(116 nodes) Regulation of DNA repair network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3Z0T4_BRAFL	LEDGF domain-containing protein. (390 aa)
	C3Z0T2_BRAFL	LEDGF domain-containing protein. (330 aa)
	C3Z057_BRAFL	TIMELESS domain-containing protein. (201 aa)
	C3Z054_BRAFL	Uncharacterized protein. (858 aa)
	C3YZS6_BRAFL	Uncharacterized protein. (425 aa)
	C3YZS4_BRAFL	Uncharacterized protein. (122 aa)
	C3YYL7_BRAFL	MCRS_N domain-containing protein. (235 aa)
	C3YYL6_BRAFL	FHA domain-containing protein. (204 aa)
	C3YXK5_BRAFL	UvrD_C_2 domain-containing protein. (1283 aa)
	C3YW92_BRAFL	DNA_binding_1 domain-containing protein. (166 aa)
	C3YW39_BRAFL	Uncharacterized protein. (2614 aa)
	C3YV86_BRAFL	Uncharacterized protein. (269 aa)
	C3YUP5_BRAFL	RING-type domain-containing protein. (184 aa)
	C3YTI8_BRAFL	Uncharacterized protein. (247 aa)
	C3YT49_BRAFL	Uncharacterized protein. (471 aa)
	C3YT07_BRAFL	Uncharacterized protein. (302 aa)
	C3YS35_BRAFL	RING-type domain-containing protein. (193 aa)
	C3YS13_BRAFL	RING-type domain-containing protein. (191 aa)
	C3YRX9_BRAFL	DTC domain-containing protein. (181 aa)
	C3YRX3_BRAFL	DTC domain-containing protein. (141 aa)
	C3YRX1_BRAFL	DTC domain-containing protein. (152 aa)
	C3YRW8_BRAFL	DTC domain-containing protein. (168 aa)
	C3YRW5_BRAFL	DTC domain-containing protein. (153 aa)
	C3YRW4_BRAFL	RING-type domain-containing protein. (190 aa)
	C3YLY7_BRAFL	Uncharacterized protein. (466 aa)
	C4A0H4_BRAFL	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
	C3ZYG2_BRAFL	Uncharacterized protein. (561 aa)
	C3ZXR0_BRAFL	RFX-type winged-helix domain-containing protein. (730 aa)
	C3ZXG4_BRAFL	Uncharacterized protein. (62 aa)
	C3ZUB7_BRAFL	Uncharacterized protein. (235 aa)
	C3ZS73_BRAFL	Uncharacterized protein. (1026 aa)
	C3ZS25_BRAFL	Uncharacterized protein. (2721 aa)
	C3ZS16_BRAFL	SMC hinge domain-containing protein. (1932 aa)
	C3ZR49_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (457 aa)
	C3ZR44_BRAFL	Uncharacterized protein. (122 aa)
	C3ZR41_BRAFL	FAT domain-containing protein. (3739 aa)
	C3ZMU1_BRAFL	Uncharacterized protein. (1878 aa)
	C3ZLP4_BRAFL	Uncharacterized protein; Belongs to the actin family. (424 aa)
	C3YS05_BRAFL	RING-type domain-containing protein. (188 aa)
	BABAM2	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (383 aa)
	C3XPH5_BRAFL	Uncharacterized protein. (501 aa)
	C3XQ87_BRAFL	Uncharacterized protein. (224 aa)
	C3XRL6_BRAFL	Uncharacterized protein. (299 aa)
	C3XS08_BRAFL	Uncharacterized protein. (644 aa)
	C3XS09_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
	C3XSK4_BRAFL	Uncharacterized protein. (961 aa)
	C3XU62_BRAFL	Uncharacterized protein. (1010 aa)
	C3XU65_BRAFL	BZIP domain-containing protein. (375 aa)
	C3XVD1_BRAFL	Uncharacterized protein. (3715 aa)
	C3XWH9_BRAFL	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (226 aa)
	C3XX89_BRAFL	Uncharacterized protein. (781 aa)
