(85 nodes) Regulation of I-kappaB kinase/NF-kappaB signaling network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3Z502_BRAFL	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (434 aa)
	C3XPY9_BRAFL	Protein kinase domain-containing protein. (347 aa)
	C3XQI1_BRAFL	Uncharacterized protein. (180 aa)
	C3XU27_BRAFL	Uncharacterized protein. (1078 aa)
	C3XU40_BRAFL	Uncharacterized protein. (2155 aa)
	C3XVI4_BRAFL	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (214 aa)
	C3XVY8_BRAFL	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (414 aa)
	C3XW52_BRAFL	Uncharacterized protein. (734 aa)
	C3XXF8_BRAFL	Uncharacterized protein. (554 aa)
	C3XZ56_BRAFL	PPM-type phosphatase domain-containing protein. (382 aa)
	C3XZR9_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa)
	C3XZX1_BRAFL	Uncharacterized protein. (655 aa)
	C3Y0R3_BRAFL	Uncharacterized protein. (532 aa)
	C3Y276_BRAFL	Uncharacterized protein. (902 aa)
	C3Y3E3_BRAFL	ZU5 domain-containing protein. (731 aa)
	C3Y3U7_BRAFL	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	C3Y5B1_BRAFL	Uncharacterized protein. (987 aa)
	C3Y7A9_BRAFL	Protein kinase domain-containing protein. (739 aa)
	C3Y7F3_BRAFL	Protein kinase domain-containing protein. (702 aa)
	C3Y9I1_BRAFL	JmjC domain-containing protein. (210 aa)
	C3YD32_BRAFL	MATH domain-containing protein. (219 aa)
	C3YD33_BRAFL	Uncharacterized protein. (208 aa)
	C3YDJ4_BRAFL	RING-type domain-containing protein. (299 aa)
	C3YDV1_BRAFL	Protein kinase domain-containing protein. (1102 aa)
	C3YE67_BRAFL	Uncharacterized protein; Belongs to the tumor necrosis factor family. (180 aa)
	C3YEQ1_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (476 aa)
	C3YFF1_BRAFL	Uncharacterized protein. (733 aa)
	C3YFT5_BRAFL	Protein kinase domain-containing protein. (755 aa)
	C3YIP4_BRAFL	Uncharacterized protein. (688 aa)
	C3YIU7_BRAFL	Uncharacterized protein. (1125 aa)
	C3YJ81_BRAFL	Uncharacterized protein. (645 aa)
	C3YKX2_BRAFL	Deacetylase sirtuin-type domain-containing protein. (312 aa)
	C3YLZ3_BRAFL	Uncharacterized protein. (262 aa)
	C3YN38_BRAFL	Uncharacterized protein. (252 aa)
	C3YPE7_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (447 aa)
	C3YQ63_BRAFL	OTU domain-containing protein. (647 aa)
	C3YTG3_BRAFL	Uncharacterized protein. (408 aa)
	C3YUP9_BRAFL	Protein kinase domain-containing protein. (925 aa)
	C3YV25_BRAFL	Uncharacterized protein. (498 aa)
	C3YWJ6_BRAFL	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (96 aa)
	C3YXD5_BRAFL	OTU domain-containing protein. (226 aa)
	C3YXE8_BRAFL	OTU domain-containing protein. (845 aa)
	C3Z126_BRAFL	Ubiquitin carboxyl-terminal hydrolase. (402 aa)
	C3Z1H5_BRAFL	SEFIR domain-containing protein. (163 aa)
	C3Z1H6_BRAFL	SEFIR domain-containing protein. (238 aa)
	C3Z4P8_BRAFL	Uncharacterized protein. (195 aa)
	C3Z5H8_BRAFL	CC2-LZ domain-containing protein. (231 aa)
	C3Z5J9_BRAFL	CC2-LZ domain-containing protein. (694 aa)
	C3Z6H1_BRAFL	Uncharacterized protein. (491 aa)
	C3Z6H2_BRAFL	NR LBD domain-containing protein. (121 aa)
	C3Z6H4_BRAFL	Uncharacterized protein. (320 aa)
	C3Z8L5_BRAFL	Uncharacterized protein. (559 aa)
	C3Z9W3_BRAFL	Cactin_mid domain-containing protein. (207 aa)
	C3ZCS1_BRAFL	Uncharacterized protein. (716 aa)
	C3ZDW2_BRAFL	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (374 aa)
	C3ZDW4_BRAFL	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (288 aa)
	C3ZDW6_BRAFL	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (412 aa)
	C3ZE87_BRAFL	Protein kinase domain-containing protein. (659 aa)
	C3ZG31_BRAFL	Uncharacterized protein. (474 aa)
	C3ZG34_BRAFL	Uncharacterized protein. (552 aa)
