(34 nodes) Purine metabolism network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	C3XQH1_BRAFL	PfkB domain-containing protein. (349 aa)
	C3XR57_BRAFL	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. (435 aa)
	C3XSP8_BRAFL	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (456 aa)
	C3XUB4_BRAFL	Pribosyltran domain-containing protein. (183 aa)
	C3XUP3_BRAFL	A_deaminase domain-containing protein. (346 aa)
	C3XUZ8_BRAFL	dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (116 aa)
	C3XY60_BRAFL	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (393 aa)
	C3Y3U8_BRAFL	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (100 aa)
	C3Y400_BRAFL	Uncharacterized protein. (344 aa)
	C3Y401_BRAFL	Uncharacterized protein. (196 aa)
	C3Y4K4_BRAFL	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (241 aa)
	C3YCI9_BRAFL	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
	C3YEM4_BRAFL	Guanylate kinase-like domain-containing protein. (223 aa)
	C3YGH6_BRAFL	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (487 aa)
	C3YHC9_BRAFL	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (588 aa)
	C3YQ71_BRAFL	Uncharacterized protein. (467 aa)
	C3YRI7_BRAFL	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (515 aa)
	C3YTT3_BRAFL	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)
	C3YVB0_BRAFL	Nudix hydrolase domain-containing protein. (196 aa)
	C3YWE5_BRAFL	Uncharacterized protein. (208 aa)
	C3Z429_BRAFL	Uncharacterized protein. (512 aa)
	C3Z4P7_BRAFL	Pribosyltran domain-containing protein. (185 aa)
	C3Z5T1_BRAFL	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (343 aa)
	C3Z6Z0_BRAFL	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
	C3Z8U1_BRAFL	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (513 aa)
	C3ZD91_BRAFL	Uncharacterized protein. (305 aa)
	C3ZD93_BRAFL	Uncharacterized protein. (347 aa)
	C3ZGM9_BRAFL	Uncharacterized protein. (146 aa)
	C3ZIB1_BRAFL	MGS domain-containing protein. (593 aa)
	C3ZIC1_BRAFL	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (265 aa)
	C3ZMK0_BRAFL	Uncharacterized protein. (688 aa)
	C3ZRF7_BRAFL	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (346 aa)
	C3ZT93_BRAFL	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (889 aa)
	C3ZWY5_BRAFL	Uncharacterized protein. (331 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XQH1_BRAFL	C3XR57_BRAFL	C3XQH1	C3XR57	PfkB domain-containing protein.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis.	0.778
C3XQH1_BRAFL	C3XSP8_BRAFL	C3XQH1	C3XSP8	PfkB domain-containing protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.917
C3XQH1_BRAFL	C3XUB4_BRAFL	C3XQH1	C3XUB4	PfkB domain-containing protein.	Pribosyltran domain-containing protein.	0.959
C3XQH1_BRAFL	C3XUP3_BRAFL	C3XQH1	C3XUP3	PfkB domain-containing protein.	A_deaminase domain-containing protein.	0.967
C3XQH1_BRAFL	C3XY60_BRAFL	C3XQH1	C3XY60	PfkB domain-containing protein.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.920
C3XQH1_BRAFL	C3Y401_BRAFL	C3XQH1	C3Y401	PfkB domain-containing protein.	Uncharacterized protein.	0.906
C3XQH1_BRAFL	C3Y4K4_BRAFL	C3XQH1	C3Y4K4	PfkB domain-containing protein.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.973
C3XQH1_BRAFL	C3YCI9_BRAFL	C3XQH1	C3YCI9	PfkB domain-containing protein.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.943
C3XQH1_BRAFL	C3YGH6_BRAFL	C3XQH1	C3YGH6	PfkB domain-containing protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.917
C3XQH1_BRAFL	C3YHC9_BRAFL	C3XQH1	C3YHC9	PfkB domain-containing protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.917
C3XQH1_BRAFL	C3YRI7_BRAFL	C3XQH1	C3YRI7	PfkB domain-containing protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.917
C3XQH1_BRAFL	C3YWE5_BRAFL	C3XQH1	C3YWE5	PfkB domain-containing protein.	Uncharacterized protein.	0.902
C3XQH1_BRAFL	C3Z429_BRAFL	C3XQH1	C3Z429	PfkB domain-containing protein.	Uncharacterized protein.	0.969
C3XQH1_BRAFL	C3Z4P7_BRAFL	C3XQH1	C3Z4P7	PfkB domain-containing protein.	Pribosyltran domain-containing protein.	0.959
C3XQH1_BRAFL	C3Z5T1_BRAFL	C3XQH1	C3Z5T1	PfkB domain-containing protein.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.914
C3XQH1_BRAFL	C3Z6Z0_BRAFL	C3XQH1	C3Z6Z0	PfkB domain-containing protein.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.977
C3XQH1_BRAFL	C3Z8U1_BRAFL	C3XQH1	C3Z8U1	PfkB domain-containing protein.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.917
C3XQH1_BRAFL	C3ZD91_BRAFL	C3XQH1	C3ZD91	PfkB domain-containing protein.	Uncharacterized protein.	0.902
C3XQH1_BRAFL	C3ZD93_BRAFL	C3XQH1	C3ZD93	PfkB domain-containing protein.	Uncharacterized protein.	0.902
C3XQH1_BRAFL	C3ZGM9_BRAFL	C3XQH1	C3ZGM9	PfkB domain-containing protein.	Uncharacterized protein.	0.900