(30 nodes) Mixed, incl. p130Cas linkage to MAPK signaling for integrins, and DOCK N-terminus network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (876 aa)
	LOC102364341	Uncharacterized protein. (271 aa)
	H2ZVQ3_LATCH	Uncharacterized protein. (603 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (901 aa)
	TGFB1I1	Transforming growth factor beta 1 induced transcript 1. (586 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (914 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	H3AEM8_LATCH	DHR-1 domain-containing protein; Belongs to the DOCK family. (1002 aa)
	H3AJ41_LATCH	Rho related BTB domain containing 4. (642 aa)
	H3ANT7_LATCH	Uncharacterized protein; Belongs to the DOCK family. (790 aa)
	CRK	CRK proto-oncogene, adaptor protein. (310 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1826 aa)
	ELMO1	Engulfment and cell motility 1. (732 aa)
	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1312 aa)
	LOC102362077	Ras homolog gene family, member Gc. (192 aa)
	ELMO3	Engulfment and cell motility 3. (454 aa)
	RHOG	Ras homolog family member G. (191 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	DOK1	Docking protein 1. (455 aa)
	TLNRD1	Talin rod domain containing 1. (358 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (873 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (899 aa)
	DOCK3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (1648 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1217 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
	RAPGEF6	Uncharacterized protein. (1491 aa)
	ARHGEF25	Uncharacterized protein. (684 aa)
	RAP1A	RAP1A, member of RAS oncogene family b. (185 aa)
	ELMO2	Engulfment and cell motility 2. (724 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL1	ARHGEF25	ENSLACP00000017765	ENSLACP00000021038	Tyrosine-protein kinase.	Uncharacterized protein.	0.411
ABL1	CRK	ENSLACP00000017765	ENSLACP00000011971	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.853
ABL1	CRKL	ENSLACP00000017765	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.961
ABL1	DOK1	ENSLACP00000017765	ENSLACP00000014995	Tyrosine-protein kinase.	Docking protein 1.	0.575
ABL1	LOC102362077	ENSLACP00000017765	ENSLACP00000013451	Tyrosine-protein kinase.	Ras homolog gene family, member Gc.	0.446
ABL1	LOC102364341	ENSLACP00000017765	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.961
ABL1	RHOG	ENSLACP00000017765	ENSLACP00000014649	Tyrosine-protein kinase.	Ras homolog family member G.	0.446
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	ARHGEF25	ENSLACP00000006377	ENSLACP00000021038	Tyrosine-protein kinase.	Uncharacterized protein.	0.411
ABL2	CRK	ENSLACP00000006377	ENSLACP00000011971	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.853
ABL2	CRKL	ENSLACP00000006377	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.961
ABL2	DOK1	ENSLACP00000006377	ENSLACP00000014995	Tyrosine-protein kinase.	Docking protein 1.	0.575
ABL2	LOC102362077	ENSLACP00000006377	ENSLACP00000013451	Tyrosine-protein kinase.	Ras homolog gene family, member Gc.	0.446
ABL2	LOC102364341	ENSLACP00000006377	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.961
ABL2	RHOG	ENSLACP00000006377	ENSLACP00000014649	Tyrosine-protein kinase.	Ras homolog family member G.	0.446
ARHGEF25	ABL1	ENSLACP00000021038	ENSLACP00000017765	Uncharacterized protein.	Tyrosine-protein kinase.	0.411
ARHGEF25	ABL2	ENSLACP00000021038	ENSLACP00000006377	Uncharacterized protein.	Tyrosine-protein kinase.	0.411
ARHGEF25	DOCK1	ENSLACP00000021038	ENSLACP00000015359	Uncharacterized protein.	Dedicator of cytokinesis 1; Belongs to the DOCK family.	0.436
ARHGEF25	DOCK2	ENSLACP00000021038	ENSLACP00000019991	Uncharacterized protein.	Dedicator of cytokinesis 2; Belongs to the DOCK family.	0.436