	C3ZG35_BRAFL	Uncharacterized protein. (658 aa)
	C3ZG37_BRAFL	Uncharacterized protein. (631 aa)
	C3ZG38_BRAFL	MATH domain-containing protein. (373 aa)
	C3ZG39_BRAFL	Uncharacterized protein. (549 aa)
	C3ZG40_BRAFL	Uncharacterized protein. (503 aa)
	C3ZG42_BRAFL	Uncharacterized protein. (482 aa)
	C3ZGY7_BRAFL	Uncharacterized protein. (298 aa)
	C3ZH58_BRAFL	Protein kinase domain-containing protein. (1633 aa)
	C3ZHV2_BRAFL	Uncharacterized protein. (403 aa)
	C3ZIA7_BRAFL	Helicase C-terminal domain-containing protein. (118 aa)
	C3ZIP6_BRAFL	Uncharacterized protein. (673 aa)
	C3ZNE1_BRAFL	ZU5 domain-containing protein. (397 aa)
	C3ZNP8_BRAFL	Protein kinase domain-containing protein. (634 aa)
	C3ZP99_BRAFL	Death domain-containing protein. (195 aa)
	C3ZPZ7_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (451 aa)
	C3ZQU2_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (739 aa)
	C3ZSQ6_BRAFL	RIO domain-containing protein. (470 aa)
	C3ZXG1_BRAFL	Uncharacterized protein. (122 aa)
	C3ZXZ8_BRAFL	Death domain-containing protein. (298 aa)
	C3ZYN0_BRAFL	Uncharacterized protein. (1246 aa)
	C3ZYU6_BRAFL	OTU domain-containing protein. (909 aa)
	C3ZYU7_BRAFL	MATH domain-containing protein. (107 aa)
	C3ZYU8_BRAFL	Uncharacterized protein. (1550 aa)
	C3ZYU9_BRAFL	OTU domain-containing protein. (264 aa)
	C3ZZM6_BRAFL	Uncharacterized protein. (197 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XPY9_BRAFL	C3XVY8_BRAFL	C3XPY9	C3XVY8	Protein kinase domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.971
C3XPY9_BRAFL	C3XXF8_BRAFL	C3XPY9	C3XXF8	Protein kinase domain-containing protein.	Uncharacterized protein.	0.754
C3XPY9_BRAFL	C3YKX2_BRAFL	C3XPY9	C3YKX2	Protein kinase domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.538
C3XPY9_BRAFL	C3Z502_BRAFL	C3XPY9	C3Z502	Protein kinase domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.997
C3XQI1_BRAFL	C3ZNP8_BRAFL	C3XQI1	C3ZNP8	Uncharacterized protein.	Protein kinase domain-containing protein.	0.544
C3XU40_BRAFL	C3Y7A9_BRAFL	C3XU40	C3Y7A9	Uncharacterized protein.	Protein kinase domain-containing protein.	0.872
C3XU40_BRAFL	C3YFT5_BRAFL	C3XU40	C3YFT5	Uncharacterized protein.	Protein kinase domain-containing protein.	0.608
C3XU40_BRAFL	C3YQ63_BRAFL	C3XU40	C3YQ63	Uncharacterized protein.	OTU domain-containing protein.	0.425
C3XU40_BRAFL	C3YV25_BRAFL	C3XU40	C3YV25	Uncharacterized protein.	Uncharacterized protein.	0.999
C3XU40_BRAFL	C3YXD5_BRAFL	C3XU40	C3YXD5	Uncharacterized protein.	OTU domain-containing protein.	0.448
C3XU40_BRAFL	C3YXE8_BRAFL	C3XU40	C3YXE8	Uncharacterized protein.	OTU domain-containing protein.	0.448
C3XU40_BRAFL	C3ZE87_BRAFL	C3XU40	C3ZE87	Uncharacterized protein.	Protein kinase domain-containing protein.	0.872
C3XU40_BRAFL	C3ZNP8_BRAFL	C3XU40	C3ZNP8	Uncharacterized protein.	Protein kinase domain-containing protein.	0.498
C3XU40_BRAFL	C3ZXG1_BRAFL	C3XU40	C3ZXG1	Uncharacterized protein.	Uncharacterized protein.	0.608
C3XU40_BRAFL	C3ZYN0_BRAFL	C3XU40	C3ZYN0	Uncharacterized protein.	Uncharacterized protein.	0.448
C3XU40_BRAFL	C3ZYU6_BRAFL	C3XU40	C3ZYU6	Uncharacterized protein.	OTU domain-containing protein.	0.448
C3XU40_BRAFL	C3ZYU8_BRAFL	C3XU40	C3ZYU8	Uncharacterized protein.	Uncharacterized protein.	0.448
C3XU40_BRAFL	C3ZYU9_BRAFL	C3XU40	C3ZYU9	Uncharacterized protein.	OTU domain-containing protein.	0.448
C3XVY8_BRAFL	C3XPY9_BRAFL	C3XVY8	C3XPY9	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Protein kinase domain-containing protein.	0.971
C3XVY8_BRAFL	C3XXF8_BRAFL	C3XVY8	C3XXF8	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein.	0.803