(36 nodes) Metalloprotease DUBs network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	C3Z761_BRAFL	Histone H2A; Belongs to the histone H2A family. (124 aa)
	MYSM1	Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (809 aa)
	BABAM2	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (383 aa)
	C3XRL6_BRAFL	Uncharacterized protein. (299 aa)
	C3XXY6_BRAFL	MPN domain-containing protein. (311 aa)
	C3XZV4_BRAFL	Histone H2A; Belongs to the histone H2A family. (135 aa)
	C3XZW8_BRAFL	MPN domain-containing protein. (393 aa)
	C3Y2C9_BRAFL	Uncharacterized protein. (609 aa)
	C3Y495_BRAFL	MPN domain-containing protein. (404 aa)
	C3Y4F4_BRAFL	Uncharacterized protein. (676 aa)
	C3YJQ0_BRAFL	MPN domain-containing protein. (268 aa)
	C3YMB5_BRAFL	Histone H2A; Belongs to the histone H2A family. (120 aa)
	C3YMG8_BRAFL	Histone H2A; Belongs to the histone H2A family. (124 aa)
	C3YT07_BRAFL	Uncharacterized protein. (302 aa)
	C3YTI8_BRAFL	Uncharacterized protein. (247 aa)
	C3YW39_BRAFL	Uncharacterized protein. (2614 aa)
	C3YWP1_BRAFL	Histone H2A; Belongs to the histone H2A family. (135 aa)
	C3YZR5_BRAFL	Uncharacterized protein. (600 aa)
	C3Z0B1_BRAFL	MPN domain-containing protein. (432 aa)
	C3Z2G8_BRAFL	Uncharacterized protein. (164 aa)
	C3Z6T6_BRAFL	Histone H2A; Belongs to the histone H2A family. (88 aa)
	C3Z781_BRAFL	Histone H2A; Belongs to the histone H2A family. (122 aa)
	C3Z788_BRAFL	Histone H2A; Belongs to the histone H2A family. (125 aa)
	C3Z797_BRAFL	Histone H2A; Belongs to the histone H2A family. (125 aa)
	C3Z7A2_BRAFL	Histone H2A; Belongs to the histone H2A family. (57 aa)
	C3Z7D8_BRAFL	Histone H2A; Belongs to the histone H2A family. (125 aa)
	C3Z880_BRAFL	Histone H2A; Belongs to the histone H2A family. (124 aa)
	C3Z8I8_BRAFL	Histone H2A; Belongs to the histone H2A family. (141 aa)
	C3ZJ99_BRAFL	SWIRM domain-containing protein. (105 aa)
	C3ZNL5_BRAFL	Histone H2A; Belongs to the histone H2A family. (124 aa)
	C3ZSC9_BRAFL	Uncharacterized protein. (97 aa)
	C3ZVL0_BRAFL	Uncharacterized protein. (105 aa)
	C3ZYL9_BRAFL	Histone H2A; Belongs to the histone H2A family. (124 aa)
	C3ZYM2_BRAFL	Histone H2A; Belongs to the histone H2A family. (124 aa)
	C3ZYM5_BRAFL	Histone H2A; Belongs to the histone H2A family. (61 aa)
	C3ZYM7_BRAFL	Histone H2A; Belongs to the histone H2A family. (83 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BABAM2	C3XRL6_BRAFL	B6NXD5	C3XRL6	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.543
BABAM2	C3Y495_BRAFL	B6NXD5	C3Y495	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	MPN domain-containing protein.	0.970
BABAM2	C3Y4F4_BRAFL	B6NXD5	C3Y4F4	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.869
BABAM2	C3YJQ0_BRAFL	B6NXD5	C3YJQ0	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	MPN domain-containing protein.	0.986
BABAM2	C3YT07_BRAFL	B6NXD5	C3YT07	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YTI8_BRAFL	B6NXD5	C3YTI8	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.963
BABAM2	C3YW39_BRAFL	B6NXD5	C3YW39	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.897
BABAM2	C3Z2G8_BRAFL	B6NXD5	C3Z2G8	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.971
BABAM2	C3ZSC9_BRAFL	B6NXD5	C3ZSC9	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.775
BABAM2	C3ZVL0_BRAFL	B6NXD5	C3ZVL0	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	Uncharacterized protein.	0.775
C3XRL6_BRAFL	BABAM2	C3XRL6	B6NXD5	Uncharacterized protein.	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...]	0.543
C3XRL6_BRAFL	C3Y495_BRAFL	C3XRL6	C3Y495	Uncharacterized protein.	MPN domain-containing protein.	0.970
C3XRL6_BRAFL	C3Y4F4_BRAFL	C3XRL6	C3Y4F4	Uncharacterized protein.	Uncharacterized protein.	0.869
C3XRL6_BRAFL	C3YJQ0_BRAFL	C3XRL6	C3YJQ0	Uncharacterized protein.	MPN domain-containing protein.	0.986
C3XRL6_BRAFL	C3YT07_BRAFL	C3XRL6	C3YT07	Uncharacterized protein.	Uncharacterized protein.	0.963
C3XRL6_BRAFL	C3YTI8_BRAFL	C3XRL6	C3YTI8	Uncharacterized protein.	Uncharacterized protein.	0.963
C3XRL6_BRAFL	C3YW39_BRAFL	C3XRL6	C3YW39	Uncharacterized protein.	Uncharacterized protein.	0.897
C3XRL6_BRAFL	C3Z2G8_BRAFL	C3XRL6	C3Z2G8	Uncharacterized protein.	Uncharacterized protein.	0.971
C3XRL6_BRAFL	C3ZSC9_BRAFL	C3XRL6	C3ZSC9	Uncharacterized protein.	Uncharacterized protein.	0.775
C3XRL6_BRAFL	C3ZVL0_BRAFL	C3XRL6	C3ZVL0	Uncharacterized protein.	Uncharacterized protein.	0.775