(23 nodes) (2022) Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents. network (Callorhinchus milii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nod1	Uncharacterized protein. (862 aa)
	mdm2	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family. (452 aa)
	egfr	Receptor protein-tyrosine kinase. (1203 aa)
	anpep	Aminopeptidase. (966 aa)
	ripk2	Uncharacterized protein. (572 aa)
	Bcl2	BH4_2 domain-containing protein. (229 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (607 aa)
	hdac8	Hist_deacetyl domain-containing protein. (356 aa)
	il10	Uncharacterized protein. (189 aa)
	vcp	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
	tacc3	TACC_C domain-containing protein. (910 aa)
	hpgds	Uncharacterized protein. (237 aa)
	irak4	Protein kinase domain-containing protein. (471 aa)
	crbn	Uncharacterized protein. (506 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (505 aa)
	fat1	Uncharacterized protein. (4641 aa)
	jak1	Tyrosine-protein kinase. (1200 aa)
	xiap	RING-type domain-containing protein. (489 aa)
	tyk2	Tyrosine-protein kinase. (1194 aa)
	cdk6	Protein kinase domain-containing protein. (314 aa)
	htt	Uncharacterized protein. (3124 aa)
	ar	Uncharacterized protein. (459 aa)
	jak2	Tyrosine-protein kinase. (1131 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	il10	ENSCMIP00000014750	ENSCMIP00000004896	BH4_2 domain-containing protein.	Uncharacterized protein.	0.436
ar	esr1	ENSCMIP00000041410	ENSCMIP00000013761	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.499
ar	hdac1	ENSCMIP00000041410	ENSCMIP00000034400	Uncharacterized protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.506
ar	hdac8	ENSCMIP00000041410	ENSCMIP00000006376	Uncharacterized protein.	Hist_deacetyl domain-containing protein.	0.506
ar	htt	ENSCMIP00000041410	ENSCMIP00000041392	Uncharacterized protein.	Uncharacterized protein.	0.589
ar	mdm2	ENSCMIP00000041410	ENSCMIP00000047586	Uncharacterized protein.	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.	0.954
cdk6	mdm2	ENSCMIP00000039810	ENSCMIP00000047586	Protein kinase domain-containing protein.	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.	0.509
crbn	mdm2	ENSCMIP00000032258	ENSCMIP00000047586	Uncharacterized protein.	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.	0.599
crbn	ripk2	ENSCMIP00000032258	ENSCMIP00000019568	Uncharacterized protein.	Uncharacterized protein.	0.529
egfr	esr1	ENSCMIP00000047461	ENSCMIP00000013761	Receptor protein-tyrosine kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.560
esr1	ar	ENSCMIP00000013761	ENSCMIP00000041410	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.499
esr1	egfr	ENSCMIP00000013761	ENSCMIP00000047461	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Receptor protein-tyrosine kinase.	0.560
esr1	hdac1	ENSCMIP00000013761	ENSCMIP00000034400	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.482
esr1	hdac8	ENSCMIP00000013761	ENSCMIP00000006376	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Hist_deacetyl domain-containing protein.	0.482
esr1	mdm2	ENSCMIP00000013761	ENSCMIP00000047586	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.	0.578
hdac1	ar	ENSCMIP00000034400	ENSCMIP00000041410	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Uncharacterized protein.	0.506
hdac1	esr1	ENSCMIP00000034400	ENSCMIP00000013761	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.482
hdac1	mdm2	ENSCMIP00000034400	ENSCMIP00000047586	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.	0.476
hdac8	ar	ENSCMIP00000006376	ENSCMIP00000041410	Hist_deacetyl domain-containing protein.	Uncharacterized protein.	0.506
hdac8	esr1	ENSCMIP00000006376	ENSCMIP00000013761	Hist_deacetyl domain-containing protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.482