STRINGSTRING
Xaut_0076 Xaut_0076 dut dut Xaut_0078 Xaut_0078 Xaut_0080 Xaut_0080 Xaut_0148 Xaut_0148 Xaut_0480 Xaut_0480 bioB bioB Xaut_1181 Xaut_1181 Xaut_1182 Xaut_1182 nadA nadA Xaut_1184 Xaut_1184 panB panB folE folE coaE coaE Xaut_1843 Xaut_1843 Xaut_2037 Xaut_2037 ribA ribA coaA coaA panD panD Xaut_2492 Xaut_2492 Xaut_2493 Xaut_2493 Xaut_2918 Xaut_2918 bioD bioD Xaut_2920 Xaut_2920 mutM mutM Xaut_3529 Xaut_3529 coaD coaD Xaut_3804 Xaut_3804 Xaut_3933 Xaut_3933 Xaut_3934 Xaut_3934 ribB ribB nrdR nrdR Xaut_4278 Xaut_4278 Xaut_4279 Xaut_4279 ribH ribH nusB nusB thiL thiL panC panC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Xaut_0076TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074; KEGG: rru:Rru_A3795 transcriptional regulator, BadM/Rrf2 family. (146 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (158 aa)
Xaut_0078Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa)
Xaut_0080PFAM: transposase IS4 family protein; KEGG: sil:SPO0489 ISSpo2, transposase. (451 aa)
Xaut_0148TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; KEGG: rpb:RPB_1056 ModD protein; Belongs to the NadC/ModD family. (280 aa)
Xaut_0480TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE domain protein; KEGG: reh:H16_B1719 ketopantoate reductase. (346 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (345 aa)
Xaut_1181TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; KEGG: mes:Meso_2555 nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (283 aa)
Xaut_1182L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (513 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (347 aa)
Xaut_1184KEGG: bra:BRADO4532 conserved hypothetical protein; putative nicotinic acid mononucleotide (NMN) biosynthesis protein. (324 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (280 aa)
folEPFAM: GTP cyclohydrolase I; KEGG: bra:BRADO2984 GTP cyclohydrolase I. (242 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
Xaut_1843TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase; KEGG: nha:Nham_3161 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (316 aa)
Xaut_2037PFAM: bifunctional deaminase-reductase domain protein; KEGG: csa:Csal_1173 bifunctional deaminase-reductase-like protein. (282 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (370 aa)
coaATIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: rpc:RPC_0312 pantothenate kinase. (323 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (150 aa)
Xaut_2492TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: mlo:mll0786 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (163 aa)
Xaut_2493PFAM: dihydropteroate synthase DHPS; KEGG: cdf:CD1450 dihydropteroate synthase. (146 aa)
Xaut_29188-amino-7-oxononanoate synthase; PFAM: Orn/Lys/Arg decarboxylase major region; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: rpa:RPA2972 8-amino-7-oxononanoate synthase. (387 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa)
Xaut_2920TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: rpb:RPB_4342 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (293 aa)
Xaut_3529Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (145 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
Xaut_38048-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: neu:NE1388 aminotransferase class-I. (444 aa)
Xaut_3933L-aspartate oxidase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: reu:Reut_B4589 L-aspartate oxidase. (544 aa)
Xaut_3934PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: reu:Reut_B4590 ferredoxin:4Fe-4S ferredoxin, iron-sulfur binding. (220 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (437 aa)
nrdRATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (182 aa)
Xaut_4278Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (383 aa)
Xaut_4279TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: ret:RHE_CH01511 riboflavin synthase, alpha chain protein. (203 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (165 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (163 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (336 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa)
Your Current Organism:
Xanthobacter autotrophicus
NCBI taxonomy Id: 78245
Other names: X. autotrophicus Py2, Xanthobacter autotrophicus Py2, Xanthobacter autotrophicus str. Py2, Xanthobacter autotrophicus strain Py2, Xanthobacter sp. Py2
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