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S4RX26_PETMA S4RX26_PETMA S4R496_PETMA S4R496_PETMA S4R4E8_PETMA S4R4E8_PETMA S4R4F4_PETMA S4R4F4_PETMA S4R4I6_PETMA S4R4I6_PETMA S4R4P9_PETMA S4R4P9_PETMA S4R4U7_PETMA S4R4U7_PETMA KDELR1 KDELR1 S4R5N3_PETMA S4R5N3_PETMA S4R682_PETMA S4R682_PETMA STON2 STON2 S4R7G3_PETMA S4R7G3_PETMA KDELR1-2 KDELR1-2 COPG1 COPG1 S4R7Y9_PETMA S4R7Y9_PETMA S4R837_PETMA S4R837_PETMA PGAP1 PGAP1 S4RA77_PETMA S4RA77_PETMA S4RB54_PETMA S4RB54_PETMA S4RBB2_PETMA S4RBB2_PETMA S4RBG4_PETMA S4RBG4_PETMA S4RCC0_PETMA S4RCC0_PETMA AP3B2 AP3B2 S4RCJ6_PETMA S4RCJ6_PETMA S4RD39_PETMA S4RD39_PETMA S4RD63_PETMA S4RD63_PETMA S4REJ1_PETMA S4REJ1_PETMA S4RET8_PETMA S4RET8_PETMA S4RF09_PETMA S4RF09_PETMA S4RF21_PETMA S4RF21_PETMA S4RFF1_PETMA S4RFF1_PETMA S4RFG4_PETMA S4RFG4_PETMA S4RGM6_PETMA S4RGM6_PETMA S4RHC0_PETMA S4RHC0_PETMA S4RID1_PETMA S4RID1_PETMA ENY2 ENY2 S4RIT6_PETMA S4RIT6_PETMA S4RIV8_PETMA S4RIV8_PETMA S4RKT0_PETMA S4RKT0_PETMA S4RMB2_PETMA S4RMB2_PETMA S4RN16_PETMA S4RN16_PETMA S4RN59_PETMA S4RN59_PETMA S4RN75_PETMA S4RN75_PETMA S4RNR7_PETMA S4RNR7_PETMA S4RPT7_PETMA S4RPT7_PETMA S4RQ18_PETMA S4RQ18_PETMA S4RSQ2_PETMA S4RSQ2_PETMA S4RSZ8_PETMA S4RSZ8_PETMA SEC24C SEC24C S4RUY0_PETMA S4RUY0_PETMA S4RVA5_PETMA S4RVA5_PETMA S4RVM4_PETMA S4RVM4_PETMA S4RVP3_PETMA S4RVP3_PETMA S4RWS8_PETMA S4RWS8_PETMA S4RX74_PETMA S4RX74_PETMA S4RXC1_PETMA S4RXC1_PETMA S4RXD5_PETMA S4RXD5_PETMA S4RXF3_PETMA S4RXF3_PETMA S4RXG5_PETMA S4RXG5_PETMA S4RXU4_PETMA S4RXU4_PETMA S4RXY1_PETMA S4RXY1_PETMA S4RY45_PETMA S4RY45_PETMA STON2-2 STON2-2 S4RYB0_PETMA S4RYB0_PETMA S4RZB9_PETMA S4RZB9_PETMA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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S4RX26_PETMAMitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (175 aa)
S4R496_PETMAAdaptin_N domain-containing protein. (516 aa)
S4R4E8_PETMACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (465 aa)
S4R4F4_PETMAAP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (423 aa)
S4R4I6_PETMAUncharacterized protein. (779 aa)
S4R4P9_PETMAVacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (793 aa)
S4R4U7_PETMASorting nexin; Involved in several stages of intracellular trafficking. (405 aa)
KDELR1ER lumen protein-retaining receptor. (212 aa)
S4R5N3_PETMASEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (210 aa)
S4R682_PETMACoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (963 aa)
STON2Stonin 2; Belongs to the adaptor complexes medium subunit family. (536 aa)
S4R7G3_PETMAAP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (450 aa)
KDELR1-2ER lumen protein-retaining receptor. (212 aa)
COPG1Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (899 aa)
S4R7Y9_PETMAProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
S4R837_PETMAPlug_translocon domain-containing protein. (473 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (923 aa)
S4RA77_PETMAAP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (946 aa)
S4RB54_PETMASEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (163 aa)
S4RBB2_PETMAGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (176 aa)
S4RBG4_PETMANuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (252 aa)
S4RCC0_PETMASEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (112 aa)
AP3B2AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1074 aa)
S4RCJ6_PETMAVacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
S4RD39_PETMAAdaptor related protein complex 3 subunit delta 1. (1230 aa)
S4RD63_PETMANuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (805 aa)
S4REJ1_PETMAVPS37C subunit of ESCRT-I. (325 aa)
S4RET8_PETMAAdaptor related protein complex 1 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (275 aa)
S4RF09_PETMACoatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (183 aa)
S4RF21_PETMAAdaptin_N domain-containing protein. (187 aa)
S4RFF1_PETMASecretion associated, Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (201 aa)
S4RFG4_PETMAAP complex subunit beta. (955 aa)
S4RGM6_PETMAMitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (283 aa)
S4RHC0_PETMAAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
S4RID1_PETMATranslocase of inner mitochondrial membrane 10 homolog (yeast). (87 aa)
ENY2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex [...] (104 aa)
S4RIT6_PETMAVacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (848 aa)
S4RIV8_PETMAMHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (290 aa)
S4RKT0_PETMAVesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. (160 aa)
S4RMB2_PETMAGolgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
S4RN16_PETMAVacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
S4RN59_PETMATranslocase of inner mitochondrial membrane 9 homolog. (90 aa)
S4RN75_PETMAExocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (708 aa)
S4RNR7_PETMAUncharacterized protein. (362 aa)
S4RPT7_PETMANuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (666 aa)
S4RQ18_PETMANucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (325 aa)
S4RSQ2_PETMAAdaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (512 aa)
S4RSZ8_PETMACoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (936 aa)
SEC24CSEC24 homolog C, COPII coat complex component. (1092 aa)
S4RUY0_PETMAAP complex subunit beta; Belongs to the adaptor complexes large subunit family. (640 aa)
S4RVA5_PETMAProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (294 aa)
S4RVM4_PETMATarget of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family. (357 aa)
S4RVP3_PETMASorting nexin; Involved in several stages of intracellular trafficking. (413 aa)
S4RWS8_PETMAUncharacterized protein. (776 aa)
S4RX74_PETMASorting nexin; Involved in several stages of intracellular trafficking. (406 aa)
S4RXC1_PETMAVacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (937 aa)
S4RXD5_PETMAImportin subunit alpha; Belongs to the importin alpha family. (524 aa)
S4RXF3_PETMAProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1326 aa)
S4RXG5_PETMAAdaptor related protein complex 3 subunit sigma 2. (192 aa)
S4RXU4_PETMAExocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (300 aa)
S4RXY1_PETMACoatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (172 aa)
S4RY45_PETMAAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
STON2-2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (572 aa)
S4RYB0_PETMAImportin subunit alpha; Belongs to the importin alpha family. (504 aa)
S4RZB9_PETMAUbiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (599 aa)
Your Current Organism:
Petromyzon marinus
NCBI taxonomy Id: 7757
Other names: P. marinus, marine lamprey, sea lamprey, sea lampreys
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