(73 nodes) Mixed, incl. Iron-sulfur cluster assembly, and Nitric oxide metabolic process network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3XQE5_BRAFL	Nfu_N domain-containing protein. (263 aa)
	C3XR88_BRAFL	MOSC domain-containing protein. (329 aa)
	C3XR89_BRAFL	MOSC domain-containing protein. (329 aa)
	C3XRN9_BRAFL	Elp3 domain-containing protein. (657 aa)
	C3XRT0_BRAFL	DUF3641 domain-containing protein. (472 aa)
	C3XU95_BRAFL	FeS_assembly_P domain-containing protein. (171 aa)
	C3XUB6_BRAFL	Aminotran_5 domain-containing protein. (402 aa)
	C3XVJ8_BRAFL	FAD-binding FR-type domain-containing protein. (502 aa)
	C3XW11_BRAFL	NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (163 aa)
	C3XZE3_BRAFL	MoCF_biosynth domain-containing protein. (110 aa)
	C3XZE4_BRAFL	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (430 aa)
	C3Y0N0_BRAFL	MOSC domain-containing protein. (327 aa)
	C3Y0S2_BRAFL	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily. (152 aa)
	C3Y1Q5_BRAFL	Porphobil_deam domain-containing protein. (140 aa)
	C3Y1R3_BRAFL	FeS_assembly_P domain-containing protein. (172 aa)
	C3Y301_BRAFL	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (197 aa)
	LIAS_BRAFL	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. (376 aa)
	C3Y413_BRAFL	Methyltranfer_dom domain-containing protein. (378 aa)
	C3Y4I9_BRAFL	Uncharacterized protein. (364 aa)
	C3Y4T1_BRAFL	Flavodoxin-like domain-containing protein. (952 aa)
	C3Y524_BRAFL	Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
	C3Y5A8_BRAFL	HEM4 domain-containing protein. (205 aa)
	C3Y5C4_BRAFL	BPL/LPL catalytic domain-containing protein. (600 aa)
	C3Y5M1_BRAFL	zf-NOSIP domain-containing protein. (272 aa)
	C3Y6H7_BRAFL	Uncharacterized protein. (326 aa)
	C3Y8I4_BRAFL	Cytochrome b5; Belongs to the cytochrome b5 family. (138 aa)
	C3Y979_BRAFL	VWFA domain-containing protein. (152 aa)
	C3Y980_BRAFL	Uncharacterized protein. (388 aa)
	C3Y983_BRAFL	Uncharacterized protein. (642 aa)
	NosC	Uncharacterized protein. (1441 aa)
	C3YE11_BRAFL	Uncharacterized protein. (250 aa)
	C3YEA4_BRAFL	BPL/LPL catalytic domain-containing protein. (217 aa)
	C3YF45_BRAFL	Uncharacterized protein. (411 aa)
	DRE2_BRAFL	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (309 aa)
	C3YH68_BRAFL	Uncharacterized protein. (824 aa)
	C3YHI6_BRAFL	Uncharacterized protein. (469 aa)
	C3YI08_BRAFL	Ig-like domain-containing protein. (768 aa)
	C3YIV0_BRAFL	Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (342 aa)
	C3YP26_BRAFL	Uncharacterized protein. (875 aa)
	C3YPR2_BRAFL	Uncharacterized protein. (863 aa)
	C3YPS3_BRAFL	AAA domain-containing protein. (290 aa)
	C3YQ73_BRAFL	MoCF_biosynth domain-containing protein. (501 aa)
	C3YQR2_BRAFL	2Fe-2S ferredoxin-type domain-containing protein. (162 aa)
	C3YQT2_BRAFL	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (368 aa)
	C3YWH8_BRAFL	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (287 aa)
	C3YXG3_BRAFL	Peptidyl-prolyl cis-trans isomerase. (56 aa)
	C3Z0S2_BRAFL	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (481 aa)
	C3Z367_BRAFL	Uncharacterized protein. (885 aa)
	C3Z3Q2_BRAFL	MOSC domain-containing protein. (304 aa)
	C3Z499_BRAFL	Uncharacterized protein. (1170 aa)
	C3Z5H6_BRAFL	Uncharacterized protein; Belongs to the BolA/IbaG family. (105 aa)
	C3Z5W1_BRAFL	Uncharacterized protein. (610 aa)
	C3Z5W2_BRAFL	ATP-sulfurylase domain-containing protein. (171 aa)
	C3Z6S6_BRAFL	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family. (479 aa)
	C3Z6U6_BRAFL	Sulfurtransferase. (160 aa)
