STRINGSTRING
Tgfbr-iib Tgfbr-iib LOC100180632 LOC100180632 cdc42 cdc42 LOC100179260 LOC100179260 capza capza F6S9U6_CIOIN F6S9U6_CIOIN LOC100177697 LOC100177697 F6VL21_CIOIN F6VL21_CIOIN F6UK45_CIOIN F6UK45_CIOIN F7AMF6_CIOIN F7AMF6_CIOIN LOC100176247 LOC100176247 LOC100176145 LOC100176145 ci-arfgap-2 ci-arfgap-2 F6Q8V1_CIOIN F6Q8V1_CIOIN F6YDP2_CIOIN F6YDP2_CIOIN ci-arfgap-3 ci-arfgap-3 LOC100184914 LOC100184914 tgfbr-ic tgfbr-ic F6SCE7_CIOIN F6SCE7_CIOIN Arfgap-10 Arfgap-10 rhoc rhoc F6WMZ2_CIOIN F6WMZ2_CIOIN LOC100182193 LOC100182193 F6XLF0_CIOIN F6XLF0_CIOIN LOC100185418 LOC100185418 LOC100185758 LOC100185758 LOC100175009 LOC100175009 F6VY76_CIOIN F6VY76_CIOIN F6YGR5_CIOIN F6YGR5_CIOIN LOC100179839 LOC100179839 F6U3B3_CIOIN F6U3B3_CIOIN LOC100182145 LOC100182145 LOC100176174 LOC100176174 F7A8L8_CIOIN F7A8L8_CIOIN LOC104266814 LOC104266814 LOC100176748 LOC100176748 F6QNM6_CIOIN F6QNM6_CIOIN LOC100182764 LOC100182764 F6TYR7_CIOIN F6TYR7_CIOIN H2XJF3_CIOIN H2XJF3_CIOIN LOC100182217 LOC100182217 F6VBD5_CIOIN F6VBD5_CIOIN LOC100185661 LOC100185661 F6V899_CIOIN F6V899_CIOIN LOC100182553 LOC100182553 F7ACG4_CIOIN F7ACG4_CIOIN LOC100178018 LOC100178018 LOC100183161 LOC100183161 hsp70 hsp70 capzb capzb LOC100178291 LOC100178291 LOC100176704 LOC100176704 Arfgap-6 Arfgap-6 LOC100178575 LOC100178575 zf(fyve)-11 zf(fyve)-11 LOC100180144 LOC100180144 F6UP73_CIOIN F6UP73_CIOIN ci-arfgap-11 ci-arfgap-11 F6YAC3_CIOIN F6YAC3_CIOIN LOC100181786 LOC100181786 LOC100178195 LOC100178195 LOC100183094 LOC100183094 F6W446_CIOIN F6W446_CIOIN F6VHM6_CIOIN F6VHM6_CIOIN LOC445704 LOC445704 LOC100183241 LOC100183241 LOC100187210 LOC100187210 LOC100182534 LOC100182534 F6PHZ4_CIOIN F6PHZ4_CIOIN LOC100181722 LOC100181722 LOC100178975 LOC100178975 Ci-ArfGAP-8 Ci-ArfGAP-8 LOC100179674 LOC100179674 F6XUK1_CIOIN F6XUK1_CIOIN LOC100183675 LOC100183675 F7AWH6_CIOIN F7AWH6_CIOIN LOC100179535 LOC100179535 F7BDH1_CIOIN F7BDH1_CIOIN F7A912_CIOIN F7A912_CIOIN LOC100175425 LOC100175425 LOC100183862 LOC100183862 LOC100180447 LOC100180447 F6W8P3_CIOIN F6W8P3_CIOIN LOC100180662 LOC100180662 Ciarr Ciarr LOC100185572 LOC100185572 H2XJG0_CIOIN H2XJG0_CIOIN LOC100187027 LOC100187027 Q1RPY5_CIOIN Q1RPY5_CIOIN LOC104266462 LOC104266462 LOC100177673 LOC100177673 H2XPM9_CIOIN H2XPM9_CIOIN H2XQB6_CIOIN H2XQB6_CIOIN LOC104266244 LOC104266244 LOC100185040 LOC100185040 H2XRF4_CIOIN H2XRF4_CIOIN H2XRX8_CIOIN H2XRX8_CIOIN LOC100178401 LOC100178401 H2XUI9_CIOIN H2XUI9_CIOIN ar20 ar20 H2XWC0_CIOIN H2XWC0_CIOIN H2XWW7_CIOIN H2XWW7_CIOIN H2XX22_CIOIN H2XX22_CIOIN H2Y030_CIOIN H2Y030_CIOIN LOC100184752 LOC100184752 H2Y130_CIOIN H2Y130_CIOIN LOC100185836 LOC100185836 LOC100175056 LOC100175056 LOC100183914 LOC100183914 H2Y2H5_CIOIN H2Y2H5_CIOIN H2Y3B6_CIOIN H2Y3B6_CIOIN H2Y3F2_CIOIN H2Y3F2_CIOIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tgfbr-iibReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)
LOC100180632Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (804 aa)
cdc42Uncharacterized protein. (95 aa)
LOC100179260Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
capzaF-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (284 aa)
F6S9U6_CIOINSH3 domain-containing protein. (416 aa)
LOC100177697Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
