(111 nodes) Negative regulation of mitotic cell cycle network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3Z8A2_BRAFL	RB_A domain-containing protein. (305 aa)
	C4A079_BRAFL	R3H domain-containing protein. (58 aa)
	C3ZXT7_BRAFL	Uncharacterized protein. (572 aa)
	C3ZXK7_BRAFL	Uncharacterized protein. (1911 aa)
	C3ZXH5_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (439 aa)
	C3ZXH2_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (340 aa)
	C3ZV28_BRAFL	Uncharacterized protein. (383 aa)
	C3ZT37_BRAFL	Uncharacterized protein. (858 aa)
	C3ZR83_BRAFL	Uncharacterized protein. (459 aa)
	C3ZQQ4_BRAFL	Uncharacterized protein. (197 aa)
	C3ZQJ9_BRAFL	Uncharacterized protein. (707 aa)
	C3ZQ46_BRAFL	NDK domain-containing protein; Belongs to the NDK family. (172 aa)
	C3ZMY3_BRAFL	Uncharacterized protein. (516 aa)
	C3ZLG5_BRAFL	Protein kinase domain-containing protein. (898 aa)
	C3ZJT7_BRAFL	Serine/threonine-protein kinase PLK. (575 aa)
	C3ZI04_BRAFL	Uncharacterized protein. (577 aa)
	C3ZHN8_BRAFL	G-patch domain-containing protein. (364 aa)
	C3ZHI0_BRAFL	Helicase ATP-binding domain-containing protein. (504 aa)
	C3ZG24_BRAFL	Uncharacterized protein. (536 aa)
	C3ZFR4_BRAFL	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (1032 aa)
	C3ZEP2_BRAFL	Uncharacterized protein. (344 aa)
	C3ZEN4_BRAFL	Mre11_DNA_bind domain-containing protein. (441 aa)
	C3ZDV8_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (313 aa)
	C3ZBQ9_BRAFL	Helicase ATP-binding domain-containing protein. (270 aa)
	C3ZA80_BRAFL	Uncharacterized protein. (1140 aa)
	C3Z9F1_BRAFL	MACPF domain-containing protein. (697 aa)
	C3Z6W7_BRAFL	ERCC4 domain-containing protein. (598 aa)
	C3Z6I4_BRAFL	Uncharacterized protein. (107 aa)
	C3Z5Z2_BRAFL	HORMA domain-containing protein. (204 aa)
	C3Z4C0_BRAFL	Protein kinase domain-containing protein. (934 aa)
	C3Z2N3_BRAFL	Uncharacterized protein. (621 aa)
	C3Z2J8_BRAFL	Fork-head domain-containing protein. (191 aa)
	C3Z291_BRAFL	RING-type domain-containing protein. (668 aa)
	C3Z1H4_BRAFL	Uncharacterized protein. (1738 aa)
	C3Z1H3_BRAFL	Uncharacterized protein. (270 aa)
	C3Z1B4_BRAFL	Uncharacterized protein. (206 aa)
	C3YZM5_BRAFL	Uncharacterized protein. (453 aa)
	C3YYS3_BRAFL	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (598 aa)
	C3YYP1_BRAFL	FCP1 homology domain-containing protein. (258 aa)
	C3YYJ5_BRAFL	Uncharacterized protein. (492 aa)
	C3YYE5_BRAFL	SH3 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (606 aa)
	C3YX67_BRAFL	Headcase domain-containing protein. (175 aa)
	C3YWT5_BRAFL	C2H2-type domain-containing protein. (540 aa)
	C3YW39_BRAFL	Uncharacterized protein. (2614 aa)
	C3YV86_BRAFL	Uncharacterized protein. (269 aa)
	C3YUU6_BRAFL	Uncharacterized protein. (232 aa)
	C3YTI8_BRAFL	Uncharacterized protein. (247 aa)
	C3YT07_BRAFL	Uncharacterized protein. (302 aa)
	C3YPG2_BRAFL	Uncharacterized protein. (188 aa)
	C3YNI7_BRAFL	Uncharacterized protein. (1175 aa)
	C3YMW6_BRAFL	Uncharacterized protein. (1065 aa)
	C3YMM2_BRAFL	Anti_prolifrtn domain-containing protein. (105 aa)
	C3YM60_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	C3YKR1_BRAFL	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (666 aa)
	C3YJQ0_BRAFL	MPN domain-containing protein. (268 aa)
	C3YJD7_BRAFL	Uncharacterized protein. (719 aa)
	C3YJ81_BRAFL	Uncharacterized protein. (645 aa)
	C3YIF0_BRAFL	Uncharacterized protein. (721 aa)
	C3YHB0_BRAFL	Uncharacterized protein. (681 aa)
	C3YH73_BRAFL	FAT domain-containing protein. (2357 aa)
	C3YH71_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (553 aa)
	C3YFG1_BRAFL	FHA domain-containing protein. (721 aa)
	C3YFD4_BRAFL	Uncharacterized protein. (489 aa)
	C3YF65_BRAFL	Uncharacterized protein. (488 aa)
	C3YF64_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4388 aa)
	C3YF62_BRAFL	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (311 aa)
	C3YE70_BRAFL	Death domain-containing protein. (89 aa)
	C3YDL0_BRAFL	Uncharacterized protein. (638 aa)
	C3YAZ4_BRAFL	CARD domain-containing protein. (324 aa)
	C3YAV9_BRAFL	Uncharacterized protein. (377 aa)
	C3YAB8_BRAFL	GTSE1_N domain-containing protein. (779 aa)
	C3Y9K6_BRAFL	Uncharacterized protein. (846 aa)
	C3Y9A2_BRAFL	Fibronectin type-III domain-containing protein. (441 aa)
	C3Y8U9_BRAFL	Uncharacterized protein. (418 aa)
