(6 nodes) Insulin receptor complex, and Insulin family network (Callorhinchus milii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	insr	Tyrosine-protein kinase receptor. (1382 aa)
	ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
	ENSCMIP00000017639	IlGF domain-containing protein. (201 aa)
	igf1r	Tyrosine-protein kinase receptor. (1361 aa)
	irs1	Uncharacterized protein. (1131 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (465 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000017639	igf1r	ENSCMIP00000017639	ENSCMIP00000017678	IlGF domain-containing protein.	Tyrosine-protein kinase receptor.	0.952
ENSCMIP00000017639	ins	ENSCMIP00000017639	ENSCMIP00000017634	IlGF domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.553
ENSCMIP00000017639	insr	ENSCMIP00000017639	ENSCMIP00000008789	IlGF domain-containing protein.	Tyrosine-protein kinase receptor.	0.869
igf1r	ENSCMIP00000017639	ENSCMIP00000017678	ENSCMIP00000017639	Tyrosine-protein kinase receptor.	IlGF domain-containing protein.	0.952
igf1r	ins	ENSCMIP00000017678	ENSCMIP00000017634	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.989
igf1r	irs1	ENSCMIP00000017678	ENSCMIP00000018745	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.980
igf1r	ptpn1	ENSCMIP00000017678	ENSCMIP00000031923	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type.	0.801
ins	ENSCMIP00000017639	ENSCMIP00000017634	ENSCMIP00000017639	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	IlGF domain-containing protein.	0.553
ins	igf1r	ENSCMIP00000017634	ENSCMIP00000017678	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.989
ins	insr	ENSCMIP00000017634	ENSCMIP00000008789	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine-protein kinase receptor.	0.899
ins	irs1	ENSCMIP00000017634	ENSCMIP00000018745	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.976
insr	ENSCMIP00000017639	ENSCMIP00000008789	ENSCMIP00000017639	Tyrosine-protein kinase receptor.	IlGF domain-containing protein.	0.869
insr	ins	ENSCMIP00000008789	ENSCMIP00000017634	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.899
insr	irs1	ENSCMIP00000008789	ENSCMIP00000018745	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.810
insr	ptpn1	ENSCMIP00000008789	ENSCMIP00000031923	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type.	0.801
irs1	igf1r	ENSCMIP00000018745	ENSCMIP00000017678	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.980
irs1	ins	ENSCMIP00000018745	ENSCMIP00000017634	Uncharacterized protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.976
irs1	insr	ENSCMIP00000018745	ENSCMIP00000008789	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.810
irs1	ptpn1	ENSCMIP00000018745	ENSCMIP00000031923	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type.	0.918
ptpn1	igf1r	ENSCMIP00000031923	ENSCMIP00000017678	Tyrosine-protein phosphatase non-receptor type.	Tyrosine-protein kinase receptor.	0.801