F6VL21_CIOING protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (591 aa)
F6UK45_CIOINKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (860 aa)
F7AMF6_CIOINClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1635 aa)
LOC100176247Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (179 aa)
LOC100176145Sorting nexin-12-like isoform X1. (165 aa)
ci-arfgap-2Arf-GAP domain-containing protein. (300 aa)
F6Q8V1_CIOINFYVE-type domain-containing protein. (243 aa)
F6YDP2_CIOINUncharacterized protein. (445 aa)
ci-arfgap-3Zinc finger protein Ci-ArfGAP-3. (760 aa)
LOC100184914Uncharacterized protein. (206 aa)
tgfbr-icReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
F6SCE7_CIOINUncharacterized protein. (361 aa)
Arfgap-10Arf-GAP domain-containing protein. (563 aa)
rhocRhoA protein. (193 aa)
F6WMZ2_CIOINPIPK domain-containing protein. (453 aa)
LOC100182193Ras-related protein Rab-5B. (217 aa)
F6XLF0_CIOING protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (466 aa)
LOC100185418ADP-ribosylation factor 6-like; Belongs to the small GTPase superfamily. Arf family. (189 aa)
LOC100185758Ras-related protein Rab-10-like. (202 aa)
LOC100175009Partitioning defective protein 6. (372 aa)
F6VY76_CIOINUncharacterized protein. (210 aa)
F6YGR5_CIOINSorting nexin; Involved in several stages of intracellular trafficking. (410 aa)
LOC100179839Sorting nexin-4-like. (441 aa)
F6U3B3_CIOINUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (91 aa)
LOC100182145Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (366 aa)
LOC100176174Uncharacterized protein. (221 aa)
F7A8L8_CIOINUncharacterized protein. (519 aa)
LOC104266814ADP-ribosylation factor 6-like; Belongs to the small GTPase superfamily. Arf family. (174 aa)
LOC100176748Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (183 aa)
F6QNM6_CIOINSEC7 domain-containing protein. (609 aa)
LOC100182764Charged multivesicular body protein 5. (217 aa)
F6TYR7_CIOINUncharacterized protein. (567 aa)
H2XJF3_CIOINUncharacterized protein. (1127 aa)
LOC100182217ADP-ribosylation factor 4-like; Belongs to the small GTPase superfamily. Arf family. (180 aa)
F6VBD5_CIOINUncharacterized protein. (2263 aa)
LOC100185661Uncharacterized protein. (282 aa)
F6V899_CIOINUncharacterized protein. (371 aa)
LOC100182553AP-2 complex subunit mu isoform X3; Belongs to the adaptor complexes medium subunit family. (434 aa)
F7ACG4_CIOINWH2 domain-containing protein. (460 aa)
LOC100178018Uncharacterized protein. (225 aa)
LOC100183161Multivesicular body subunit 12B-like isoform X1. (248 aa)
hsp70Uncharacterized protein; Belongs to the heat shock protein 70 family. (627 aa)
capzbF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
LOC100178291Folate receptor gamma. (338 aa)
LOC100176704Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (248 aa)
Arfgap-6Uncharacterized protein. (868 aa)
LOC100178575Mothers against decapentaplegic homolog. (426 aa)
zf(fyve)-11Uncharacterized protein. (717 aa)
LOC100180144Vacuolar protein sorting-associated protein 4B-like; Belongs to the AAA ATPase family. (438 aa)
F6UP73_CIOINENTH domain-containing protein. (222 aa)
ci-arfgap-11Zinc finger protein Ci-ArfGAP-11. (990 aa)
F6YAC3_CIOINSenescence domain-containing protein. (116 aa)
LOC100181786Sorting nexin-5. (367 aa)
