(14 nodes) One carbon pool by folate network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100179457	methionyl-tRNA formyltransferase, mitochondrial. (336 aa)
	F6X034_CIOIN	Uncharacterized protein. (290 aa)
	LOC100185664	C-1-tetrahydrofolate synthase, cytoplasmic-like. (934 aa)
	LOC100178564	MGS domain-containing protein. (594 aa)
	F6XVH4_CIOIN	Thymidylat_synt domain-containing protein. (158 aa)
	LOC100180174	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (650 aa)
	LOC100176513	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (489 aa)
	F7A2X8_CIOIN	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (983 aa)
	LOC100184767	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (921 aa)
	LOC100187164	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (478 aa)
	LOC100184708	Uncharacterized protein. (522 aa)
	LOC100182410	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family. (194 aa)
	LOC100179361	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
	H2Y3Q6_CIOIN	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (371 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6X034_CIOIN	F6XVH4_CIOIN	ENSCINP00000005743	ENSCINP00000010782	Uncharacterized protein.	Thymidylat_synt domain-containing protein.	0.980
F6X034_CIOIN	F7A2X8_CIOIN	ENSCINP00000005743	ENSCINP00000015809	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
F6X034_CIOIN	H2Y3Q6_CIOIN	ENSCINP00000005743	ENSCINP00000036541	Uncharacterized protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.994
F6X034_CIOIN	LOC100176513	ENSCINP00000005743	ENSCINP00000013673	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.994
F6X034_CIOIN	LOC100178564	ENSCINP00000005743	ENSCINP00000008382	Uncharacterized protein.	MGS domain-containing protein.	0.988
F6X034_CIOIN	LOC100179361	ENSCINP00000005743	ENSCINP00000035744	Uncharacterized protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.587
F6X034_CIOIN	LOC100179457	ENSCINP00000005743	ENSCINP00000001377	Uncharacterized protein.	methionyl-tRNA formyltransferase, mitochondrial.	0.991
F6X034_CIOIN	LOC100180174	ENSCINP00000005743	ENSCINP00000013160	Uncharacterized protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.991
F6X034_CIOIN	LOC100182410	ENSCINP00000005743	ENSCINP00000031349	Uncharacterized protein.	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family.	0.578
F6X034_CIOIN	LOC100184708	ENSCINP00000005743	ENSCINP00000025584	Uncharacterized protein.	Uncharacterized protein.	0.991
F6X034_CIOIN	LOC100184767	ENSCINP00000005743	ENSCINP00000016529	Uncharacterized protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.940
F6X034_CIOIN	LOC100185664	ENSCINP00000005743	ENSCINP00000006018	Uncharacterized protein.	C-1-tetrahydrofolate synthase, cytoplasmic-like.	0.993
F6X034_CIOIN	LOC100187164	ENSCINP00000005743	ENSCINP00000016753	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.994
F6XVH4_CIOIN	F6X034_CIOIN	ENSCINP00000010782	ENSCINP00000005743	Thymidylat_synt domain-containing protein.	Uncharacterized protein.	0.980
F6XVH4_CIOIN	F7A2X8_CIOIN	ENSCINP00000010782	ENSCINP00000015809	Thymidylat_synt domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.687
F6XVH4_CIOIN	H2Y3Q6_CIOIN	ENSCINP00000010782	ENSCINP00000036541	Thymidylat_synt domain-containing protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.946
F6XVH4_CIOIN	LOC100176513	ENSCINP00000010782	ENSCINP00000013673	Thymidylat_synt domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.964
F6XVH4_CIOIN	LOC100178564	ENSCINP00000010782	ENSCINP00000008382	Thymidylat_synt domain-containing protein.	MGS domain-containing protein.	0.500
F6XVH4_CIOIN	LOC100179457	ENSCINP00000010782	ENSCINP00000001377	Thymidylat_synt domain-containing protein.	methionyl-tRNA formyltransferase, mitochondrial.	0.675
F6XVH4_CIOIN	LOC100180174	ENSCINP00000010782	ENSCINP00000013160	Thymidylat_synt domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.946