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lpxC lpxC Xaut_1257 Xaut_1257 lpxK lpxK Xaut_1482 Xaut_1482 Xaut_1895 Xaut_1895 Xaut_1953 Xaut_1953 kdsB kdsB Xaut_3770 Xaut_3770 Xaut_3771 Xaut_3771 hldD hldD hldE hldE kdsA kdsA Xaut_4426 Xaut_4426 Xaut_4428 Xaut_4428 lpxD lpxD Xaut_4735 Xaut_4735
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxCUDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (311 aa)
Xaut_1257PFAM: lipid A biosynthesis acyltransferase; KEGG: nwi:Nwi_1242 lipid A biosynthesis lauroyl acyltransferase. (308 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (343 aa)
Xaut_1482Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (431 aa)
Xaut_1895TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS); KEGG: bra:BRADO6245 arabinose 5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. (338 aa)
Xaut_1953Hydrolase, HAD-superfamily, subfamily IIIA; TIGRFAM: histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rpe:RPE_1450 histidinol-phosphate phosphatase family protein. (185 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (255 aa)
Xaut_3770TIGRFAM: lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; KEGG: aeh:Mlg_2792 lipopolysaccharide heptosyltransferase II. (351 aa)
Xaut_3771TIGRFAM: lipopolysaccharide heptosyltransferase I; PFAM: glycosyl transferase family 9; KEGG: eba:ebA3997 heptosyltransferase I. (335 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (336 aa)
hldErfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (482 aa)
kdsATIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: rpc:RPC_2477 2-dehydro-3-deoxyphosphooctonate aldolase. (292 aa)
Xaut_4426lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (397 aa)
Xaut_4428acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (268 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (365 aa)
Xaut_4735PFAM: glycosyl transferase family 9; KEGG: tbd:Tbd_1870 heptosyltransferase family protein. (404 aa)
Your Current Organism:
Xanthobacter autotrophicus
NCBI taxonomy Id: 78245
Other names: X. autotrophicus Py2, Xanthobacter autotrophicus Py2, Xanthobacter autotrophicus str. Py2, Xanthobacter autotrophicus strain Py2, Xanthobacter sp. Py2
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