(16 nodes) Mixed, incl. RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3XXY9_BRAFL	Uncharacterized protein. (145 aa)
	C3YBL3_BRAFL	Uncharacterized protein. (1267 aa)
	C3YI31_BRAFL	DUF1767 domain-containing protein. (184 aa)
	C3YKR1_BRAFL	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (666 aa)
	C3YUN6_BRAFL	Uncharacterized protein. (118 aa)
	C3YVY6_BRAFL	RECA_2 domain-containing protein. (103 aa)
	C3YZM5_BRAFL	Uncharacterized protein. (453 aa)
	C3Z3N5_BRAFL	Spc7 domain-containing protein. (1713 aa)
	C3Z741_BRAFL	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (346 aa)
	C3Z742_BRAFL	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (684 aa)
	C3ZEC9_BRAFL	Uncharacterized protein. (594 aa)
	C3ZHV8_BRAFL	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (265 aa)
	C3ZHV9_BRAFL	Uncharacterized protein. (256 aa)
	C3ZUB7_BRAFL	Uncharacterized protein. (235 aa)
	C3ZYG2_BRAFL	Uncharacterized protein. (561 aa)
	C3ZZH4_BRAFL	Uncharacterized protein. (541 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XXY9_BRAFL	C3YBL3_BRAFL	C3XXY9	C3YBL3	Uncharacterized protein.	Uncharacterized protein.	0.585
C3XXY9_BRAFL	C3YI31_BRAFL	C3XXY9	C3YI31	Uncharacterized protein.	DUF1767 domain-containing protein.	0.998
C3XXY9_BRAFL	C3YKR1_BRAFL	C3XXY9	C3YKR1	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.662
C3XXY9_BRAFL	C3YUN6_BRAFL	C3XXY9	C3YUN6	Uncharacterized protein.	Uncharacterized protein.	0.638
C3XXY9_BRAFL	C3YVY6_BRAFL	C3XXY9	C3YVY6	Uncharacterized protein.	RECA_2 domain-containing protein.	0.690
C3XXY9_BRAFL	C3YZM5_BRAFL	C3XXY9	C3YZM5	Uncharacterized protein.	Uncharacterized protein.	0.662
C3XXY9_BRAFL	C3Z3N5_BRAFL	C3XXY9	C3Z3N5	Uncharacterized protein.	Spc7 domain-containing protein.	0.688
C3XXY9_BRAFL	C3Z741_BRAFL	C3XXY9	C3Z741	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.876
C3XXY9_BRAFL	C3Z742_BRAFL	C3XXY9	C3Z742	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.876
C3XXY9_BRAFL	C3ZEC9_BRAFL	C3XXY9	C3ZEC9	Uncharacterized protein.	Uncharacterized protein.	0.968
C3XXY9_BRAFL	C3ZHV8_BRAFL	C3XXY9	C3ZHV8	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.656
C3XXY9_BRAFL	C3ZHV9_BRAFL	C3XXY9	C3ZHV9	Uncharacterized protein.	Uncharacterized protein.	0.543
C3XXY9_BRAFL	C3ZUB7_BRAFL	C3XXY9	C3ZUB7	Uncharacterized protein.	Uncharacterized protein.	0.550
C3XXY9_BRAFL	C3ZYG2_BRAFL	C3XXY9	C3ZYG2	Uncharacterized protein.	Uncharacterized protein.	0.550
C3XXY9_BRAFL	C3ZZH4_BRAFL	C3XXY9	C3ZZH4	Uncharacterized protein.	Uncharacterized protein.	0.971
C3YBL3_BRAFL	C3XXY9_BRAFL	C3YBL3	C3XXY9	Uncharacterized protein.	Uncharacterized protein.	0.585
C3YBL3_BRAFL	C3YI31_BRAFL	C3YBL3	C3YI31	Uncharacterized protein.	DUF1767 domain-containing protein.	0.940
C3YBL3_BRAFL	C3YKR1_BRAFL	C3YBL3	C3YKR1	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.586
C3YBL3_BRAFL	C3YUN6_BRAFL	C3YBL3	C3YUN6	Uncharacterized protein.	Uncharacterized protein.	0.994
C3YBL3_BRAFL	C3YVY6_BRAFL	C3YBL3	C3YVY6	Uncharacterized protein.	RECA_2 domain-containing protein.	0.737