(102 nodes) Mixed, incl. SH2 domain superfamily, and ERBB signaling pathway network (Callorhinchus milii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	stap2	Uncharacterized protein. (375 aa)
	gab2	PH domain-containing protein. (686 aa)
	ENSCMIP00000000809	Uncharacterized protein. (60 aa)
	sh3gl1	Uncharacterized protein. (368 aa)
	spry4	Uncharacterized protein. (323 aa)
	pag1	Uncharacterized protein. (416 aa)
	apbb1ip	Uncharacterized protein. (667 aa)
	frs3	IRS-type PTB domain-containing protein. (525 aa)
	ENSCMIP00000003755	Uncharacterized protein. (93 aa)
	LOC103173145	Ras-GEF domain-containing protein. (229 aa)
	matk	Tyrosine-protein kinase. (447 aa)
	ENSCMIP00000005660	Tyrosine-protein phosphatase domain-containing protein. (344 aa)
	ENSCMIP00000005884	Ig-like domain-containing protein. (139 aa)
	LOC103191373	Uncharacterized protein. (627 aa)
	LOC103172791	Uncharacterized protein. (299 aa)
	ENSCMIP00000007154	Focal_AT domain-containing protein. (111 aa)
	ENSCMIP00000007173	Uncharacterized protein. (116 aa)
	LOC103172958	Uncharacterized protein. (210 aa)
	ENSCMIP00000008232	Uncharacterized protein. (213 aa)
	ENSCMIP00000008238	Uncharacterized protein. (98 aa)
	ENSCMIP00000008602	PH domain-containing protein. (145 aa)
	Spry3	Uncharacterized protein. (290 aa)
	insr	Tyrosine-protein kinase receptor. (1382 aa)
	ENSCMIP00000008878	Uncharacterized protein. (93 aa)
	ENSCMIP00000009067	FERM domain-containing protein. (95 aa)
	ENSCMIP00000010071	Uncharacterized protein. (1058 aa)
	sos1	Uncharacterized protein. (1322 aa)
	shc2	Uncharacterized protein. (576 aa)
	erbb3	Protein kinase domain-containing protein. (1213 aa)
	ENSCMIP00000012950	Neuregulin domain-containing protein. (266 aa)
	Nrg2	Uncharacterized protein. (397 aa)
	hbegf	EGF-like domain-containing protein. (214 aa)
	LOC103175371	Tyrosine-protein kinase. (522 aa)
	tgfa	EGF-like domain-containing protein. (383 aa)
	egf	Uncharacterized protein. (1070 aa)
	fgfr2	Fibroblast growth factor receptor. (841 aa)
	usp15	Ubiquitin carboxyl-terminal hydrolase. (995 aa)
	sh3gl2	Uncharacterized protein. (393 aa)
	nedd9	SH3 domain-containing protein. (849 aa)
	grb14	Uncharacterized protein. (560 aa)
	erbb2	Receptor protein-tyrosine kinase. (1160 aa)
	memo1	Protein MEMO1-like protein. (297 aa)
	ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
	ENSCMIP00000017639	IlGF domain-containing protein. (201 aa)
	grap	GRB2-related adapter protein. (216 aa)
	igf1r	Tyrosine-protein kinase receptor. (1361 aa)
	irs1	Uncharacterized protein. (1131 aa)
	LOC103190988	Tyrosine-protein kinase. (465 aa)
	Sh2d6	SH2 domain-containing protein. (159 aa)
	met	Uncharacterized protein. (1423 aa)
	cd2ap	Uncharacterized protein. (746 aa)
	sh3kbp1	Uncharacterized protein. (647 aa)
	LOC103178146	Tyrosine-protein kinase. (455 aa)
	spry1	Uncharacterized protein. (305 aa)
	csk	Tyrosine-protein kinase. (499 aa)
	sla2	Src-like-adapter 2-like protein. (291 aa)
	sh2b2	PH domain-containing protein. (432 aa)
	Shc3	PID domain-containing protein. (117 aa)
	ENSCMIP00000026954	PID domain-containing protein. (98 aa)
	sos2	Uncharacterized protein. (1335 aa)
	ENSCMIP00000030897	SH3 domain-containing protein. (54 aa)
	sh3d21	Uncharacterized protein. (457 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (465 aa)
	nrg1	Uncharacterized protein. (605 aa)
	rap1a	Uncharacterized protein. (185 aa)
	ENSCMIP00000034491	SH3 domain-containing protein. (887 aa)
	erbb4	Receptor protein-tyrosine kinase. (1325 aa)
	LOC103187442	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
	vav2	Uncharacterized protein. (767 aa)
	cbl	Cbl-PTB domain-containing protein. (134 aa)
	lck	Tyrosine-protein kinase. (511 aa)
	sh2d1a	SH2 domain-containing protein 1A-like protein. (120 aa)
	fyn	Tyrosine-protein kinase. (545 aa)
	fgr	Tyrosine-protein kinase. (571 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (633 aa)
	srms	Tyrosine-protein kinase. (451 aa)
	ptk6	Tyrosine-protein kinase. (491 aa)
