(180 nodes) Sensory Perception network (Branchiostoma floridae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C3YYY9_BRAFL	Uncharacterized protein. (526 aa)
	C3YZW3_BRAFL	WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family. (438 aa)
	C3YZX2_BRAFL	SSD domain-containing protein. (341 aa)
	C3YZX5_BRAFL	SSD domain-containing protein. (855 aa)
	C3YZX6_BRAFL	SSD domain-containing protein. (836 aa)
	C3YZX8_BRAFL	SSD domain-containing protein. (952 aa)
	C3Z052_BRAFL	Uncharacterized protein. (1806 aa)
	C3Z0N7_BRAFL	Uncharacterized protein. (168 aa)
	C3Z0Q6_BRAFL	SSD domain-containing protein. (845 aa)
	C3Z0Z5_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (271 aa)
	C3Z1J4_BRAFL	Uncharacterized protein. (253 aa)
	C3Z1M4_BRAFL	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (329 aa)
	C3Z2H5_BRAFL	Uncharacterized protein. (291 aa)
	C3Z2M8_BRAFL	Uncharacterized protein. (149 aa)
	C3Z2N0_BRAFL	Uncharacterized protein. (99 aa)
	C3Z2N1_BRAFL	Uncharacterized protein. (140 aa)
	C3Z356_BRAFL	Uncharacterized protein. (481 aa)
	C3Z3E4_BRAFL	Amino_oxidase domain-containing protein. (582 aa)
	C3Z3E6_BRAFL	Uncharacterized protein. (581 aa)
	C3Z4M3_BRAFL	Uncharacterized protein. (735 aa)
	C3Z4P6_BRAFL	ANK_REP_REGION domain-containing protein. (928 aa)
	C3Z634_BRAFL	Uncharacterized protein. (1217 aa)
	C3Z699_BRAFL	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (950 aa)
	C3Z6A5_BRAFL	Uncharacterized protein. (897 aa)
	C3Z7H8_BRAFL	N-acetyltransferase domain-containing protein. (244 aa)
	C3Z7R9_BRAFL	Uncharacterized protein. (618 aa)
	C3Z807_BRAFL	Uncharacterized protein. (789 aa)
	C3Z808_BRAFL	TMC domain-containing protein. (833 aa)
	C3Z8B2_BRAFL	Guanylate cyclase. (493 aa)
	C3Z8S8_BRAFL	Uncharacterized protein. (207 aa)
	C3Z8V7_BRAFL	IPT/TIG domain-containing protein. (387 aa)
	C3ZC40_BRAFL	Uncharacterized protein; Belongs to the cytochrome P450 family. (429 aa)
	C3ZCN7_BRAFL	TMC domain-containing protein. (539 aa)
	C3ZCP0_BRAFL	TMC domain-containing protein. (651 aa)
	C3ZD32_BRAFL	Uncharacterized protein. (184 aa)
	C3ZEA9_BRAFL	SSD domain-containing protein. (1017 aa)
	C3ZEH9_BRAFL	Uncharacterized protein. (52 aa)
	C3ZEQ0_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
	C3ZEQ1_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
	C3ZEQ2_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (227 aa)
	C3ZEQ5_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
	C3ZEX6_BRAFL	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (361 aa)
	C3ZER0_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
	C3ZEQ9_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (233 aa)
	C3ZIS6_BRAFL	Uncharacterized protein. (254 aa)
	C3ZIN0_BRAFL	Lipase domain-containing protein. (78 aa)
	C3ZHI9_BRAFL	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (142 aa)
	C3ZH27_BRAFL	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (433 aa)
	C3ZGC3_BRAFL	Uncharacterized protein. (772 aa)
	C3ZFP1_BRAFL	zf-3CxxC domain-containing protein. (241 aa)
	C3ZFP0_BRAFL	zf-3CxxC domain-containing protein. (285 aa)
	C3ZFN9_BRAFL	Uncharacterized protein. (350 aa)
	C3ZFK2_BRAFL	Uncharacterized protein. (1607 aa)
	C3ZFD2_BRAFL	Laminin EGF-like domain-containing protein. (185 aa)
