(51 nodes) HDACs deacetylate histones, and Histone deacetylase family network (Callorhinchus milii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103172057	Integrase catalytic domain-containing protein. (358 aa)
	LOC103174056	CHDCT2 domain-containing protein. (87 aa)
	hmg20b	HMG box domain-containing protein. (349 aa)
	arid4a	ARID domain-containing protein. (1227 aa)
	LOC103181325	HMG box domain-containing protein. (415 aa)
	ENSCMIP00000003412	Helicase ATP-binding domain-containing protein. (92 aa)
	brms1l	Breast cancer metastasis-suppressor 1-like protein-A. (325 aa)
	LOC103173630	DUF1087 domain-containing protein. (191 aa)
	LOC103174007	SNF2_N domain-containing protein. (99 aa)
	hdac8	Hist_deacetyl domain-containing protein. (356 aa)
	sap30	Uncharacterized protein. (228 aa)
	LOC103182089	Protein kinase domain-containing protein. (385 aa)
	ENSCMIP00000008332	Uncharacterized protein. (89 aa)
	arid5a	ARID domain-containing protein. (447 aa)
	mta3	Uncharacterized protein. (610 aa)
	mbd3	MBD domain-containing protein. (258 aa)
	gatad2a	GATA-type domain-containing protein. (636 aa)
	sin3a	HDAC_interact domain-containing protein. (1277 aa)
	rreb1	Uncharacterized protein. (1778 aa)
	ENSCMIP00000011539	Integrase catalytic domain-containing protein. (378 aa)
	rcor3	Uncharacterized protein. (520 aa)
	sin3b	HDAC_interact domain-containing protein. (1155 aa)
	hdac3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (425 aa)
	hdac9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
	rest	Uncharacterized protein. (887 aa)
	chd5	Uncharacterized protein. (1593 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1097 aa)
	suds3	Sin3 histone deacetylase corepressor complex component SDS3-like protein. (366 aa)
	calml6	Uncharacterized protein. (156 aa)
	phf21a	PHD-type domain-containing protein. (632 aa)
	chd2	Uncharacterized protein. (1815 aa)
	ENSCMIP00000023828	Uncharacterized protein. (350 aa)
	ENSCMIP00000025820	RT_RNaseH_2 domain-containing protein. (130 aa)
	arid4b	ARID domain-containing protein. (1308 aa)
	ENSCMIP00000029747	Uncharacterized protein. (240 aa)
	wdr73	Uncharacterized protein. (368 aa)
	ing1	Inhibitor of growth protein. (275 aa)
	Znf217	Uncharacterized protein. (1008 aa)
	phf12	Uncharacterized protein. (977 aa)
	phf21b	Uncharacterized protein. (364 aa)
	rbbp4	WD_REPEATS_REGION domain-containing protein. (556 aa)
	hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1090 aa)
	mta1	Uncharacterized protein. (727 aa)
	cdk2ap1	Uncharacterized protein. (210 aa)
	rcor1	Uncharacterized protein. (405 aa)
	ENSCMIP00000037495	Hist_deacetyl domain-containing protein. (571 aa)
	LOC103187519	Uncharacterized protein. (727 aa)
	ENSCMIP00000039051	Uncharacterized protein. (86 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (765 aa)
	camk4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (456 aa)
	morf4l1	MRG domain-containing protein. (310 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCMIP00000003412	ENSCMIP00000008332	ENSCMIP00000003412	ENSCMIP00000008332	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.633
ENSCMIP00000003412	ENSCMIP00000011539	ENSCMIP00000003412	ENSCMIP00000011539	Helicase ATP-binding domain-containing protein.	Integrase catalytic domain-containing protein.	0.653
ENSCMIP00000003412	ENSCMIP00000025820	ENSCMIP00000003412	ENSCMIP00000025820	Helicase ATP-binding domain-containing protein.	RT_RNaseH_2 domain-containing protein.	0.653
ENSCMIP00000003412	ENSCMIP00000039051	ENSCMIP00000003412	ENSCMIP00000039051	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.513
ENSCMIP00000003412	LOC103172057	ENSCMIP00000003412	ENSCMIP00000000182	Helicase ATP-binding domain-containing protein.	Integrase catalytic domain-containing protein.	0.653
ENSCMIP00000003412	LOC103173630	ENSCMIP00000003412	ENSCMIP00000004790	Helicase ATP-binding domain-containing protein.	DUF1087 domain-containing protein.	0.900
ENSCMIP00000003412	LOC103174007	ENSCMIP00000003412	ENSCMIP00000006098	Helicase ATP-binding domain-containing protein.	SNF2_N domain-containing protein.	0.899
ENSCMIP00000003412	LOC103187519	ENSCMIP00000003412	ENSCMIP00000038733	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.633
ENSCMIP00000003412	arid4a	ENSCMIP00000003412	ENSCMIP00000002543	Helicase ATP-binding domain-containing protein.	ARID domain-containing protein.	0.729
ENSCMIP00000003412	arid4b	ENSCMIP00000003412	ENSCMIP00000026045	Helicase ATP-binding domain-containing protein.	ARID domain-containing protein.	0.729
ENSCMIP00000003412	cdk2ap1	ENSCMIP00000003412	ENSCMIP00000034613	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.489
ENSCMIP00000003412	gatad2a	ENSCMIP00000003412	ENSCMIP00000009756	Helicase ATP-binding domain-containing protein.	GATA-type domain-containing protein.	0.811
ENSCMIP00000003412	hdac3	ENSCMIP00000003412	ENSCMIP00000012887	Helicase ATP-binding domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.639
ENSCMIP00000003412	hdac8	ENSCMIP00000003412	ENSCMIP00000006376	Helicase ATP-binding domain-containing protein.	Hist_deacetyl domain-containing protein.	0.639
ENSCMIP00000003412	hmg20b	ENSCMIP00000003412	ENSCMIP00000001706	Helicase ATP-binding domain-containing protein.	HMG box domain-containing protein.	0.473
ENSCMIP00000003412	kdm1a	ENSCMIP00000003412	ENSCMIP00000039456	Helicase ATP-binding domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.687
ENSCMIP00000003412	mbd3	ENSCMIP00000003412	ENSCMIP00000009360	Helicase ATP-binding domain-containing protein.	MBD domain-containing protein.	0.804
ENSCMIP00000003412	morf4l1	ENSCMIP00000003412	ENSCMIP00000043630	Helicase ATP-binding domain-containing protein.	MRG domain-containing protein.	0.421
ENSCMIP00000003412	mta1	ENSCMIP00000003412	ENSCMIP00000034356	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.633
ENSCMIP00000003412	mta3	ENSCMIP00000003412	ENSCMIP00000008685	Helicase ATP-binding domain-containing protein.	Uncharacterized protein.	0.633