	C3Y8U7_BRAFL	Uncharacterized protein. (430 aa)
	C3Y8N4_BRAFL	Helicase C-terminal domain-containing protein. (591 aa)
	C3Y7Z7_BRAFL	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	C3Y7M2_BRAFL	Uncharacterized protein; Belongs to the peptidase C19 family. (1318 aa)
	C3Y6Z8_BRAFL	Uncharacterized protein. (972 aa)
	C3Y6Y9_BRAFL	Uncharacterized protein. (861 aa)
	C3Y6J8_BRAFL	Uncharacterized protein. (156 aa)
	C3Y5S4_BRAFL	Uncharacterized protein. (334 aa)
	C3Y4U9_BRAFL	Uncharacterized protein. (120 aa)
	C3Y254_BRAFL	PWWP domain-containing protein. (437 aa)
	C3Y1F9_BRAFL	Uncharacterized protein. (1907 aa)
	C3Y120_BRAFL	Uncharacterized protein. (82 aa)
	C3Y0Z2_BRAFL	Uncharacterized protein. (386 aa)
	C3Y0V9_BRAFL	Uncharacterized protein. (343 aa)
	C3Y0V8_BRAFL	ERCC4 domain-containing protein. (600 aa)
	C3Y0V4_BRAFL	ERCC4 domain-containing protein. (268 aa)
	C3Y0G6_BRAFL	RING-type domain-containing protein. (906 aa)
	C3Y089_BRAFL	WD_REPEATS_REGION domain-containing protein. (626 aa)
	C3XYZ6_BRAFL	BUB1 N-terminal domain-containing protein. (234 aa)
	C3XYZ5_BRAFL	Protein kinase domain-containing protein. (211 aa)
	C3XVS4_BRAFL	WD_REPEATS_REGION domain-containing protein. (187 aa)
	C3XVS3_BRAFL	WD_REPEATS_REGION domain-containing protein. (200 aa)
	C3XVR3_BRAFL	WD_REPEATS_REGION domain-containing protein. (187 aa)
	C3XVR2_BRAFL	WD_REPEATS_REGION domain-containing protein. (353 aa)
	C3XVP9_BRAFL	Uncharacterized protein. (312 aa)
	C3XU15_BRAFL	Uncharacterized protein. (1053 aa)
	C3XTY8_BRAFL	Uncharacterized protein. (581 aa)
	C3XTK2_BRAFL	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (905 aa)
	C3XT78_BRAFL	Uncharacterized protein. (458 aa)
	C3XS09_BRAFL	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
	C3XRW7_BRAFL	Uncharacterized protein. (1231 aa)
	C3XRW4_BRAFL	Uncharacterized protein. (496 aa)
	C3XRL6_BRAFL	Uncharacterized protein. (299 aa)
	C3XQC2_BRAFL	PI31_Prot_N domain-containing protein. (636 aa)
	C3XPU5_BRAFL	ERCC4 domain-containing protein. (1825 aa)
	C3XPS9_BRAFL	Uncharacterized protein; Belongs to the peptidase C14A family. (309 aa)
	BABAM2	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (383 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BABAM2	C3XRL6_BRAFL	B6NXD5	C3XRL6	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.543
BABAM2	C3YFG1_BRAFL	B6NXD5	C3YFG1	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	FHA domain-containing protein.	0.475
BABAM2	C3YH71_BRAFL	B6NXD5	C3YH71	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.460
BABAM2	C3YH73_BRAFL	B6NXD5	C3YH73	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	FAT domain-containing protein.	0.460
BABAM2	C3YJQ0_BRAFL	B6NXD5	C3YJQ0	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	MPN domain-containing protein.	0.986
BABAM2	C3YT07_BRAFL	B6NXD5	C3YT07	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YTI8_BRAFL	B6NXD5	C3YTI8	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YW39_BRAFL	B6NXD5	C3YW39	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.897
BABAM2	C3ZEN4_BRAFL	B6NXD5	C3ZEN4	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Mre11_DNA_bind domain-containing protein.	0.469
BABAM2	C3ZV28_BRAFL	B6NXD5	C3ZV28	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.495
C3XPS9_BRAFL	C3YJ81_BRAFL	C3XPS9	C3YJ81	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.541
C3XPS9_BRAFL	C3YPG2_BRAFL	C3XPS9	C3YPG2	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.504
C3XPS9_BRAFL	C3ZQQ4_BRAFL	C3XPS9	C3ZQQ4	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.504
C3XPU5_BRAFL	C3Y0V4_BRAFL	C3XPU5	C3Y0V4	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.540
C3XPU5_BRAFL	C3Y0V8_BRAFL	C3XPU5	C3Y0V8	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.540
C3XPU5_BRAFL	C3Y0V9_BRAFL	C3XPU5	C3Y0V9	ERCC4 domain-containing protein.	Uncharacterized protein.	0.540
C3XPU5_BRAFL	C3YFG1_BRAFL	C3XPU5	C3YFG1	ERCC4 domain-containing protein.	FHA domain-containing protein.	0.443
C3XPU5_BRAFL	C3YH71_BRAFL	C3XPU5	C3YH71	ERCC4 domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.402
C3XPU5_BRAFL	C3YH73_BRAFL	C3XPU5	C3YH73	ERCC4 domain-containing protein.	FAT domain-containing protein.	0.402
C3XPU5_BRAFL	C3YNI7_BRAFL	C3XPU5	C3YNI7	ERCC4 domain-containing protein.	Uncharacterized protein.	0.509