(51 nodes) Mixed, incl. Anaphase-promoting complex, and Cyclin-dependent protein kinase holoenzyme complex network (Branchiostoma floridae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3XQE9_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (305 aa)
	C3XU15_BRAFL	Uncharacterized protein. (1053 aa)
	C3XWF2_BRAFL	PDZ domain-containing protein. (260 aa)
	C3XWG1_BRAFL	ANK_REP_REGION domain-containing protein. (925 aa)
	C3XZV1_BRAFL	PDZ domain-containing protein. (849 aa)
	C3Y0L2_BRAFL	APC1_C domain-containing protein. (2078 aa)
	C3Y0R7_BRAFL	ANAPC5 domain-containing protein. (747 aa)
	C3Y135_BRAFL	Protein kinase domain-containing protein. (239 aa)
	C3Y3A4_BRAFL	Uncharacterized protein. (110 aa)
	C3Y3Y6_BRAFL	Uncharacterized protein. (675 aa)
	C3Y411_BRAFL	E2F_CC-MB domain-containing protein. (284 aa)
	C3Y5M5_BRAFL	Protein kinase domain-containing protein. (595 aa)
	C3Y5S4_BRAFL	Uncharacterized protein. (334 aa)
	C3Y7K0_BRAFL	Wee1-like protein kinase. (556 aa)
	C3Y9K6_BRAFL	Uncharacterized protein. (846 aa)
	C3YAA3_BRAFL	AA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (1128 aa)
	C3YCQ9_BRAFL	Uncharacterized protein. (545 aa)
	C3YDJ3_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (495 aa)
	C3YEG7_BRAFL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
	C3YIF0_BRAFL	Uncharacterized protein. (721 aa)
	C3YJ59_BRAFL	CYCLIN domain-containing protein; Belongs to the cyclin family. (208 aa)
	C3YJJ8_BRAFL	Uncharacterized protein. (359 aa)
	C3YJL2_BRAFL	Uncharacterized protein. (355 aa)
	C3YK31_BRAFL	Uncharacterized protein. (537 aa)
	C3YLS9_BRAFL	Uncharacterized protein. (325 aa)
	C3YNN9_BRAFL	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (82 aa)
	C3YTV7_BRAFL	CULLIN_2 domain-containing protein; Belongs to the cullin family. (818 aa)
	C3YUU6_BRAFL	Uncharacterized protein. (232 aa)
	C3YWT5_BRAFL	C2H2-type domain-containing protein. (540 aa)
	C3YYG5_BRAFL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (131 aa)
	C3YYJ5_BRAFL	Uncharacterized protein. (492 aa)
	C3YYK3_BRAFL	TPR_REGION domain-containing protein. (854 aa)
	C3YYZ3_BRAFL	Cyclin_C domain-containing protein. (189 aa)
	C3YZJ9_BRAFL	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (181 aa)
	C3YZV0_BRAFL	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (320 aa)
	C3Z068_BRAFL	GLTSCR1 domain-containing protein. (1731 aa)
	UBE2S_BRAFL	Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (213 aa)
	C3Z8A2_BRAFL	RB_A domain-containing protein. (305 aa)
	C3Z917_BRAFL	Protein kinase domain-containing protein. (450 aa)
	C3ZBS5_BRAFL	E2F_TDP domain-containing protein. (327 aa)
	C3ZBU1_BRAFL	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (412 aa)
	C3ZDV9_BRAFL	PHD-type domain-containing protein. (295 aa)
	C3ZJB9_BRAFL	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (74 aa)
	C3ZKU4_BRAFL	Uncharacterized protein. (103 aa)
	C3ZLP9_BRAFL	TPR_REGION domain-containing protein. (575 aa)
	C3ZMG1_BRAFL	E2F_TDP domain-containing protein. (280 aa)
	C3ZMX8_BRAFL	Uncharacterized protein. (81 aa)
	C3ZNJ6_BRAFL	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	C3ZSX0_BRAFL	CYCLIN domain-containing protein; Belongs to the cyclin family. (317 aa)
	C3ZSX1_BRAFL	CYCLIN domain-containing protein; Belongs to the cyclin family. (344 aa)
	C3ZTE5_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (321 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XQE9_BRAFL	C3XU15_BRAFL	C3XQE9	C3XU15	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.838
C3XQE9_BRAFL	C3XWF2_BRAFL	C3XQE9	C3XWF2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	PDZ domain-containing protein.	0.779
C3XQE9_BRAFL	C3XZV1_BRAFL	C3XQE9	C3XZV1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	PDZ domain-containing protein.	0.779
C3XQE9_BRAFL	C3Y0L2_BRAFL	C3XQE9	C3Y0L2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC1_C domain-containing protein.	0.840
C3XQE9_BRAFL	C3Y0R7_BRAFL	C3XQE9	C3Y0R7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	ANAPC5 domain-containing protein.	0.620
C3XQE9_BRAFL	C3Y3A4_BRAFL	C3XQE9	C3Y3A4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.502
C3XQE9_BRAFL	C3Y3Y6_BRAFL	C3XQE9	C3Y3Y6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.732
C3XQE9_BRAFL	C3Y411_BRAFL	C3XQE9	C3Y411	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	E2F_CC-MB domain-containing protein.	0.604
C3XQE9_BRAFL	C3Y5M5_BRAFL	C3XQE9	C3Y5M5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.412
C3XQE9_BRAFL	C3Y5S4_BRAFL	C3XQE9	C3Y5S4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.769
C3XQE9_BRAFL	C3Y7K0_BRAFL	C3XQE9	C3Y7K0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Wee1-like protein kinase.	0.834
C3XQE9_BRAFL	C3YAA3_BRAFL	C3XQE9	C3YAA3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	AA_TRNA_LIGASE_II_ALA domain-containing protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.	0.557
C3XQE9_BRAFL	C3YCQ9_BRAFL	C3XQE9	C3YCQ9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.513
C3XQE9_BRAFL	C3YDJ3_BRAFL	C3XQE9	C3YDJ3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.821
C3XQE9_BRAFL	C3YEG7_BRAFL	C3XQE9	C3YEG7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.799
C3XQE9_BRAFL	C3YIF0_BRAFL	C3XQE9	C3YIF0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.808
C3XQE9_BRAFL	C3YJ59_BRAFL	C3XQE9	C3YJ59	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.783
C3XQE9_BRAFL	C3YJJ8_BRAFL	C3XQE9	C3YJJ8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.562
C3XQE9_BRAFL	C3YJL2_BRAFL	C3XQE9	C3YJL2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.562
C3XQE9_BRAFL	C3YK31_BRAFL	C3XQE9	C3YK31	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.813