(59 nodes) Mixed, incl. PI3K Cascade, and PDGF/VEGF domain network (Callorhinchus milii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	ENSCMIP00000001653	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (112 aa)
	LOC103184142	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (390 aa)
	LOC103182483	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	angptl7	Fibrinogen C-terminal domain-containing protein. (348 aa)
	vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (425 aa)
	tie1	Uncharacterized protein. (1175 aa)
	LOC103190808	Placenta growth factor-like protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	fgf11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	vegfa	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
	LOC103172519	Protein kinase domain-containing protein. (156 aa)
	pdgfa	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (244 aa)
	LOC103189714	Fibroblast growth factor receptor. (735 aa)
	ENSCMIP00000011754	Uncharacterized protein. (292 aa)
	ydjc	Uncharacterized protein. (317 aa)
	ENSCMIP00000012919	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (494 aa)
	flt4	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1346 aa)
	Fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	sh2b3	SH2 domain-containing protein. (588 aa)
	Fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	tek	Uncharacterized protein. (1136 aa)
	lct	Uncharacterized protein. (1898 aa)
	flt3	Uncharacterized protein. (653 aa)
	LOC103176000	Uncharacterized protein. (607 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	fgf9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	Vegfd	Uncharacterized protein. (159 aa)
	Kitlg	Uncharacterized protein. (123 aa)
	fgfr3	Fibroblast growth factor receptor. (776 aa)
	fgfrl1	Uncharacterized protein. (478 aa)
	igf1	IlGF domain-containing protein. (151 aa)
	fgf13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
	klb	Uncharacterized protein. (1007 aa)
	ENSCMIP00000028505	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (229 aa)
	fgf23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	kit	Mast/stem cell growth factor receptor. (968 aa)
	kdr	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1351 aa)
	angpt1	Fibrinogen C-terminal domain-containing protein. (498 aa)
	LOC103187308	Fibrinogen C-terminal domain-containing protein. (499 aa)
	ENSCMIP00000031375	Uncharacterized protein. (168 aa)
	fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC103190034	Thyroglobulin type-1 domain-containing protein. (150 aa)
	hgf	Uncharacterized protein; Belongs to the peptidase S1 family. (745 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (178 aa)
	pdgfd	Platelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (373 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	fn1	Uncharacterized protein. (2446 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
	LOC103190693	Fibroblast growth factor receptor. (697 aa)
	LOC103185197	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
	anos1	Uncharacterized protein. (681 aa)
	lctl	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (579 aa)
	LOC103175503	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (195 aa)
	LOC103177279	Uncharacterized protein. (493 aa)
	frs2	IRS-type PTB domain-containing protein. (510 aa)
	fgf18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000001653	ENSCMIP00000011754	ENSCMIP00000001653	ENSCMIP00000011754	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.662
ENSCMIP00000001653	ENSCMIP00000028505	ENSCMIP00000001653	ENSCMIP00000028505	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.458
ENSCMIP00000001653	Fgf22	ENSCMIP00000001653	ENSCMIP00000014234	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.573
ENSCMIP00000001653	Fgf5	ENSCMIP00000001653	ENSCMIP00000014813	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.632
ENSCMIP00000001653	LOC103172519	ENSCMIP00000001653	ENSCMIP00000009697	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Protein kinase domain-containing protein.	0.662
ENSCMIP00000001653	LOC103176000	ENSCMIP00000001653	ENSCMIP00000019689	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.677
ENSCMIP00000001653	LOC103177279	ENSCMIP00000001653	ENSCMIP00000047549	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.662
ENSCMIP00000001653	LOC103185197	ENSCMIP00000001653	ENSCMIP00000043016	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.587
ENSCMIP00000001653	LOC103189714	ENSCMIP00000001653	ENSCMIP00000011731	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.662
ENSCMIP00000001653	LOC103190693	ENSCMIP00000001653	ENSCMIP00000041543	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.662
ENSCMIP00000001653	anos1	ENSCMIP00000001653	ENSCMIP00000043964	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.677
ENSCMIP00000001653	fgf10	ENSCMIP00000001653	ENSCMIP00000048693	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.573
ENSCMIP00000001653	fgf18	ENSCMIP00000001653	ENSCMIP00000048558	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
ENSCMIP00000001653	fgf19	ENSCMIP00000001653	ENSCMIP00000041094	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.608
ENSCMIP00000001653	fgf23	ENSCMIP00000001653	ENSCMIP00000029354	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.608
ENSCMIP00000001653	fgf3	ENSCMIP00000001653	ENSCMIP00000041162	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.801
ENSCMIP00000001653	fgf4	ENSCMIP00000001653	ENSCMIP00000041134	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.587
ENSCMIP00000001653	fgf7	ENSCMIP00000001653	ENSCMIP00000048807	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.505
ENSCMIP00000001653	fgfr3	ENSCMIP00000001653	ENSCMIP00000022472	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.662
ENSCMIP00000001653	fgfrl1	ENSCMIP00000001653	ENSCMIP00000024402	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.662