	C3Z6W5_BRAFL	Cytosolic Fe-S cluster assembly factor NUBP2 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (266 aa)
	C3Z6X6_BRAFL	FTCD_N domain-containing protein. (338 aa)
	C3Z9B8_BRAFL	Uncharacterized protein; Belongs to the BolA/IbaG family. (85 aa)
	C3ZBC0_BRAFL	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
	C3ZC55_BRAFL	GCV_T domain-containing protein. (441 aa)
	C3ZC60_BRAFL	Uncharacterized protein. (255 aa)
	C3ZE13_BRAFL	Methyltranfer_dom domain-containing protein. (276 aa)
	C3ZGM5_BRAFL	Uncharacterized protein. (132 aa)
	C3ZGY8_BRAFL	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (905 aa)
	C3ZJD9_BRAFL	Uncharacterized protein; Belongs to the ferrochelatase family. (402 aa)
	C3ZJU5_BRAFL	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (451 aa)
	C3ZKP5_BRAFL	Uncharacterized protein. (310 aa)
	C3ZPA6_BRAFL	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. (596 aa)
	C3ZPN8_BRAFL	Fe-S_biosyn domain-containing protein. (128 aa)
	C3ZS73_BRAFL	Uncharacterized protein. (1026 aa)
	C3ZSM6_BRAFL	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (475 aa)
	C3ZXJ0_BRAFL	NAD(P)-bd_dom domain-containing protein. (227 aa)
	C3ZYC8_BRAFL	Thioesterase domain-containing protein. (253 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XQE5_BRAFL	C3XRT0_BRAFL	C3XQE5	C3XRT0	Nfu_N domain-containing protein.	DUF3641 domain-containing protein.	0.709
C3XQE5_BRAFL	C3XUB6_BRAFL	C3XQE5	C3XUB6	Nfu_N domain-containing protein.	Aminotran_5 domain-containing protein.	0.934
C3XQE5_BRAFL	C3XW11_BRAFL	C3XQE5	C3XW11	Nfu_N domain-containing protein.	NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.886
C3XQE5_BRAFL	C3Y0S2_BRAFL	C3XQE5	C3Y0S2	Nfu_N domain-containing protein.	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	0.508
C3XQE5_BRAFL	C3Y4I9_BRAFL	C3XQE5	C3Y4I9	Nfu_N domain-containing protein.	Uncharacterized protein.	0.842
C3XQE5_BRAFL	C3Y5A8_BRAFL	C3XQE5	C3Y5A8	Nfu_N domain-containing protein.	HEM4 domain-containing protein.	0.462
C3XQE5_BRAFL	C3Y5C4_BRAFL	C3XQE5	C3Y5C4	Nfu_N domain-containing protein.	BPL/LPL catalytic domain-containing protein.	0.510
C3XQE5_BRAFL	C3Y6H7_BRAFL	C3XQE5	C3Y6H7	Nfu_N domain-containing protein.	Uncharacterized protein.	0.808
C3XQE5_BRAFL	C3YEA4_BRAFL	C3XQE5	C3YEA4	Nfu_N domain-containing protein.	BPL/LPL catalytic domain-containing protein.	0.707
C3XQE5_BRAFL	C3YH68_BRAFL	C3XQE5	C3YH68	Nfu_N domain-containing protein.	Uncharacterized protein.	0.685
C3XQE5_BRAFL	C3YI08_BRAFL	C3XQE5	C3YI08	Nfu_N domain-containing protein.	Ig-like domain-containing protein.	0.842
C3XQE5_BRAFL	C3YQR2_BRAFL	C3XQE5	C3YQR2	Nfu_N domain-containing protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.556
C3XQE5_BRAFL	C3YXG3_BRAFL	C3XQE5	C3YXG3	Nfu_N domain-containing protein.	Peptidyl-prolyl cis-trans isomerase.	0.406
C3XQE5_BRAFL	C3Z367_BRAFL	C3XQE5	C3Z367	Nfu_N domain-containing protein.	Uncharacterized protein.	0.444
C3XQE5_BRAFL	C3Z5H6_BRAFL	C3XQE5	C3Z5H6	Nfu_N domain-containing protein.	Uncharacterized protein; Belongs to the BolA/IbaG family.	0.709
C3XQE5_BRAFL	C3Z6S6_BRAFL	C3XQE5	C3Z6S6	Nfu_N domain-containing protein.	Fe_hyd_SSU domain-containing protein; Belongs to the NARF family.	0.532
C3XQE5_BRAFL	C3Z9B8_BRAFL	C3XQE5	C3Z9B8	Nfu_N domain-containing protein.	Uncharacterized protein; Belongs to the BolA/IbaG family.	0.591
C3XQE5_BRAFL	C3ZC55_BRAFL	C3XQE5	C3ZC55	Nfu_N domain-containing protein.	GCV_T domain-containing protein.	0.535
C3XQE5_BRAFL	C3ZC60_BRAFL	C3XQE5	C3ZC60	Nfu_N domain-containing protein.	Uncharacterized protein.	0.535
C3XQE5_BRAFL	C3ZGM5_BRAFL	C3XQE5	C3ZGM5	Nfu_N domain-containing protein.	Uncharacterized protein.	0.810