(34 nodes) Regulation of myeloid cell differentiation network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3ZMX3_BRAFL	Homeobox domain-containing protein. (489 aa)
	C3XYF1_BRAFL	Uncharacterized protein. (305 aa)
	C3Y235_BRAFL	BHLH domain-containing protein. (369 aa)
	C3Y529_BRAFL	TPR_REGION domain-containing protein. (1183 aa)
	C3Y8G6_BRAFL	Death domain-containing protein. (1064 aa)
	C3Y8K8_BRAFL	Uncharacterized protein. (299 aa)
	C3Y9Y5_BRAFL	Fe2OG dioxygenase domain-containing protein. (405 aa)
	C3YCY1_BRAFL	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (370 aa)
	C3YEQ1_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (476 aa)
	C3YFM2_BRAFL	Uncharacterized protein. (1230 aa)
	C3YW57_BRAFL	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (504 aa)
	C3Z4P8_BRAFL	Uncharacterized protein. (195 aa)
	C3Z8A2_BRAFL	RB_A domain-containing protein. (305 aa)
	C3Z946_BRAFL	Uncharacterized protein. (310 aa)
	C3ZA33_BRAFL	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (347 aa)
	C3ZCS2_BRAFL	PITH domain-containing protein. (206 aa)
	C3ZFY9_BRAFL	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (277 aa)
	C3ZFZ1_BRAFL	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (399 aa)
	C3ZG24_BRAFL	Uncharacterized protein. (536 aa)
	C3ZGI8_BRAFL	Uncharacterized protein; Belongs to the heat shock protein 70 family. (692 aa)
	C3ZGI9_BRAFL	Uncharacterized protein. (106 aa)
	C3ZH92_BRAFL	Uncharacterized protein. (414 aa)
	C3ZLL3_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1049 aa)
	C3ZLL7_BRAFL	DUF3385 domain-containing protein. (1400 aa)
	C3ZQU2_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (739 aa)
	C3ZRT7_BRAFL	Uncharacterized protein. (389 aa)
	C3ZRT8_BRAFL	SAP domain-containing protein. (159 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
	C3ZV77_BRAFL	Ras-GAP domain-containing protein. (1311 aa)
	C3ZV81_BRAFL	CRAL-TRIO domain-containing protein. (1389 aa)
	C3ZV92_BRAFL	DUF1279 domain-containing protein. (121 aa)
	C3ZXZ8_BRAFL	Death domain-containing protein. (298 aa)
	C3ZZM6_BRAFL	Uncharacterized protein. (197 aa)
	C4A0W8_BRAFL	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (504 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3Y529_BRAFL	C3ZG24_BRAFL	C3Y529	C3ZG24	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.999
C3Y8G6_BRAFL	C3YEQ1_BRAFL	C3Y8G6	C3YEQ1	Death domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.884
C3Y8G6_BRAFL	C3Z4P8_BRAFL	C3Y8G6	C3Z4P8	Death domain-containing protein.	Uncharacterized protein.	0.960
C3Y8G6_BRAFL	C3Z946_BRAFL	C3Y8G6	C3Z946	Death domain-containing protein.	Uncharacterized protein.	0.884
C3Y8G6_BRAFL	C3ZQU2_BRAFL	C3Y8G6	C3ZQU2	Death domain-containing protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.884
C3Y8G6_BRAFL	C3ZXZ8_BRAFL	C3Y8G6	C3ZXZ8	Death domain-containing protein.	Death domain-containing protein.	0.960
C3Y8G6_BRAFL	C3ZZM6_BRAFL	C3Y8G6	C3ZZM6	Death domain-containing protein.	Uncharacterized protein.	0.960
C3YEQ1_BRAFL	C3Y8G6_BRAFL	C3YEQ1	C3Y8G6	Uncharacterized protein; Belongs to the peptidase C14A family.	Death domain-containing protein.	0.884
C3YEQ1_BRAFL	C3Z4P8_BRAFL	C3YEQ1	C3Z4P8	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.751
C3YEQ1_BRAFL	C3ZXZ8_BRAFL	C3YEQ1	C3ZXZ8	Uncharacterized protein; Belongs to the peptidase C14A family.	Death domain-containing protein.	0.751
C3YEQ1_BRAFL	C3ZZM6_BRAFL	C3YEQ1	C3ZZM6	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.751
C3YW57_BRAFL	C4A0W8_BRAFL	C3YW57	C4A0W8	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.543
C3YW57_BRAFL	EIF6	C3YW57	C3ZUA7	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	0.890
C3Z4P8_BRAFL	C3Y8G6_BRAFL	C3Z4P8	C3Y8G6	Uncharacterized protein.	Death domain-containing protein.	0.960
C3Z4P8_BRAFL	C3YEQ1_BRAFL	C3Z4P8	C3YEQ1	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.751
C3Z4P8_BRAFL	C3Z946_BRAFL	C3Z4P8	C3Z946	Uncharacterized protein.	Uncharacterized protein.	0.707
C3Z4P8_BRAFL	C3ZQU2_BRAFL	C3Z4P8	C3ZQU2	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.751
C3Z4P8_BRAFL	C3ZXZ8_BRAFL	C3Z4P8	C3ZXZ8	Uncharacterized protein.	Death domain-containing protein.	0.540
C3Z4P8_BRAFL	C3ZZM6_BRAFL	C3Z4P8	C3ZZM6	Uncharacterized protein.	Uncharacterized protein.	0.544
C3Z946_BRAFL	C3Y8G6_BRAFL	C3Z946	C3Y8G6	Uncharacterized protein.	Death domain-containing protein.	0.884