(75 nodes) Mitotic cell cycle phase transition network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3ZH71_BRAFL	TOG domain-containing protein. (228 aa)
	C3ZJB9_BRAFL	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (74 aa)
	C3ZJT7_BRAFL	Serine/threonine-protein kinase PLK. (575 aa)
	C3ZLG5_BRAFL	Protein kinase domain-containing protein. (898 aa)
	C3ZLP9_BRAFL	TPR_REGION domain-containing protein. (575 aa)
	C3ZNJ6_BRAFL	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	C3ZR37_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (306 aa)
	C3ZSX0_BRAFL	CYCLIN domain-containing protein; Belongs to the cyclin family. (317 aa)
	C3ZSX1_BRAFL	CYCLIN domain-containing protein; Belongs to the cyclin family. (344 aa)
	C3ZV28_BRAFL	Uncharacterized protein. (383 aa)
	C3ZWB1_BRAFL	Uncharacterized protein. (465 aa)
	C3ZWB2_BRAFL	Uncharacterized protein. (588 aa)
	C3ZZX8_BRAFL	Uncharacterized protein. (285 aa)
	C3ZYP1_BRAFL	TRASH domain-containing protein. (154 aa)
	C3XPP3_BRAFL	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (136 aa)
	C3XQE9_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (305 aa)
	C3XS09_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
	C3XYZ6_BRAFL	BUB1 N-terminal domain-containing protein. (234 aa)
	C3XZS2_BRAFL	Uncharacterized protein. (652 aa)
	C3Y0B4_BRAFL	Uncharacterized protein. (180 aa)
	C3Y0L2_BRAFL	APC1_C domain-containing protein. (2078 aa)
	C3Y0Z0_BRAFL	Uncharacterized protein. (645 aa)
	C3Y135_BRAFL	Protein kinase domain-containing protein. (239 aa)
	C3Y235_BRAFL	BHLH domain-containing protein. (369 aa)
	C3Y264_BRAFL	Uncharacterized protein. (162 aa)
	C3Y4P7_BRAFL	Zpr1 domain-containing protein. (262 aa)
	C3Y5M5_BRAFL	Protein kinase domain-containing protein. (595 aa)
	C3Y5U4_BRAFL	Uncharacterized protein. (1422 aa)
	C3Y6A6_BRAFL	Fork-head domain-containing protein. (84 aa)
	C3Y7D6_BRAFL	JmjC domain-containing protein. (404 aa)
	C3Y7V1_BRAFL	Uncharacterized protein. (305 aa)
	C3Y7W6_BRAFL	Uncharacterized protein. (219 aa)
	C3Y909_BRAFL	Deacetylase sirtuin-type domain-containing protein. (399 aa)
	C3YA46_BRAFL	F-box domain-containing protein. (427 aa)
	C3YBP7_BRAFL	BRCT domain-containing protein. (531 aa)
	C3YCQ9_BRAFL	Uncharacterized protein. (545 aa)
	C3YEF4_BRAFL	USP domain-containing protein. (195 aa)
	C3YEF5_BRAFL	USP domain-containing protein. (148 aa)
	C3YEG7_BRAFL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
	C3YEL6_BRAFL	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (579 aa)
	C3YEL7_BRAFL	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (540 aa)
	C3YHH3_BRAFL	Uncharacterized protein. (283 aa)
	C3YIL0_BRAFL	Uncharacterized protein. (943 aa)
	C3YJ59_BRAFL	CYCLIN domain-containing protein; Belongs to the cyclin family. (208 aa)
	C3YK31_BRAFL	Uncharacterized protein. (537 aa)
	C3YM20_BRAFL	F-box domain-containing protein. (421 aa)
	C3YNN9_BRAFL	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (82 aa)
	C3YRS7_BRAFL	Uncharacterized protein. (466 aa)
	C3YT44_BRAFL	Uncharacterized protein. (373 aa)
	C3YTV7_BRAFL	CULLIN_2 domain-containing protein; Belongs to the cullin family. (818 aa)
	C3YVP4_BRAFL	Uncharacterized protein. (894 aa)
	C3YWA3_BRAFL	Ubiquitin-like domain-containing protein. (367 aa)
	C3YYK3_BRAFL	TPR_REGION domain-containing protein. (854 aa)
	C3YYL5_BRAFL	Cupin_8 domain-containing protein. (357 aa)
	C3YYZ3_BRAFL	Cyclin_C domain-containing protein. (189 aa)
	C3YZV0_BRAFL	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (320 aa)
