(14 nodes) Terpenoid backbone biosynthesis network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100175803	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (344 aa)
	F6SSS9_CIOIN	Nudix hydrolase domain-containing protein. (238 aa)
	LOC100177845	acetyl-CoA acetyltransferase, mitochondrial-like; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	LOC113474070	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (398 aa)
	F6Z0U1_CIOIN	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (380 aa)
	LOC100176674	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (278 aa)
	LOC100175295	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (501 aa)
	F6QHP8_CIOIN	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (349 aa)
	F6QM57_CIOIN	Prenylcys_lyase domain-containing protein. (466 aa)
	F6RX41_CIOIN	Uncharacterized protein. (148 aa)
	F6Q301_CIOIN	Uncharacterized protein. (237 aa)
	LOC100184780	CAAX prenyl protease 2-like. (282 aa)
	H2XW59_CIOIN	Uncharacterized protein. (197 aa)
	H2Y2K4_CIOIN	3-hydroxy-3-methylglutaryl coenzyme A reductase. (807 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q301_CIOIN	F6QHP8_CIOIN	ENSCINP00000025006	ENSCINP00000016900	Uncharacterized protein.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.970
F6Q301_CIOIN	F6SSS9_CIOIN	ENSCINP00000025006	ENSCINP00000004433	Uncharacterized protein.	Nudix hydrolase domain-containing protein.	0.896
F6Q301_CIOIN	F6Z0U1_CIOIN	ENSCINP00000025006	ENSCINP00000010736	Uncharacterized protein.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.660
F6Q301_CIOIN	H2Y2K4_CIOIN	ENSCINP00000025006	ENSCINP00000036139	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.678
F6Q301_CIOIN	LOC100175295	ENSCINP00000025006	ENSCINP00000014459	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.618
F6Q301_CIOIN	LOC100175803	ENSCINP00000025006	ENSCINP00000002476	Uncharacterized protein.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.970
F6Q301_CIOIN	LOC100184780	ENSCINP00000025006	ENSCINP00000029889	Uncharacterized protein.	CAAX prenyl protease 2-like.	0.476
F6Q301_CIOIN	LOC113474070	ENSCINP00000025006	ENSCINP00000005299	Uncharacterized protein.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.970
F6QHP8_CIOIN	F6Q301_CIOIN	ENSCINP00000016900	ENSCINP00000025006	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.970
F6QHP8_CIOIN	F6SSS9_CIOIN	ENSCINP00000016900	ENSCINP00000004433	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Nudix hydrolase domain-containing protein.	0.994
F6QHP8_CIOIN	F6Z0U1_CIOIN	ENSCINP00000016900	ENSCINP00000010736	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.990
F6QHP8_CIOIN	H2XW59_CIOIN	ENSCINP00000016900	ENSCINP00000033893	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.657
F6QHP8_CIOIN	H2Y2K4_CIOIN	ENSCINP00000016900	ENSCINP00000036139	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.736
F6QHP8_CIOIN	LOC100175295	ENSCINP00000016900	ENSCINP00000014459	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.973
F6QHP8_CIOIN	LOC100175803	ENSCINP00000016900	ENSCINP00000002476	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.972
F6QHP8_CIOIN	LOC100177845	ENSCINP00000016900	ENSCINP00000004488	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	acetyl-CoA acetyltransferase, mitochondrial-like; Belongs to the thiolase-like superfamily. Thiolase family.	0.683
F6QHP8_CIOIN	LOC113474070	ENSCINP00000016900	ENSCINP00000005299	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.972
F6QM57_CIOIN	F6Z0U1_CIOIN	ENSCINP00000020126	ENSCINP00000010736	Prenylcys_lyase domain-containing protein.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.572
F6QM57_CIOIN	LOC100176674	ENSCINP00000020126	ENSCINP00000012053	Prenylcys_lyase domain-containing protein.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.449
F6RX41_CIOIN	F6Z0U1_CIOIN	ENSCINP00000022634	ENSCINP00000010736	Uncharacterized protein.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.433