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NT5C3B NT5C3B LOC106702268 LOC106702268 LOC102351310 LOC102351310 AK4 AK4 LOC102347240 LOC102347240 LOC102352017 LOC102352017 ADSS1 ADSS1 ADSL ADSL AMPD2 AMPD2 UPP1 UPP1 NT5C3A NT5C3A LOC102357063 LOC102357063 DTYMK DTYMK LOC102355337 LOC102355337 IMPDH2 IMPDH2 ATIC ATIC LOC102354234 LOC102354234 PPAT PPAT DGUOK DGUOK LOC106704948 LOC106704948 AK3 AK3 LOC102362277 LOC102362277 QRICH1 QRICH1 GMPR2 GMPR2 PAICS PAICS LOC102350392 LOC102350392 PDK2 PDK2 NME6 NME6 NME1 NME1 NT5C NT5C GMPR GMPR UCK2 UCK2 ANKRD33B ANKRD33B TTC5 TTC5 GMPS GMPS LOC102349693 LOC102349693 AK5 AK5 RRM1 RRM1 IMPDH1 IMPDH1 PDE1C PDE1C NT5DC4 NT5DC4 PPA2 PPA2 PDE7B PDE7B H3AMS8_LATCH H3AMS8_LATCH AK9 AK9 H3ANZ2_LATCH H3ANZ2_LATCH CMPK1 CMPK1 PDE3B PDE3B ENTPD6 ENTPD6 NT5M NT5M PRPSAP2 PRPSAP2 ADSS2 ADSS2 DCK DCK AK6 AK6 GUK1 GUK1 RRM2 RRM2 GDA GDA ITPA ITPA MANEA MANEA ENTPD8 ENTPD8 NT5C1A NT5C1A TYMP TYMP NME3 NME3 ENTPD4 ENTPD4 H3B0V9_LATCH H3B0V9_LATCH PDE8B PDE8B NME7 NME7 ADA ADA DCTD DCTD ENTPD3 ENTPD3 NUDT12 NUDT12 ENTPD2 ENTPD2 TK1 TK1 CANT1 CANT1 PRPSAP1 PRPSAP1 HDDC3 HDDC3 PDE6C PDE6C H3BAZ9_LATCH H3BAZ9_LATCH NTPCR NTPCR HPRT1 HPRT1 UCK1 UCK1 LOC102345276 LOC102345276 AMPD3 AMPD3 AK7 AK7 ENTPD5 ENTPD5 AMPD1 AMPD1 ADAL ADAL PNP PNP LOC102352541 LOC102352541 ADK ADK PDE8A PDE8A CDA CDA PDE1A PDE1A AK2 AK2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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NT5C3B5'-nucleotidase, cytosolic IIIB. (220 aa)
LOC106702268Uncharacterized protein. (107 aa)
LOC102351310Adenine phosphoribosyltransferase. (119 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (229 aa)
LOC102347240Pribosyltran_N domain-containing protein. (322 aa)
LOC102352017Zgc:174895. (223 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (449 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (500 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (823 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (284 aa)
LOC102357063Uncharacterized protein. (367 aa)
DTYMKDeoxythymidylate kinase. (189 aa)
LOC102355337Zgc:110540. (270 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (524 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (594 aa)
LOC102354234Phosphodiesterase. (711 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (444 aa)
DGUOKDeoxyguanosine kinase. (286 aa)
LOC106704948Uncharacterized protein; Belongs to the adenylate kinase family. (552 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
LOC102362277Uncharacterized protein; Belongs to the 5'-nucleotidase family. (541 aa)
QRICH1Glutamine rich 1. (779 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (350 aa)
PAICSAIRC domain-containing protein. (1029 aa)
LOC102350392Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (214 aa)
PDK2Protein-serine/threonine kinase. (540 aa)
NME6Nucleoside diphosphate kinase. (188 aa)
NME1Nucleoside diphosphate kinase. (172 aa)
NT5C5', 3'-nucleotidase, cytosolic. (199 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
UCK2Uridine-cytidine kinase 2. (180 aa)
ANKRD33BANK_REP_REGION domain-containing protein. (373 aa)
TTC5Tetratricopeptide repeat domain 5. (448 aa)
GMPSGuanine monophosphate synthase. (683 aa)
LOC102349693Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (293 aa)
AK5Adenylate kinase 5; Belongs to the adenylate kinase family. (296 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (763 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (515 aa)
PDE1CPhosphodiesterase. (440 aa)
NT5DC45'-nucleotidase domain containing 4. (475 aa)
PPA2Pyrophosphatase (inorganic) 2. (313 aa)
PDE7BPhosphodiesterase. (421 aa)
H3AMS8_LATCHUncharacterized protein; Belongs to the adenylate kinase family. (171 aa)
AK9Adenylate kinase 9. (1928 aa)
H3ANZ2_LATCHUncharacterized protein. (440 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (213 aa)
PDE3BPhosphodiesterase. (1104 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (425 aa)
NT5M5',3'-nucleotidase, mitochondrial. (242 aa)
PRPSAP2Phosphoribosyl pyrophosphate synthetase associated protein 2. (357 aa)
ADSS2Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (460 aa)
DCKDeoxycytidine kinase. (263 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (174 aa)
GUK1Guanylate kinase 1. (210 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (411 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (192 aa)
MANEAMannosidase endo-alpha. (446 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (528 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (371 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (474 aa)
NME3NME/NM23 nucleoside diphosphate kinase 3; Belongs to the NDK family. (131 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (481 aa)
H3B0V9_LATCHPhosphodiesterase. (538 aa)
PDE8BPhosphodiesterase. (778 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
ADAA_deaminase domain-containing protein. (132 aa)
DCTDdCMP deaminase. (202 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (517 aa)
NUDT12Nudix hydrolase 12. (460 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2b; Belongs to the GDA1/CD39 NTPase family. (500 aa)
TK1Thymidine kinase. (239 aa)
CANT1Calcium activated nucleotidase 1. (400 aa)
PRPSAP1Phosphoribosyl pyrophosphate synthetase associated protein 1. (290 aa)
HDDC3HD domain containing 3. (179 aa)
PDE6CPhosphodiesterase. (838 aa)
H3BAZ9_LATCHAdenylate kinase 5, like; Belongs to the adenylate kinase family. (437 aa)
NTPCRNucleoside-triphosphatase, cancer-related. (196 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (270 aa)
LOC102345276Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (405 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (773 aa)
AK7Adenylate kinase 7. (711 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (431 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (706 aa)
ADALAdenosine deaminase like. (358 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (309 aa)
LOC102352541Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (286 aa)
ADKAdenosine kinase. (302 aa)
PDE8APhosphodiesterase. (808 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (145 aa)
PDE1APhosphodiesterase. (543 aa)
AK2Adenylate kinase 2; Belongs to the adenylate kinase family. (217 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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