LOC100178195Rab11 family-interacting protein 1 isoform X1. (477 aa)
LOC100183094Ras-related protein rab7-like. (206 aa)
F6W446_CIOINE3 ubiquitin-protein ligase. (752 aa)
F6VHM6_CIOINAB hydrolase-1 domain-containing protein. (242 aa)
LOC445704TC10 protein. (193 aa)
LOC100183241Ras-related protein Rab-10-like isoform X1. (207 aa)
LOC100187210Uncharacterized protein; Belongs to the heat shock protein 70 family. (664 aa)
LOC100182534Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (208 aa)
F6PHZ4_CIOINUncharacterized protein. (266 aa)
LOC100181722WASH complex subunit 3-like. (196 aa)
LOC100178975Charged multivesicular body protein 2a-like. (222 aa)
Ci-ArfGAP-8Zinc finger protein. (1330 aa)
LOC100179674Vacuolar protein sorting-associated protein 37B-like. (252 aa)
F6XUK1_CIOINUncharacterized protein. (211 aa)
LOC100183675Folate_rec domain-containing protein. (257 aa)
F7AWH6_CIOINFolate_rec domain-containing protein. (230 aa)
LOC100179535Vacuolar protein sorting-associated protein 26B. (315 aa)
F7BDH1_CIOINBRO1 domain-containing protein. (902 aa)
F7A912_CIOINUncharacterized protein; Belongs to the peptidase C19 family. (1072 aa)
LOC100175425Ras-related protein Rab-11B-like. (217 aa)
LOC100183862Uncharacterized protein. (360 aa)
LOC100180447Rab11 family-interacting protein 3-like. (462 aa)
F6W8P3_CIOINUncharacterized protein. (202 aa)
LOC100180662Charged multivesicular body protein 6-B-like. (204 aa)
CiarrArrestin_C domain-containing protein. (253 aa)
LOC100185572Charged multivesicular body protein 4b-like isoform X1. (217 aa)
H2XJG0_CIOINRabaptin domain-containing protein. (368 aa)
LOC100187027AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
Q1RPY5_CIOINZinc finger protein. (579 aa)
LOC104266462ADP-ribosylation factor-like; Belongs to the small GTPase superfamily. Arf family. (200 aa)
LOC100177673Vacuolar protein-sorting-associated protein 25. (176 aa)
H2XPM9_CIOINUncharacterized protein. (209 aa)
H2XQB6_CIOINProtein kinase domain-containing protein. (130 aa)
LOC104266244Vacuolar protein sorting-associated protein VTA1 homolog. (291 aa)
LOC100185040Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
H2XRF4_CIOINUncharacterized protein. (451 aa)
H2XRX8_CIOINUncharacterized protein. (181 aa)
LOC100178401Uncharacterized protein. (250 aa)
H2XUI9_CIOINPDZ domain-containing protein. (219 aa)
ar20Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
H2XWC0_CIOINUncharacterized protein. (120 aa)
H2XWW7_CIOINUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (546 aa)
H2XX22_CIOINUncharacterized protein. (402 aa)
H2Y030_CIOINGLUE N-terminal domain-containing protein. (42 aa)
LOC100184752ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (182 aa)
H2Y130_CIOINUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (563 aa)
LOC100185836ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (196 aa)
LOC100175056WASH complex subunit 5 isoform X2. (1163 aa)
LOC100183914ADP-ribosylation factor 3; Belongs to the small GTPase superfamily. Arf family. (190 aa)
H2Y2H5_CIOINRGS domain-containing protein. (169 aa)
H2Y3B6_CIOINUncharacterized protein. (468 aa)
H2Y3F2_CIOINUncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (183 aa)
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
Server load: low (20%) [HD]