	C3ZFD1_BRAFL	Laminin EGF-like domain-containing protein. (178 aa)
	C3ZFD0_BRAFL	Laminin EGF-like domain-containing protein. (394 aa)
	C3ZFC9_BRAFL	Laminin EGF-like domain-containing protein. (183 aa)
	C3ZF59_BRAFL	Peptidase_M24 domain-containing protein. (234 aa)
	C3ZF58_BRAFL	Uncharacterized protein. (491 aa)
	C3ZF57_BRAFL	Creatinase_N domain-containing protein. (257 aa)
	C3ZF56_BRAFL	Peptidase_M24 domain-containing protein. (208 aa)
	C3ZF54_BRAFL	Creatinase_N domain-containing protein. (173 aa)
	C3ZF53_BRAFL	Peptidase_M24 domain-containing protein. (286 aa)
	C3ZF22_BRAFL	Uncharacterized protein. (990 aa)
	C3ZEX9_BRAFL	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (480 aa)
	C3ZEX7_BRAFL	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (208 aa)
	C4A118_BRAFL	Uncharacterized protein. (694 aa)
	C4A117_BRAFL	Uncharacterized protein. (670 aa)
	C3ZZZ9_BRAFL	Uncharacterized protein. (207 aa)
	C3ZZZ8_BRAFL	Uncharacterized protein. (74 aa)
	C3ZZM8_BRAFL	ANK_REP_REGION domain-containing protein. (885 aa)
	C3ZZJ0_BRAFL	Uncharacterized protein. (176 aa)
	C3ZYI6_BRAFL	Uncharacterized protein. (369 aa)
	C3ZXZ5_BRAFL	SAM_3 domain-containing protein. (61 aa)
	C3ZXZ4_BRAFL	PTB domain-containing protein. (370 aa)
	C3ZXN7_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (288 aa)
	C3ZWT7_BRAFL	Uncharacterized protein. (92 aa)
	C3ZWT6_BRAFL	PDZ domain-containing protein. (90 aa)
	C3ZWP9_BRAFL	Uncharacterized protein. (662 aa)
	C3ZWP8_BRAFL	Uncharacterized protein. (577 aa)
	C3ZWI6_BRAFL	Uncharacterized protein. (1854 aa)
	C3ZVN8_BRAFL	Gasdermin domain-containing protein. (458 aa)
	C3ZU95_BRAFL	SSD domain-containing protein. (706 aa)
	C3ZU88_BRAFL	SSD domain-containing protein. (752 aa)
	C3ZTV3_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
	C3ZSN8_BRAFL	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (1558 aa)
	C3ZRW1_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (220 aa)
	C3ZQX1_BRAFL	Uncharacterized protein. (1501 aa)
	C3ZQW9_BRAFL	SSD domain-containing protein. (950 aa)
	C3ZNS7_BRAFL	SSD domain-containing protein. (936 aa)
	C3Y143_BRAFL	Vezatin domain-containing protein. (808 aa)
	C3ZKN1_BRAFL	SSD domain-containing protein. (843 aa)
	C3ZJ95_BRAFL	SSD domain-containing protein. (871 aa)
	C3ZJ94_BRAFL	Uncharacterized protein. (200 aa)
	C3ZJ93_BRAFL	Uncharacterized protein. (956 aa)
	C3ZJ91_BRAFL	Vitellogenin domain-containing protein. (1042 aa)
	C3ZJ90_BRAFL	Vitellogenin domain-containing protein. (800 aa)
	C3ZJ15_BRAFL	Uncharacterized protein. (3569 aa)
	C3XQ32_BRAFL	Uncharacterized protein. (1813 aa)
	C3XQ33_BRAFL	NtA domain-containing protein. (197 aa)
	C3XQ89_BRAFL	zf-3CxxC domain-containing protein. (195 aa)
	C3XQB0_BRAFL	Uncharacterized protein. (1875 aa)
	C3XQS7_BRAFL	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (503 aa)
	C3XS00_BRAFL	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (401 aa)
	C3XS42_BRAFL	SSD domain-containing protein. (734 aa)
	C3XS43_BRAFL	SSD domain-containing protein. (851 aa)
	C3XSS8_BRAFL	SSD domain-containing protein. (600 aa)
	C3XU16_BRAFL	Vitellogenin domain-containing protein. (1571 aa)
	C3XU55_BRAFL	Uncharacterized protein. (821 aa)
	C3XV06_BRAFL	Uncharacterized protein. (1546 aa)
