(35 nodes) Stem cell population maintenance network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3Z5S8_BRAFL	Uncharacterized protein; Belongs to the argonaute family. (734 aa)
	C3ZBF3_BRAFL	Uncharacterized protein. (975 aa)
	C3ZF42_BRAFL	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1424 aa)
	C3ZG24_BRAFL	Uncharacterized protein. (536 aa)
	C3ZJH2_BRAFL	Uncharacterized protein. (269 aa)
	C3ZLC5_BRAFL	Uncharacterized protein. (221 aa)
	C3ZLC6_BRAFL	Uncharacterized protein. (219 aa)
	C3ZNA6_BRAFL	Uncharacterized protein. (294 aa)
	C3ZQG2_BRAFL	Plus3 domain-containing protein. (605 aa)
	C3ZT22_BRAFL	Uncharacterized protein. (240 aa)
	C3ZTY0_BRAFL	Uncharacterized protein. (154 aa)
	C3ZTZ3_BRAFL	ARS2 domain-containing protein. (478 aa)
	C3Z9A7_BRAFL	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (137 aa)
	C3XVR5_BRAFL	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (384 aa)
	C3XVS6_BRAFL	eRF1_1 domain-containing protein. (452 aa)
	C3XWD2_BRAFL	PCM1_C domain-containing protein. (1969 aa)
	C3XYF0_BRAFL	RNB domain-containing protein; Belongs to the RNR ribonuclease family. (813 aa)
	C3Y0B2_BRAFL	Uncharacterized protein. (243 aa)
	C3Y1F0_BRAFL	Uncharacterized protein. (1006 aa)
	C3Y1F6_BRAFL	Uncharacterized protein. (323 aa)
	C3Y529_BRAFL	TPR_REGION domain-containing protein. (1183 aa)
	C3YCP5_BRAFL	Uncharacterized protein. (1057 aa)
	C3YDR2_BRAFL	YL1_C domain-containing protein. (310 aa)
	C3YFD7_BRAFL	Uncharacterized protein; Belongs to the MT-A70-like family. (568 aa)
	C3YFU8_BRAFL	Uncharacterized protein; Belongs to the MT-A70-like family. (164 aa)
	C3YIR8_BRAFL	Uncharacterized protein. (297 aa)
	C3YM01_BRAFL	Uncharacterized protein. (566 aa)
	C3YNI7_BRAFL	Uncharacterized protein. (1175 aa)
	MED15	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (757 aa)
	C3YYA8_BRAFL	Uncharacterized protein. (245 aa)
	C3YYB2_BRAFL	Uncharacterized protein. (243 aa)
	C3YYB3_BRAFL	Uncharacterized protein. (243 aa)
	C3YYB5_BRAFL	Uncharacterized protein. (312 aa)
	C3YZ01_BRAFL	DNA ligase. (793 aa)
	C4A0E9_BRAFL	Uncharacterized protein. (157 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3Y1F0_BRAFL	C3YNI7_BRAFL	C3Y1F0	C3YNI7	Uncharacterized protein.	Uncharacterized protein.	0.575
C3Y529_BRAFL	C3ZG24_BRAFL	C3Y529	C3ZG24	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.999
C3Y529_BRAFL	C3ZQG2_BRAFL	C3Y529	C3ZQG2	TPR_REGION domain-containing protein.	Plus3 domain-containing protein.	0.999
C3YCP5_BRAFL	C3ZQG2_BRAFL	C3YCP5	C3ZQG2	Uncharacterized protein.	Plus3 domain-containing protein.	0.439
C3YDR2_BRAFL	C3ZG24_BRAFL	C3YDR2	C3ZG24	YL1_C domain-containing protein.	Uncharacterized protein.	0.424
C3YFD7_BRAFL	C3YFU8_BRAFL	C3YFD7	C3YFU8	Uncharacterized protein; Belongs to the MT-A70-like family.	Uncharacterized protein; Belongs to the MT-A70-like family.	0.998
C3YFU8_BRAFL	C3YFD7_BRAFL	C3YFU8	C3YFD7	Uncharacterized protein; Belongs to the MT-A70-like family.	Uncharacterized protein; Belongs to the MT-A70-like family.	0.998
C3YM01_BRAFL	C3YNI7_BRAFL	C3YM01	C3YNI7	Uncharacterized protein.	Uncharacterized protein.	0.975
C3YNI7_BRAFL	C3Y1F0_BRAFL	C3YNI7	C3Y1F0	Uncharacterized protein.	Uncharacterized protein.	0.575
C3YNI7_BRAFL	C3YM01_BRAFL	C3YNI7	C3YM01	Uncharacterized protein.	Uncharacterized protein.	0.975
C3YNI7_BRAFL	C3YZ01_BRAFL	C3YNI7	C3YZ01	Uncharacterized protein.	DNA ligase.	0.595
C3YZ01_BRAFL	C3YNI7_BRAFL	C3YZ01	C3YNI7	DNA ligase.	Uncharacterized protein.	0.595
C3Z9A7_BRAFL	C3ZF42_BRAFL	C3Z9A7	C3ZF42	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.999
C3Z9A7_BRAFL	C3ZTY0_BRAFL	C3Z9A7	C3ZTY0	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.969
C3Z9A7_BRAFL	C4A0E9_BRAFL	C3Z9A7	C4A0E9	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.969
C3Z9A7_BRAFL	MED15	C3Z9A7	C3YXZ1	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.973
C3ZF42_BRAFL	C3Z9A7_BRAFL	C3ZF42	C3Z9A7	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.999
C3ZF42_BRAFL	C3ZTY0_BRAFL	C3ZF42	C3ZTY0	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.982
C3ZF42_BRAFL	C4A0E9_BRAFL	C3ZF42	C4A0E9	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.982
C3ZF42_BRAFL	MED15	C3ZF42	C3YXZ1	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.993