(47 nodes) Negative regulation of G2/M transition of mitotic cell cycle network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BABAM2	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (383 aa)
	C3XRL6_BRAFL	Uncharacterized protein. (299 aa)
	C3XRW4_BRAFL	Uncharacterized protein. (496 aa)
	C3XS09_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
	C3XT78_BRAFL	Uncharacterized protein. (458 aa)
	C3Y089_BRAFL	WD_REPEATS_REGION domain-containing protein. (626 aa)
	C3Y0G6_BRAFL	RING-type domain-containing protein. (906 aa)
	C3Y0Z2_BRAFL	Uncharacterized protein. (386 aa)
	C3Y4U9_BRAFL	Uncharacterized protein. (120 aa)
	C3Y6Y9_BRAFL	Uncharacterized protein. (861 aa)
	C3Y6Z8_BRAFL	Uncharacterized protein. (972 aa)
	C3Y7M2_BRAFL	Uncharacterized protein; Belongs to the peptidase C19 family. (1318 aa)
	C3Y7Z7_BRAFL	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	C3Y8N4_BRAFL	Helicase C-terminal domain-containing protein. (591 aa)
	C3Y8U7_BRAFL	Uncharacterized protein. (430 aa)
	C3Y8U9_BRAFL	Uncharacterized protein. (418 aa)
	C3YDL0_BRAFL	Uncharacterized protein. (638 aa)
	C3YFD4_BRAFL	Uncharacterized protein. (489 aa)
	C3YFG1_BRAFL	FHA domain-containing protein. (721 aa)
	C3YH71_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (553 aa)
	C3YH73_BRAFL	FAT domain-containing protein. (2357 aa)
	C3YHB0_BRAFL	Uncharacterized protein. (681 aa)
	C3YIF0_BRAFL	Uncharacterized protein. (721 aa)
	C3YJD7_BRAFL	Uncharacterized protein. (719 aa)
	C3YJQ0_BRAFL	MPN domain-containing protein. (268 aa)
	C3YKR1_BRAFL	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (666 aa)
	C3YT07_BRAFL	Uncharacterized protein. (302 aa)
	C3YTI8_BRAFL	Uncharacterized protein. (247 aa)
	C3YW39_BRAFL	Uncharacterized protein. (2614 aa)
	C3YYJ5_BRAFL	Uncharacterized protein. (492 aa)
	C3YYS3_BRAFL	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (598 aa)
	C3YZM5_BRAFL	Uncharacterized protein. (453 aa)
	C3Z1H3_BRAFL	Uncharacterized protein. (270 aa)
	C3Z1H4_BRAFL	Uncharacterized protein. (1738 aa)
	C3Z2J8_BRAFL	Fork-head domain-containing protein. (191 aa)
	C3Z4C0_BRAFL	Protein kinase domain-containing protein. (934 aa)
	C3Z6I4_BRAFL	Uncharacterized protein. (107 aa)
	C3ZBQ9_BRAFL	Helicase ATP-binding domain-containing protein. (270 aa)
	C3ZEN4_BRAFL	Mre11_DNA_bind domain-containing protein. (441 aa)
	C3ZEP2_BRAFL	Uncharacterized protein. (344 aa)
	C3ZFR4_BRAFL	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (1032 aa)
	C3ZHI0_BRAFL	Helicase ATP-binding domain-containing protein. (504 aa)
	C3ZHN8_BRAFL	G-patch domain-containing protein. (364 aa)
	C3ZI04_BRAFL	Uncharacterized protein. (577 aa)
	C3ZMY3_BRAFL	Uncharacterized protein. (516 aa)
	C3ZR83_BRAFL	Uncharacterized protein. (459 aa)
	C3ZXK7_BRAFL	Uncharacterized protein. (1911 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BABAM2	C3XRL6_BRAFL	B6NXD5	C3XRL6	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.543
BABAM2	C3YFG1_BRAFL	B6NXD5	C3YFG1	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	FHA domain-containing protein.	0.475
BABAM2	C3YH71_BRAFL	B6NXD5	C3YH71	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.460
BABAM2	C3YH73_BRAFL	B6NXD5	C3YH73	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	FAT domain-containing protein.	0.460
BABAM2	C3YJQ0_BRAFL	B6NXD5	C3YJQ0	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	MPN domain-containing protein.	0.986
BABAM2	C3YT07_BRAFL	B6NXD5	C3YT07	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YTI8_BRAFL	B6NXD5	C3YTI8	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YW39_BRAFL	B6NXD5	C3YW39	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.897
BABAM2	C3ZEN4_BRAFL	B6NXD5	C3ZEN4	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Mre11_DNA_bind domain-containing protein.	0.469
C3XRL6_BRAFL	BABAM2	C3XRL6	B6NXD5	Uncharacterized protein.	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	0.543
C3XRL6_BRAFL	C3YFG1_BRAFL	C3XRL6	C3YFG1	Uncharacterized protein.	FHA domain-containing protein.	0.475
C3XRL6_BRAFL	C3YH71_BRAFL	C3XRL6	C3YH71	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.460
C3XRL6_BRAFL	C3YH73_BRAFL	C3XRL6	C3YH73	Uncharacterized protein.	FAT domain-containing protein.	0.460
C3XRL6_BRAFL	C3YJQ0_BRAFL	C3XRL6	C3YJQ0	Uncharacterized protein.	MPN domain-containing protein.	0.986
C3XRL6_BRAFL	C3YT07_BRAFL	C3XRL6	C3YT07	Uncharacterized protein.	Uncharacterized protein.	0.963
C3XRL6_BRAFL	C3YTI8_BRAFL	C3XRL6	C3YTI8	Uncharacterized protein.	Uncharacterized protein.	0.963
C3XRL6_BRAFL	C3YW39_BRAFL	C3XRL6	C3YW39	Uncharacterized protein.	Uncharacterized protein.	0.897
C3XRL6_BRAFL	C3ZEN4_BRAFL	C3XRL6	C3ZEN4	Uncharacterized protein.	Mre11_DNA_bind domain-containing protein.	0.469
C3XS09_BRAFL	C3XT78_BRAFL	C3XS09	C3XT78	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.554
C3XS09_BRAFL	C3Y089_BRAFL	C3XS09	C3Y089	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.784