(69 nodes) Wnt signaling pathway network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100185055	Uncharacterized protein. (659 aa)
	Cigl	RING-type domain-containing protein. (631 aa)
	F6SF88_CIOIN	Phosphoinositide phospholipase C. (826 aa)
	wnt5	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	F6SE21_CIOIN	Uncharacterized protein. (611 aa)
	dickkopf	Dickkopf. (225 aa)
	LOC100181511	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (162 aa)
	gsk	Glycogen synthase kinase Alpha/beta. (407 aa)
	sfrp1/5	Secreted frizzled-related protein precursor. (365 aa)
	Tcf/lef	HMG box domain-containing protein. (351 aa)
	F6W6I5_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (477 aa)
	LOC778720	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (510 aa)
	LOC448957	Rac4 protein. (193 aa)
	Rac3a	Uncharacterized protein. (194 aa)
	LOC448958	Rac5 protein. (193 aa)
	LOC445702	Rac1 protein isoform X1. (192 aa)
	F6RA92_CIOIN	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
	Axin	Uncharacterized protein. (643 aa)
	rhoc	RhoA protein. (193 aa)
	F6R6F3_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1324 aa)
	F6XLJ0_CIOIN	Uncharacterized protein. (445 aa)
	ck2b	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
	LOC100183367	RuvB-like helicase; Belongs to the RuvB family. (456 aa)
	LOC100179165	R-spondin-3-like isoform X2. (251 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	nemo-like	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (403 aa)
	smad4	Mothers against decapentaplegic homolog. (527 aa)
	rcl2	Rac and Cdc42-like 2 protein isoform X1. (192 aa)
	Tak1/mapkkk7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (190 aa)
	Wnt-a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
	LOC100178575	Mothers against decapentaplegic homolog. (426 aa)
	F6PUP9_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (708 aa)
	LOC100176009	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (367 aa)
	Pk1	Uncharacterized protein. (1060 aa)
	F6TZD2_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (175 aa)
	Ci-APC	Adenomatosis polyposis coli. (495 aa)
	Cifrz	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (866 aa)
	Cibeta-catenin	Uncharacterized protein. (497 aa)
	F6W3R8_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (317 aa)
	F6S5E1_CIOIN	Uncharacterized protein. (221 aa)
	F6Q7C4_CIOIN	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (262 aa)
	F6XRM1_CIOIN	Uncharacterized protein. (229 aa)
	LOC100177957	Tyrosine-protein kinase RYK. (593 aa)
	jun	Transcription factor protein. (381 aa)
	betaTrCP	Beta-transducin repeat-containing HOMOLOGUE protein. (621 aa)
	Jnk	Mitogen-activated protein kinase. (437 aa)
	ck2a	Casein kinase 2 alpha subunit; Belongs to the protein kinase superfamily. (385 aa)
	dsh	Dishevelled homolog. (685 aa)
	F6Y940_CIOIN	Serine/threonine-protein phosphatase. (241 aa)
	Q4H307_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (249 aa)
	F6X6P0_CIOIN	Uncharacterized protein. (1145 aa)
	LOC100184556	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (442 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (304 aa)
	F6VUF1_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (608 aa)
	Rac2	Uncharacterized protein. (192 aa)
	F6ZHF5_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC100185292	Uncharacterized protein LOC100185292. (195 aa)
	rcl1	Rac and Cdc42-like 1 protein. (194 aa)
	LOC100186373	G1/S-specific cyclin-D2-like; Belongs to the cyclin family. (299 aa)
	fz3/6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (810 aa)
	F7A3R0_CIOIN	Uncharacterized protein. (901 aa)
	LOC100178548	R-spondin-3-like. (171 aa)
	H2XKU5_CIOIN	Uncharacterized protein. (147 aa)
	H2XMN9_CIOIN	Drf_GBD domain-containing protein. (189 aa)
	LOC100182516	RING-box protein 1. (104 aa)
	Q4H306_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
	LOC100176189	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (285 aa)
	LOC100187330	Calcineurin subunit B type 1. (170 aa)
	Fz4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (339 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Axin	Ci-APC	ENSCINP00000005332	ENSCINP00000014032	Uncharacterized protein.	Adenomatosis polyposis coli.	0.900
Axin	Cibeta-catenin	ENSCINP00000005332	ENSCINP00000014417	Uncharacterized protein.	Uncharacterized protein.	0.997
Axin	Cifrz	ENSCINP00000005332	ENSCINP00000014064	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.508
Axin	F6PUP9_CIOIN	ENSCINP00000005332	ENSCINP00000013382	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.504
Axin	F6Q7C4_CIOIN	ENSCINP00000005332	ENSCINP00000016982	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.532
Axin	F6TZD2_CIOIN	ENSCINP00000005332	ENSCINP00000013998	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.513
Axin	F6VUF1_CIOIN	ENSCINP00000005332	ENSCINP00000024011	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.434
Axin	F6W3R8_CIOIN	ENSCINP00000005332	ENSCINP00000016371	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.983
Axin	F6X6P0_CIOIN	ENSCINP00000005332	ENSCINP00000022785	Uncharacterized protein.	Uncharacterized protein.	0.519
Axin	F6ZHF5_CIOIN	ENSCINP00000005332	ENSCINP00000024208	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.432
Axin	F7A3R0_CIOIN	ENSCINP00000005332	ENSCINP00000027515	Uncharacterized protein.	Uncharacterized protein.	0.699
Axin	LOC100176189	ENSCINP00000005332	ENSCINP00000034692	Uncharacterized protein.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.481
Axin	LOC100181511	ENSCINP00000005332	ENSCINP00000003403	Uncharacterized protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.653
Axin	LOC778720	ENSCINP00000005332	ENSCINP00000004395	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.501
Axin	Q4H307_CIOIN	ENSCINP00000005332	ENSCINP00000022071	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.501
Axin	Tcf/lef	ENSCINP00000005332	ENSCINP00000004053	Uncharacterized protein.	HMG box domain-containing protein.	0.789
Axin	betaTrCP	ENSCINP00000005332	ENSCINP00000018885	Uncharacterized protein.	Beta-transducin repeat-containing HOMOLOGUE protein.	0.913
Axin	dsh	ENSCINP00000005332	ENSCINP00000019640	Uncharacterized protein.	Dishevelled homolog.	0.995
Axin	gsk	ENSCINP00000005332	ENSCINP00000003673	Uncharacterized protein.	Glycogen synthase kinase Alpha/beta.	0.999
Axin	nemo-like	ENSCINP00000005332	ENSCINP00000011009	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.491