	C3XV88_BRAFL	Uncharacterized protein. (1277 aa)
	C3XWA6_BRAFL	Uncharacterized protein. (230 aa)
	C3XWD6_BRAFL	Serine/threonine-protein phosphatase. (635 aa)
	C3XYJ2_BRAFL	Uncharacterized protein. (502 aa)
	C3XYJ3_BRAFL	Uncharacterized protein. (518 aa)
	C3XYJ4_BRAFL	Uncharacterized protein. (533 aa)
	C3XZ59_BRAFL	Uncharacterized protein. (3145 aa)
	C3XZD9_BRAFL	N-acetyltransferase domain-containing protein. (176 aa)
	C3XZH0_BRAFL	Uncharacterized protein. (112 aa)
	C3XZY6_BRAFL	Uncharacterized protein. (3154 aa)
	C3Y0P9_BRAFL	Uncharacterized protein. (538 aa)
	C3Y0S7_BRAFL	SSD domain-containing protein. (814 aa)
	C3Y0T2_BRAFL	SSD domain-containing protein. (918 aa)
	C3ZMU4_BRAFL	Uncharacterized protein. (1174 aa)
	C3Y145_BRAFL	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (187 aa)
	C3Y4A4_BRAFL	DEP domain-containing protein. (588 aa)
	C3Y6K9_BRAFL	Amino_oxidase domain-containing protein. (876 aa)
	C3Y7F4_BRAFL	Uncharacterized protein. (596 aa)
	C3Y7I7_BRAFL	G_PROTEIN_RECEP_F1_2 domain-containing protein. (319 aa)
	C3YB47_BRAFL	Uncharacterized protein. (1291 aa)
	C3YBJ7_BRAFL	C2 domain-containing protein. (444 aa)
	C3YBJ8_BRAFL	Uncharacterized protein. (1535 aa)
	C3YBP8_BRAFL	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (419 aa)
	C3YBQ7_BRAFL	SSD domain-containing protein. (507 aa)
	C3YBQ8_BRAFL	SSD domain-containing protein. (334 aa)
	C3YBS2_BRAFL	Uncharacterized protein. (892 aa)
	C3YCG9_BRAFL	SSD domain-containing protein. (664 aa)
	C3YCH2_BRAFL	SSD domain-containing protein. (840 aa)
	C3YCU7_BRAFL	Uncharacterized protein. (549 aa)
	C3YD62_BRAFL	Uncharacterized protein. (506 aa)
	RdhD	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
	C3YDT8_BRAFL	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa)
	C3YDT9_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (333 aa)
	C3YFV1_BRAFL	Uncharacterized protein. (1252 aa)
	C3YG10_BRAFL	PTB domain-containing protein. (662 aa)
	C3YGR9_BRAFL	PH domain-containing protein. (154 aa)
	C3YH15_BRAFL	Uncharacterized protein. (662 aa)
	C3YHE5_BRAFL	Uncharacterized protein. (558 aa)
	C3YI13_BRAFL	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)
	C3YI16_BRAFL	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (327 aa)
	C3YIA6_BRAFL	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
	C3YK82_BRAFL	G_PROTEIN_RECEP_F1_2 domain-containing protein. (377 aa)
	C3YKJ2_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa)
	C3YKJ3_BRAFL	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (299 aa)
	C3YLE3_BRAFL	Lipase domain-containing protein. (72 aa)
	C3YLE6_BRAFL	Uncharacterized protein. (502 aa)
	C3YLE8_BRAFL	Lipase domain-containing protein. (83 aa)
	C3YN13_BRAFL	Uncharacterized protein. (655 aa)
	C3YN16_BRAFL	Ig-like domain-containing protein. (85 aa)
	C3YP05_BRAFL	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (385 aa)
	C3YPF1_BRAFL	SSD domain-containing protein. (743 aa)
	C3YPR4_BRAFL	C2 domain-containing protein. (85 aa)
	C3YPY0_BRAFL	Uncharacterized protein. (702 aa)
	C3YQ92_BRAFL	WD_REPEATS_REGION domain-containing protein. (247 aa)
	C3YQA4_BRAFL	WD_REPEATS_REGION domain-containing protein. (355 aa)
	C3YQV9_BRAFL	Uncharacterized protein. (531 aa)
	C3YQW6_BRAFL	Uncharacterized protein. (564 aa)