	C3Z216_BRAFL	Uncharacterized protein. (487 aa)
	C3Z217_BRAFL	PDZ domain-containing protein. (254 aa)
	C3Z446_BRAFL	PPM-type phosphatase domain-containing protein. (317 aa)
	C3Z514_BRAFL	JmjC domain-containing protein. (409 aa)
	C3Z548_BRAFL	F-box domain-containing protein. (645 aa)
	C3Z6I2_BRAFL	Uncharacterized protein. (227 aa)
	UBE2S_BRAFL	Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (213 aa)
	C3Z7N7_BRAFL	F-box domain-containing protein; Belongs to the cyclin family. (784 aa)
	C3Z8A2_BRAFL	RB_A domain-containing protein. (305 aa)
	C3Z917_BRAFL	Protein kinase domain-containing protein. (450 aa)
	C3Z9I8_BRAFL	Protein kinase domain-containing protein. (201 aa)
	C3ZB62_BRAFL	B box-type domain-containing protein. (603 aa)
	C3ZBD4_BRAFL	F-box domain-containing protein. (333 aa)
	C3ZBU1_BRAFL	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (412 aa)
	C3ZCK6_BRAFL	JmjC domain-containing protein. (452 aa)
	C3ZDV8_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
	C3ZE12_BRAFL	Cyclin N-terminal domain-containing protein. (242 aa)
	C3ZFF7_BRAFL	Uncharacterized protein. (392 aa)
	C3ZG26_BRAFL	Serine/threonine-protein phosphatase. (304 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XQE9_BRAFL	C3XS09_BRAFL	C3XQE9	C3XS09	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.741
C3XQE9_BRAFL	C3XYZ6_BRAFL	C3XQE9	C3XYZ6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BUB1 N-terminal domain-containing protein.	0.727
C3XQE9_BRAFL	C3Y0L2_BRAFL	C3XQE9	C3Y0L2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	APC1_C domain-containing protein.	0.840
C3XQE9_BRAFL	C3Y5M5_BRAFL	C3XQE9	C3Y5M5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.412
C3XQE9_BRAFL	C3Y6A6_BRAFL	C3XQE9	C3Y6A6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.638
C3XQE9_BRAFL	C3YCQ9_BRAFL	C3XQE9	C3YCQ9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.513
C3XQE9_BRAFL	C3YEG7_BRAFL	C3XQE9	C3YEG7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.799
C3XQE9_BRAFL	C3YEL6_BRAFL	C3XQE9	C3YEL6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.562
C3XQE9_BRAFL	C3YEL7_BRAFL	C3XQE9	C3YEL7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.562
C3XQE9_BRAFL	C3YJ59_BRAFL	C3XQE9	C3YJ59	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.783
C3XQE9_BRAFL	C3YK31_BRAFL	C3XQE9	C3YK31	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.813
C3XQE9_BRAFL	C3YM20_BRAFL	C3XQE9	C3YM20	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	F-box domain-containing protein.	0.856
C3XQE9_BRAFL	C3YNN9_BRAFL	C3XQE9	C3YNN9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.848
C3XQE9_BRAFL	C3YTV7_BRAFL	C3XQE9	C3YTV7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.598
C3XQE9_BRAFL	C3YYK3_BRAFL	C3XQE9	C3YYK3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	TPR_REGION domain-containing protein.	0.818
C3XQE9_BRAFL	C3YYZ3_BRAFL	C3XQE9	C3YYZ3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin_C domain-containing protein.	0.761
C3XQE9_BRAFL	C3YZV0_BRAFL	C3XQE9	C3YZV0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.982
C3XQE9_BRAFL	C3Z7N7_BRAFL	C3XQE9	C3Z7N7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	F-box domain-containing protein; Belongs to the cyclin family.	0.783
C3XQE9_BRAFL	C3Z8A2_BRAFL	C3XQE9	C3Z8A2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RB_A domain-containing protein.	0.775
C3XQE9_BRAFL	C3ZBU1_BRAFL	C3XQE9	C3ZBU1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.970