(68 nodes) Positive regulation of angiogenesis network (Callorhinchus milii)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	LOC103173436	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (356 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (631 aa)
	aggf1	Uncharacterized protein. (716 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (562 aa)
	mydgf	Uncharacterized protein. (165 aa)
	il10	Uncharacterized protein. (189 aa)
	vegfc	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (425 aa)
	LOC103174033	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (188 aa)
	tbxa2r	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	tie1	Uncharacterized protein. (1175 aa)
	LOC103190808	Placenta growth factor-like protein; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	vegfa	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
	ENSCMIP00000010820	RING-type domain-containing protein. (68 aa)
	brca1	Uncharacterized protein. (1637 aa)
	chrna7	Uncharacterized protein. (501 aa)
	ENSCMIP00000012724	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (313 aa)
	emilin1	Uncharacterized protein. (951 aa)
	ENSCMIP00000015182	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (325 aa)
	LOC103183769	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (350 aa)
	LOC103183768	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (350 aa)
	LOC103183767	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (354 aa)
	tek	Uncharacterized protein. (1136 aa)
	LOC103182147	Interleukin 8. (91 aa)
	xbp1	BZIP domain-containing protein. (266 aa)
	bcl10	Uncharacterized protein. (293 aa)
	LOC103183797	Uncharacterized protein. (260 aa)
	ENSCMIP00000017639	IlGF domain-containing protein. (201 aa)
	sash1	Uncharacterized protein. (1223 aa)
	mdk	PTN_MK_N domain-containing protein. (203 aa)
	LOC103181114	LRRCT domain-containing protein. (340 aa)
	ENSCMIP00000019708	Cyclic nucleotide-binding domain-containing protein. (115 aa)
	btg1	Protein BTG1-like protein. (173 aa)
	Vegfd	Uncharacterized protein. (159 aa)
	ENSCMIP00000022364	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (137 aa)
	ENSCMIP00000022548	Uncharacterized protein. (54 aa)
	ENSCMIP00000022992	Uncharacterized protein. (108 aa)
	sfrp2	Secreted frizzled-related protein 2. (304 aa)
	angptl3	Fibrinogen C-terminal domain-containing protein. (491 aa)
	vash2	Uncharacterized protein. (364 aa)
	LOC103189936	Uncharacterized protein. (265 aa)
	ENSCMIP00000028505	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (229 aa)
	LOC103189967	Uncharacterized protein. (457 aa)
	nfe2l2	BZIP domain-containing protein. (660 aa)
	ENSCMIP00000030103	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (337 aa)
	c5	Uncharacterized protein. (1583 aa)
	LOC103191371	TNFR-Cys domain-containing protein. (370 aa)
	LOC103191377	TNFR-Cys domain-containing protein. (279 aa)
	LOC103178928	Uncharacterized protein; Belongs to the cytochrome P450 family. (518 aa)
	eng	Uncharacterized protein. (677 aa)
	bmper	Uncharacterized protein. (679 aa)
	cdh5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (680 aa)
	ENSCMIP00000037345	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (227 aa)
	ENSCMIP00000037912	Uncharacterized protein; Belongs to the cytochrome P450 family. (161 aa)
	Aplnr	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (401 aa)
	hspb1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (224 aa)
	LOC103190682	Ras-GEF domain-containing protein. (246 aa)
	sp1	Uncharacterized protein. (751 aa)
	LOC103190064	Uncharacterized protein. (807 aa)
	LOC103177743	Uncharacterized protein. (512 aa)
	itgb8	Integrin beta; Belongs to the integrin beta chain family. (831 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (330 aa)
	ENSCMIP00000044976	Uncharacterized protein. (171 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (363 aa)
	zc3h12a	C3H1-type domain-containing protein. (701 aa)
	gab1	PH domain-containing protein. (687 aa)
	fgf18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aplnr	ENSCMIP00000022548	ENSCMIP00000038842	ENSCMIP00000022548	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.925
ENSCMIP00000017639	tek	ENSCMIP00000017639	ENSCMIP00000016337	IlGF domain-containing protein.	Uncharacterized protein.	0.650
ENSCMIP00000022364	vegfc	ENSCMIP00000022364	ENSCMIP00000005405	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.611
ENSCMIP00000022548	Aplnr	ENSCMIP00000022548	ENSCMIP00000038842	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.925
ENSCMIP00000022992	LOC103182147	ENSCMIP00000022992	ENSCMIP00000016498	Uncharacterized protein.	Interleukin 8.	0.888
ENSCMIP00000022992	LOC103189936	ENSCMIP00000022992	ENSCMIP00000028094	Uncharacterized protein.	Uncharacterized protein.	0.491
ENSCMIP00000022992	LOC103191371	ENSCMIP00000022992	ENSCMIP00000034188	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.463
ENSCMIP00000022992	LOC103191377	ENSCMIP00000022992	ENSCMIP00000034191	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.463
ENSCMIP00000022992	il10	ENSCMIP00000022992	ENSCMIP00000004896	Uncharacterized protein.	Uncharacterized protein.	0.789
ENSCMIP00000022992	nfe2l2	ENSCMIP00000022992	ENSCMIP00000030028	Uncharacterized protein.	BZIP domain-containing protein.	0.446
ENSCMIP00000022992	sirt1	ENSCMIP00000022992	ENSCMIP00000001044	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.430
ENSCMIP00000022992	vegfa	ENSCMIP00000022992	ENSCMIP00000009426	Uncharacterized protein.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.400
ENSCMIP00000022992	vegfc	ENSCMIP00000022992	ENSCMIP00000005405	Uncharacterized protein.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.463
ENSCMIP00000028505	fgf1	ENSCMIP00000028505	ENSCMIP00000000508	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.547
LOC103177743	chrna7	ENSCMIP00000043377	ENSCMIP00000011796	Uncharacterized protein.	Uncharacterized protein.	0.901
LOC103181114	eng	ENSCMIP00000019197	ENSCMIP00000034287	LRRCT domain-containing protein.	Uncharacterized protein.	0.623
LOC103182147	ENSCMIP00000022992	ENSCMIP00000016498	ENSCMIP00000022992	Interleukin 8.	Uncharacterized protein.	0.888
LOC103182147	il10	ENSCMIP00000016498	ENSCMIP00000004896	Interleukin 8.	Uncharacterized protein.	0.451
LOC103189936	ENSCMIP00000022992	ENSCMIP00000028094	ENSCMIP00000022992	Uncharacterized protein.	Uncharacterized protein.	0.491
LOC103189936	il10	ENSCMIP00000028094	ENSCMIP00000004896	Uncharacterized protein.	Uncharacterized protein.	0.589