	C3XXY9_BRAFL	Uncharacterized protein. (145 aa)
	C3XY57_BRAFL	WD_REPEATS_REGION domain-containing protein. (397 aa)
	C3Y076_BRAFL	Uncharacterized protein. (467 aa)
	C3Y079_BRAFL	Ubiquitin thioesterase. (267 aa)
	C3Y0Y4_BRAFL	NFRKB_winged domain-containing protein. (1283 aa)
	C3Y124_BRAFL	Uncharacterized protein. (849 aa)
	C3Y1E5_BRAFL	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (603 aa)
	C3Y212_BRAFL	Deacetylase sirtuin-type domain-containing protein. (414 aa)
	C3Y2J9_BRAFL	ENDO3c domain-containing protein. (401 aa)
	C3Y332_BRAFL	Uncharacterized protein. (1237 aa)
	C3Y3I9_BRAFL	RING-type domain-containing protein. (180 aa)
	C3Y3J1_BRAFL	RING-type domain-containing protein. (180 aa)
	C3Y3J4_BRAFL	RING-type domain-containing protein. (198 aa)
	C3Y416_BRAFL	DTC domain-containing protein. (154 aa)
	C3Y429_BRAFL	Uncharacterized protein. (1173 aa)
	C3Y547_BRAFL	SET domain-containing protein. (312 aa)
	C3Y5Q2_BRAFL	Uncharacterized protein. (1122 aa)
	C3Y5W8_BRAFL	Uncharacterized protein. (635 aa)
	C3Y5X0_BRAFL	Macro domain-containing protein. (970 aa)
	C3Y696_BRAFL	Uncharacterized protein. (304 aa)
	C3Y6A4_BRAFL	RuvB-like helicase; Belongs to the RuvB family. (468 aa)
	C3Y6A6_BRAFL	Fork-head domain-containing protein. (84 aa)
	C3Y743_BRAFL	Uncharacterized protein. (287 aa)
	C3Y7G9_BRAFL	Uncharacterized protein. (227 aa)
	C3Y8U1_BRAFL	RING-type domain-containing protein. (178 aa)
	C3Y8U7_BRAFL	Uncharacterized protein. (430 aa)
	C3Y8U9_BRAFL	Uncharacterized protein. (418 aa)
	C3Y909_BRAFL	Deacetylase sirtuin-type domain-containing protein. (399 aa)
	C3Y9J6_BRAFL	HMG box domain-containing protein. (334 aa)
	C3YAW6_BRAFL	F-box domain-containing protein. (777 aa)
	C3YBF4_BRAFL	Uncharacterized protein. (2359 aa)
	C3YD16_BRAFL	Telo_bind domain-containing protein. (396 aa)
	C3YDF6_BRAFL	ANK_REP_REGION domain-containing protein. (91 aa)
	C3YDR2_BRAFL	YL1_C domain-containing protein. (310 aa)
	C3YEA6_BRAFL	WW domain-containing protein. (352 aa)
	C3YF62_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (311 aa)
	C3YF64_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4388 aa)
	C3YF65_BRAFL	Uncharacterized protein. (488 aa)
	C3YG90_BRAFL	FHA_2 domain-containing protein. (633 aa)
	C3YGI0_BRAFL	AAA domain-containing protein. (449 aa)
	C3YIV8_BRAFL	Uncharacterized protein. (1215 aa)
	C3YJQ0_BRAFL	MPN domain-containing protein. (268 aa)
	C3YK34_BRAFL	Uncharacterized protein. (2326 aa)
	C3YKN6_BRAFL	WD_REPEATS_REGION domain-containing protein. (665 aa)
	C3YKX2_BRAFL	Deacetylase sirtuin-type domain-containing protein. (312 aa)
	C3ZLH8_BRAFL	Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (804 aa)
	C3ZKZ0_BRAFL	Uncharacterized protein. (255 aa)
	C3ZGX7_BRAFL	Enhancer of polycomb-like protein. (730 aa)
	C3ZG27_BRAFL	Ubiquitin carboxyl-terminal hydrolase. (300 aa)
	C3ZF60_BRAFL	WD_REPEATS_REGION domain-containing protein. (434 aa)
