(9 nodes) (2023) How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member. network (Callorhinchus milii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	actg1	Uncharacterized protein. (376 aa)
	hdac2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (509 aa)
	hdac3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (425 aa)
	hdac9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
	hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1097 aa)
	tmem263	Uncharacterized protein. (168 aa)
	hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1090 aa)
	hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (505 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (363 aa)

Your Current Organism:

Callorhinchus milii

NCBI taxonomy Id: 7868
Other names: Australian ghost shark, C. milii, elephant fish, elephant shark, ghost shark, makorepe, plownose chimaera, reperepe

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hdac1	hdac2	ENSCMIP00000034400	ENSCMIP00000010916	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.442
hdac1	hdac4	ENSCMIP00000034400	ENSCMIP00000034306	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.667
hdac1	hdac5	ENSCMIP00000034400	ENSCMIP00000016835	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.611
hdac1	hdac9	ENSCMIP00000034400	ENSCMIP00000013557	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.623
hdac1	sirt6	ENSCMIP00000034400	ENSCMIP00000045373	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Deacetylase sirtuin-type domain-containing protein.	0.419
hdac2	hdac1	ENSCMIP00000010916	ENSCMIP00000034400	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.442
hdac2	hdac4	ENSCMIP00000010916	ENSCMIP00000034306	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.681
hdac2	hdac5	ENSCMIP00000010916	ENSCMIP00000016835	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.611
hdac2	hdac9	ENSCMIP00000010916	ENSCMIP00000013557	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.622
hdac2	sirt6	ENSCMIP00000010916	ENSCMIP00000045373	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Deacetylase sirtuin-type domain-containing protein.	0.419
hdac3	hdac4	ENSCMIP00000012887	ENSCMIP00000034306	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.611
hdac3	hdac5	ENSCMIP00000012887	ENSCMIP00000016835	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.618
hdac3	hdac9	ENSCMIP00000012887	ENSCMIP00000013557	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.628
hdac3	sirt6	ENSCMIP00000012887	ENSCMIP00000045373	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Deacetylase sirtuin-type domain-containing protein.	0.419
hdac4	hdac1	ENSCMIP00000034306	ENSCMIP00000034400	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.667
hdac4	hdac2	ENSCMIP00000034306	ENSCMIP00000010916	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.681
hdac4	hdac3	ENSCMIP00000034306	ENSCMIP00000012887	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.611
hdac4	hdac5	ENSCMIP00000034306	ENSCMIP00000016835	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.901
hdac4	sirt6	ENSCMIP00000034306	ENSCMIP00000045373	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Deacetylase sirtuin-type domain-containing protein.	0.416
hdac5	hdac1	ENSCMIP00000016835	ENSCMIP00000034400	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.611