	LOC103178759	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
	lyn	Tyrosine-protein kinase. (512 aa)
	LOC103177105	SH2 domain-containing protein. (140 aa)
	LOC103190626	Uncharacterized protein. (61 aa)
	yes1	Tyrosine-protein kinase. (540 aa)
	ENSCMIP00000040680	Uncharacterized protein. (178 aa)
	ereg	EGF-like domain-containing protein. (159 aa)
	LOC103177685	EGF-like domain-containing protein. (239 aa)
	btc	EGF-like domain-containing protein. (169 aa)
	hck	Tyrosine-protein kinase. (512 aa)
	blnk	SH2 domain-containing protein. (518 aa)
	ENSCMIP00000043212	Sema domain-containing protein. (593 aa)
	mst1r	Protein kinase domain-containing protein. (242 aa)
	grb2	Uncharacterized protein. (246 aa)
	fer	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (824 aa)
	grb10	Uncharacterized protein. (607 aa)
	ide	Uncharacterized protein; Belongs to the peptidase M16 family. (1008 aa)
	synj2	SAC domain-containing protein. (984 aa)
	rasgrf1	Uncharacterized protein. (1171 aa)
	hras	GTPase HRas-like protein. (189 aa)
	egfr	Receptor protein-tyrosine kinase. (1203 aa)
	gab1	PH domain-containing protein. (687 aa)
	cblb	Cas-Br-M (Murine) ecotropic retroviral transforming sequence b. (977 aa)
	LOC103175602	Uncharacterized protein. (559 aa)
	shc4	Uncharacterized protein. (484 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000000809	ENSCMIP00000043212	ENSCMIP00000000809	ENSCMIP00000043212	Uncharacterized protein.	Sema domain-containing protein.	0.626
ENSCMIP00000000809	apbb1ip	ENSCMIP00000000809	ENSCMIP00000003076	Uncharacterized protein.	Uncharacterized protein.	0.420
ENSCMIP00000000809	grb2	ENSCMIP00000000809	ENSCMIP00000043216	Uncharacterized protein.	Uncharacterized protein.	0.474
ENSCMIP00000000809	met	ENSCMIP00000000809	ENSCMIP00000021975	Uncharacterized protein.	Uncharacterized protein.	0.626
ENSCMIP00000000809	mst1r	ENSCMIP00000000809	ENSCMIP00000043214	Uncharacterized protein.	Protein kinase domain-containing protein.	0.626
ENSCMIP00000003755	ENSCMIP00000005660	ENSCMIP00000003755	ENSCMIP00000005660	Uncharacterized protein.	Tyrosine-protein phosphatase domain-containing protein.	0.450
ENSCMIP00000003755	ENSCMIP00000007173	ENSCMIP00000003755	ENSCMIP00000007173	Uncharacterized protein.	Uncharacterized protein.	0.479
ENSCMIP00000003755	ENSCMIP00000030897	ENSCMIP00000003755	ENSCMIP00000030897	Uncharacterized protein.	SH3 domain-containing protein.	0.440
ENSCMIP00000003755	ENSCMIP00000034491	ENSCMIP00000003755	ENSCMIP00000034491	Uncharacterized protein.	SH3 domain-containing protein.	0.637
ENSCMIP00000003755	ENSCMIP00000043212	ENSCMIP00000003755	ENSCMIP00000043212	Uncharacterized protein.	Sema domain-containing protein.	0.446
ENSCMIP00000003755	LOC103173145	ENSCMIP00000003755	ENSCMIP00000003918	Uncharacterized protein.	Ras-GEF domain-containing protein.	0.479
ENSCMIP00000003755	LOC103175371	ENSCMIP00000003755	ENSCMIP00000013056	Uncharacterized protein.	Tyrosine-protein kinase.	0.459
ENSCMIP00000003755	LOC103187442	ENSCMIP00000003755	ENSCMIP00000035285	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.450
ENSCMIP00000003755	LOC103190626	ENSCMIP00000003755	ENSCMIP00000039525	Uncharacterized protein.	Uncharacterized protein.	0.479
ENSCMIP00000003755	LOC103190988	ENSCMIP00000003755	ENSCMIP00000018973	Uncharacterized protein.	Tyrosine-protein kinase.	0.589
ENSCMIP00000003755	apbb1ip	ENSCMIP00000003755	ENSCMIP00000003076	Uncharacterized protein.	Uncharacterized protein.	0.460
ENSCMIP00000003755	csk	ENSCMIP00000003755	ENSCMIP00000025934	Uncharacterized protein.	Tyrosine-protein kinase.	0.585
ENSCMIP00000003755	egfr	ENSCMIP00000003755	ENSCMIP00000047461	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.505
ENSCMIP00000003755	erbb2	ENSCMIP00000003755	ENSCMIP00000017167	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.505
ENSCMIP00000003755	erbb3	ENSCMIP00000003755	ENSCMIP00000012625	Uncharacterized protein.	Protein kinase domain-containing protein.	0.505