	C3ZET3_BRAFL	RING-type domain-containing protein. (121 aa)
	C3ZET1_BRAFL	Uncharacterized protein. (632 aa)
	C3ZES4_BRAFL	Uncharacterized protein. (1579 aa)
	C3ZEP2_BRAFL	Uncharacterized protein. (344 aa)
	C3ZD30_BRAFL	Uncharacterized protein. (612 aa)
	C3ZCY5_BRAFL	Bromo domain-containing protein. (87 aa)
	C3ZC15_BRAFL	Uncharacterized protein. (260 aa)
	C3ZC14_BRAFL	KIND domain-containing protein. (209 aa)
	C3ZAT8_BRAFL	KIND domain-containing protein. (852 aa)
	C3Z749_BRAFL	Uncharacterized protein. (1464 aa)
	C3Z6T3_BRAFL	USP domain-containing protein. (892 aa)
	C3Z5C9_BRAFL	Uncharacterized protein. (496 aa)
	C3Z2P3_BRAFL	Poly [ADP-ribose] polymerase. (516 aa)
	C3Z273_BRAFL	SMC hinge domain-containing protein. (1148 aa)
	C3Z272_BRAFL	Uncharacterized protein. (725 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BABAM2	C3XRL6_BRAFL	B6NXD5	C3XRL6	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.543
BABAM2	C3YBF4_BRAFL	B6NXD5	C3YBF4	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.465
BABAM2	C3YJQ0_BRAFL	B6NXD5	C3YJQ0	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	MPN domain-containing protein.	0.986
BABAM2	C3YT07_BRAFL	B6NXD5	C3YT07	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YTI8_BRAFL	B6NXD5	C3YTI8	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YW39_BRAFL	B6NXD5	C3YW39	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.897
BABAM2	C3ZET3_BRAFL	B6NXD5	C3ZET3	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	RING-type domain-containing protein.	0.484
BABAM2	C3ZG27_BRAFL	B6NXD5	C3ZG27	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Ubiquitin carboxyl-terminal hydrolase.	0.438
C3XQ87_BRAFL	C3Y6A4_BRAFL	C3XQ87	C3Y6A4	Uncharacterized protein.	RuvB-like helicase; Belongs to the RuvB family.	0.987
C3XQ87_BRAFL	C3YDR2_BRAFL	C3XQ87	C3YDR2	Uncharacterized protein.	YL1_C domain-containing protein.	0.976
C3XQ87_BRAFL	C3YLY7_BRAFL	C3XQ87	C3YLY7	Uncharacterized protein.	Uncharacterized protein.	0.993
C3XQ87_BRAFL	C3YYL6_BRAFL	C3XQ87	C3YYL6	Uncharacterized protein.	FHA domain-containing protein.	0.562
C3XQ87_BRAFL	C3YYL7_BRAFL	C3XQ87	C3YYL7	Uncharacterized protein.	MCRS_N domain-containing protein.	0.562
C3XQ87_BRAFL	C3ZCY5_BRAFL	C3XQ87	C3ZCY5	Uncharacterized protein.	Bromo domain-containing protein.	0.935
C3XQ87_BRAFL	C3ZGX7_BRAFL	C3XQ87	C3ZGX7	Uncharacterized protein.	Enhancer of polycomb-like protein.	0.990
C3XQ87_BRAFL	C3ZLP4_BRAFL	C3XQ87	C3ZLP4	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.981
C3XQ87_BRAFL	C3ZR41_BRAFL	C3XQ87	C3ZR41	Uncharacterized protein.	FAT domain-containing protein.	0.948
C3XQ87_BRAFL	C3ZR44_BRAFL	C3XQ87	C3ZR44	Uncharacterized protein.	Uncharacterized protein.	0.891
C3XQ87_BRAFL	C3ZR49_BRAFL	C3XQ87	C3ZR49	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.891
C3XQ87_BRAFL	C3ZXG4_BRAFL	C3XQ87	C3ZXG4	Uncharacterized protein.	Uncharacterized protein.	0.954