belongs to the thiolase-like superfamily. Thiolase family.	0.962