(38 nodes) Positive regulation of epithelial cell proliferation network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3Y991_BRAFL	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (321 aa)
	C3YXE8_BRAFL	OTU domain-containing protein. (845 aa)
	C3YXD5_BRAFL	OTU domain-containing protein. (226 aa)
	C3YW57_BRAFL	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (504 aa)
	C3YTM1_BRAFL	Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (207 aa)
	C3YSF6_BRAFL	Uncharacterized protein. (2447 aa)
	C3YQP4_BRAFL	BZIP domain-containing protein; Belongs to the bZIP family. (321 aa)
	C3YPI7_BRAFL	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (305 aa)
	C3YKX2_BRAFL	Deacetylase sirtuin-type domain-containing protein. (312 aa)
	C3YJB3_BRAFL	WD_REPEATS_REGION domain-containing protein. (595 aa)
	C3YGX1_BRAFL	H2.0-like homeobox. (389 aa)
	C3YZC7_BRAFL	Uncharacterized protein. (164 aa)
	C3Y235_BRAFL	BHLH domain-containing protein. (369 aa)
	C3Y212_BRAFL	Deacetylase sirtuin-type domain-containing protein. (414 aa)
	C3Y1Z3_BRAFL	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	C3XWJ2_BRAFL	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (252 aa)
	C3XW39_BRAFL	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (163 aa)
	Thop1.1	BZIP domain-containing protein. (336 aa)
	C3XVR6_BRAFL	BZIP domain-containing protein. (242 aa)
	C3XT85_BRAFL	Uncharacterized protein. (78 aa)
	C4A0W8_BRAFL	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (504 aa)
	C3ZYU9_BRAFL	OTU domain-containing protein. (264 aa)
	C3ZYU8_BRAFL	Uncharacterized protein. (1550 aa)
	C3ZYU6_BRAFL	OTU domain-containing protein. (909 aa)
	C3ZYN0_BRAFL	Uncharacterized protein. (1246 aa)
	C3ZXL0_BRAFL	Protein kinase domain-containing protein. (96 aa)
	C3ZXK9_BRAFL	Uncharacterized protein. (246 aa)
	C3ZV81_BRAFL	CRAL-TRIO domain-containing protein. (1389 aa)
	C3ZV77_BRAFL	Ras-GAP domain-containing protein. (1311 aa)
	C3ZTW1_BRAFL	Smoothend-like protein protein; Belongs to the G-protein coupled receptor Fz/Smo family. (1250 aa)
	C3ZSP0_BRAFL	BZIP domain-containing protein. (404 aa)
	C3ZQP6_BRAFL	Peptidase M12B domain-containing protein. (99 aa)
	C3ZQP5_BRAFL	Disintegrin domain-containing protein. (277 aa)
	C3ZGC1_BRAFL	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa)
	C3Z937_BRAFL	Uncharacterized protein. (111 aa)
	C3Z3V6_BRAFL	TGF_BETA_2 domain-containing protein. (411 aa)
	C3Z1D3_BRAFL	Uncharacterized protein. (2265 aa)
	C3YZU1_BRAFL	Uncharacterized protein. (500 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XW39_BRAFL	C3Z3V6_BRAFL	C3XW39	C3Z3V6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	TGF_BETA_2 domain-containing protein.	0.431
C3Y212_BRAFL	C3YKX2_BRAFL	C3Y212	C3YKX2	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.686
C3Y212_BRAFL	C3YQP4_BRAFL	C3Y212	C3YQP4	Deacetylase sirtuin-type domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.403
C3Y235_BRAFL	C3YQP4_BRAFL	C3Y235	C3YQP4	BHLH domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.494
C3YJB3_BRAFL	C3YKX2_BRAFL	C3YJB3	C3YKX2	WD_REPEATS_REGION domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.402
C3YKX2_BRAFL	C3Y212_BRAFL	C3YKX2	C3Y212	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.686
C3YKX2_BRAFL	C3YJB3_BRAFL	C3YKX2	C3YJB3	Deacetylase sirtuin-type domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.402
C3YKX2_BRAFL	C3YQP4_BRAFL	C3YKX2	C3YQP4	Deacetylase sirtuin-type domain-containing protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.642
C3YQP4_BRAFL	C3Y212_BRAFL	C3YQP4	C3Y212	BZIP domain-containing protein; Belongs to the bZIP family.	Deacetylase sirtuin-type domain-containing protein.	0.403
C3YQP4_BRAFL	C3Y235_BRAFL	C3YQP4	C3Y235	BZIP domain-containing protein; Belongs to the bZIP family.	BHLH domain-containing protein.	0.494
C3YQP4_BRAFL	C3YKX2_BRAFL	C3YQP4	C3YKX2	BZIP domain-containing protein; Belongs to the bZIP family.	Deacetylase sirtuin-type domain-containing protein.	0.642
C3YW57_BRAFL	C4A0W8_BRAFL	C3YW57	C4A0W8	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.543
C3Z3V6_BRAFL	C3XW39_BRAFL	C3Z3V6	C3XW39	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.431
C3ZV77_BRAFL	C3ZV81_BRAFL	C3ZV77	C3ZV81	Ras-GAP domain-containing protein.	CRAL-TRIO domain-containing protein.	0.951
C3ZV81_BRAFL	C3ZV77_BRAFL	C3ZV81	C3ZV77	CRAL-TRIO domain-containing protein.	Ras-GAP domain-containing protein.	0.951
C4A0W8_BRAFL	C3YW57_BRAFL	C4A0W8	C3YW57	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.543