(71 nodes) Positive regulation of epithelial cell migration network (Callorhinchus milii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpi	Glucose-6-phosphate isomerase; Belongs to the GPI family. (577 aa)
	ENSCMIP00000000236	Uncharacterized protein. (100 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	LOC103173436	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (356 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (631 aa)
	ENSCMIP00000001084	Uncharacterized protein. (90 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (562 aa)
	LOC103175665	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1119 aa)
	LOC103174430	PI-PLC Y-box domain-containing protein. (79 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2532 aa)
	tsta3	Epimerase domain-containing protein. (272 aa)
	LOC103173319	Uncharacterized protein. (274 aa)
	vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (425 aa)
	ENSCMIP00000007074	Uncharacterized protein. (127 aa)
	LOC103172825	Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
	lgmn	Uncharacterized protein. (436 aa)
	ENSCMIP00000008602	PH domain-containing protein. (145 aa)
	vegfa	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
	ENSCMIP00000009879	Uncharacterized protein. (1362 aa)
	rreb1	Uncharacterized protein. (1778 aa)
	LOC103179218	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (176 aa)
	nus1	Nogo-B receptor. (264 aa)
	ENSCMIP00000012724	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (313 aa)
	aamp	WD_REPEATS_REGION domain-containing protein. (419 aa)
	bsg	Uncharacterized protein. (299 aa)
	ENSCMIP00000015182	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (325 aa)
	LOC103183769	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (350 aa)
	LOC103183768	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (350 aa)
	LOC103183767	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (354 aa)
	agt	SERPIN domain-containing protein; Belongs to the serpin family. (461 aa)
	ENSCMIP00000017639	IlGF domain-containing protein. (201 aa)
	sash1	Uncharacterized protein. (1223 aa)
	atp5f1b	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (582 aa)
	itgb1bp1	Integrin beta-1-binding protein 1. (200 aa)
	cib1	Uncharacterized protein. (194 aa)
	adam17	Uncharacterized protein. (883 aa)
	atp5f1a	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (570 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (930 aa)
	met	Uncharacterized protein. (1423 aa)
	plpp3	acidPPc domain-containing protein. (306 aa)
	ifng	Uncharacterized protein. (166 aa)
	LOC103189936	Uncharacterized protein. (265 aa)
	ENSCMIP00000028505	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (229 aa)
	Gata2	Uncharacterized protein. (186 aa)
	nfe2l2	BZIP domain-containing protein. (660 aa)
	ENSCMIP00000030103	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (337 aa)
	Arf6	Uncharacterized protein. (156 aa)
	Bmpr2	Uncharacterized protein. (384 aa)
	ENSCMIP00000030650	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (468 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	LOC103191371	TNFR-Cys domain-containing protein. (370 aa)
	LOC103191377	TNFR-Cys domain-containing protein. (279 aa)
	ENSCMIP00000036146	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
	ENSCMIP00000036870	Uncharacterized protein. (156 aa)
	ENSCMIP00000036876	Uncharacterized protein. (186 aa)
	bcas3	BCAS3 domain-containing protein. (917 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1289 aa)
	hspb1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (224 aa)
	sp1	Uncharacterized protein. (751 aa)
	glipr2	SCP domain-containing protein; Belongs to the CRISP family. (163 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
	ENSCMIP00000043212	Sema domain-containing protein. (593 aa)
	mst1r	Protein kinase domain-containing protein. (242 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (330 aa)
	rin2	Uncharacterized protein. (891 aa)
	zc3h12a	C3H1-type domain-containing protein. (701 aa)
	jun	Jun domain-containing protein. (350 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1087 aa)
	fgf18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	capn7	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (793 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arf6	ENSCMIP00000043212	ENSCMIP00000030532	ENSCMIP00000043212	Uncharacterized protein.	Sema domain-containing protein.	0.726
Arf6	LOC103179218	ENSCMIP00000030532	ENSCMIP00000011328	Uncharacterized protein.	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.902
Arf6	met	ENSCMIP00000030532	ENSCMIP00000021975	Uncharacterized protein.	Uncharacterized protein.	0.726
Arf6	mst1r	ENSCMIP00000030532	ENSCMIP00000043214	Uncharacterized protein.	Protein kinase domain-containing protein.	0.726
Bmpr2	ENSCMIP00000030650	ENSCMIP00000030641	ENSCMIP00000030650	Uncharacterized protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.900
Bmpr2	ENSCMIP00000036146	ENSCMIP00000030641	ENSCMIP00000036146	Uncharacterized protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.664
Bmpr2	LOC103172825	ENSCMIP00000030641	ENSCMIP00000007181	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.407
Bmpr2	tgfb2	ENSCMIP00000030641	ENSCMIP00000042795	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.407
Bmpr2	tgfbr2	ENSCMIP00000030641	ENSCMIP00000002498	Uncharacterized protein.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.844
ENSCMIP00000000236	jun	ENSCMIP00000000236	ENSCMIP00000047489	Uncharacterized protein.	Jun domain-containing protein.	0.507
ENSCMIP00000001084	jun	ENSCMIP00000001084	ENSCMIP00000047489	Uncharacterized protein.	Jun domain-containing protein.	0.507
ENSCMIP00000007074	fgf1	ENSCMIP00000007074	ENSCMIP00000000508	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.443
ENSCMIP00000007074	fgf7	ENSCMIP00000007074	ENSCMIP00000048807	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
ENSCMIP00000008602	fgf1	ENSCMIP00000008602	ENSCMIP00000000508	PH domain-containing protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.443
ENSCMIP00000008602	fgf7	ENSCMIP00000008602	ENSCMIP00000048807	PH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
ENSCMIP00000017639	met	ENSCMIP00000017639	ENSCMIP00000021975	IlGF domain-containing protein.	Uncharacterized protein.	0.719
ENSCMIP00000028505	fgf1	ENSCMIP00000028505	ENSCMIP00000000508	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.547
ENSCMIP00000028505	fgf7	ENSCMIP00000028505	ENSCMIP00000048807	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
ENSCMIP00000030650	Bmpr2	ENSCMIP00000030650	ENSCMIP00000030641	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Uncharacterized protein.	0.900
ENSCMIP00000030650	LOC103172825	ENSCMIP00000030650	ENSCMIP00000007181	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.407