	C3YSJ6_BRAFL	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (485 aa)
	C3YSN4_BRAFL	Uncharacterized protein. (190 aa)
	C3YTA8_BRAFL	SSD domain-containing protein. (1200 aa)
	C3YUD0_BRAFL	Cyclic nucleotide-binding domain-containing protein. (302 aa)
	C3YUE4_BRAFL	Uncharacterized protein. (564 aa)
	C3YVG5_BRAFL	Uncharacterized protein. (128 aa)
	C3YVH5_BRAFL	Uncharacterized protein. (1824 aa)
	C3YVT4_BRAFL	Retinol dehydrogenase, retinaldehyde reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (328 aa)
	C3YVZ8_BRAFL	Uncharacterized protein. (58 aa)
	C3YXR5_BRAFL	GST N-terminal domain-containing protein. (239 aa)
	C3YYS8_BRAFL	Uncharacterized protein. (1189 aa)
	C3YYT3_BRAFL	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1870 aa)
	C3YYU4_BRAFL	Uncharacterized protein. (1401 aa)

Your Current Organism:

Branchiostoma floridae

NCBI taxonomy Id: 7739
Other names: Amphioxus floridae, B. floridae, Florida lancelet

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3XQB0_BRAFL	C3XZY6_BRAFL	C3XQB0	C3XZY6	Uncharacterized protein.	Uncharacterized protein.	0.580
C3XQB0_BRAFL	C3Z2M8_BRAFL	C3XQB0	C3Z2M8	Uncharacterized protein.	Uncharacterized protein.	0.505
C3XQB0_BRAFL	C3Z2N0_BRAFL	C3XQB0	C3Z2N0	Uncharacterized protein.	Uncharacterized protein.	0.471
C3XQB0_BRAFL	C3Z2N1_BRAFL	C3XQB0	C3Z2N1	Uncharacterized protein.	Uncharacterized protein.	0.505
C3XQB0_BRAFL	C3Z4M3_BRAFL	C3XQB0	C3Z4M3	Uncharacterized protein.	Uncharacterized protein.	0.580
C3XQB0_BRAFL	C3Z634_BRAFL	C3XQB0	C3Z634	Uncharacterized protein.	Uncharacterized protein.	0.580
C3XQB0_BRAFL	C3ZWI6_BRAFL	C3XQB0	C3ZWI6	Uncharacterized protein.	Uncharacterized protein.	0.580
C3XQS7_BRAFL	C3YP05_BRAFL	C3XQS7	C3YP05	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.912
C3XQS7_BRAFL	C3YSJ6_BRAFL	C3XQS7	C3YSJ6	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.473
C3XQS7_BRAFL	C3ZF22_BRAFL	C3XQS7	C3ZF22	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Uncharacterized protein.	0.440
C3XQS7_BRAFL	C3ZF53_BRAFL	C3XQS7	C3ZF53	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Peptidase_M24 domain-containing protein.	0.440
C3XQS7_BRAFL	C3ZF54_BRAFL	C3XQS7	C3ZF54	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Creatinase_N domain-containing protein.	0.440
C3XQS7_BRAFL	C3ZF56_BRAFL	C3XQS7	C3ZF56	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Peptidase_M24 domain-containing protein.	0.440
C3XQS7_BRAFL	C3ZF57_BRAFL	C3XQS7	C3ZF57	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Creatinase_N domain-containing protein.	0.440
C3XQS7_BRAFL	C3ZF58_BRAFL	C3XQS7	C3ZF58	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Uncharacterized protein.	0.440
C3XQS7_BRAFL	C3ZF59_BRAFL	C3XQS7	C3ZF59	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Peptidase_M24 domain-containing protein.	0.440
C3XWA6_BRAFL	C3YXR5_BRAFL	C3XWA6	C3YXR5	Uncharacterized protein.	GST N-terminal domain-containing protein.	0.544
C3XWA6_BRAFL	C3YYT3_BRAFL	C3XWA6	C3YYT3	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.483
C3XWA6_BRAFL	C3Z699_BRAFL	C3XWA6	C3Z699	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.460
C3XWA6_BRAFL	C3Z6A5_BRAFL	C3XWA6	C3Z6A5	Uncharacterized protein.	Uncharacterized protein.	0.555