(12 nodes) Mixed, incl. Estrogen-stimulated signaling through PRKCZ, and SPRE, EVH1 domain network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RASA2	RAS p21 protein activator 2. (821 aa)
	PRKCE	Protein kinase C, epsilon b. (347 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	RASSF5	Ras association domain family member 5. (225 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (430 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (446 aa)
	NF1	Neurofibromin 1. (2814 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (453 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNG7	H3ARU2_LATCH	ENSLACP00000007654	ENSLACP00000012363	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Uncharacterized protein.	0.674
GNG7	HRAS	ENSLACP00000007654	ENSLACP00000020973	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	HRas proto-oncogene, GTPase.	0.674
GNG7	KRAS	ENSLACP00000007654	ENSLACP00000022976	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	KRAS proto-oncogene, GTPase.	0.674
GNG7	NRAS	ENSLACP00000007654	ENSLACP00000020975	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	NRAS proto-oncogene, GTPase.	0.674
GNG7	PRKCE	ENSLACP00000007654	ENSLACP00000006268	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Protein kinase C, epsilon b.	0.908
H3ARU2_LATCH	GNG7	ENSLACP00000012363	ENSLACP00000007654	Uncharacterized protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.674
H3ARU2_LATCH	KRAS	ENSLACP00000012363	ENSLACP00000022976	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.901
H3ARU2_LATCH	NF1	ENSLACP00000012363	ENSLACP00000019331	Uncharacterized protein.	Neurofibromin 1.	0.976
H3ARU2_LATCH	PRKCE	ENSLACP00000012363	ENSLACP00000006268	Uncharacterized protein.	Protein kinase C, epsilon b.	0.938
H3ARU2_LATCH	RASA2	ENSLACP00000012363	ENSLACP00000004504	Uncharacterized protein.	RAS p21 protein activator 2.	0.946
H3ARU2_LATCH	RASSF5	ENSLACP00000012363	ENSLACP00000010778	Uncharacterized protein.	Ras association domain family member 5.	0.949
H3ARU2_LATCH	SPRED1	ENSLACP00000012363	ENSLACP00000013064	Uncharacterized protein.	Sprouty related EVH1 domain containing 1.	0.646
H3ARU2_LATCH	SPRED2	ENSLACP00000012363	ENSLACP00000012068	Uncharacterized protein.	Sprouty related EVH1 domain containing 2.	0.546
H3ARU2_LATCH	SPRED3	ENSLACP00000012363	ENSLACP00000021000	Uncharacterized protein.	Sprouty related EVH1 domain containing 3.	0.416
HRAS	GNG7	ENSLACP00000020973	ENSLACP00000007654	HRas proto-oncogene, GTPase.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.674
HRAS	NF1	ENSLACP00000020973	ENSLACP00000019331	HRas proto-oncogene, GTPase.	Neurofibromin 1.	0.976
HRAS	PRKCE	ENSLACP00000020973	ENSLACP00000006268	HRas proto-oncogene, GTPase.	Protein kinase C, epsilon b.	0.938
HRAS	RASA2	ENSLACP00000020973	ENSLACP00000004504	HRas proto-oncogene, GTPase.	RAS p21 protein activator 2.	0.946
HRAS	RASSF5	ENSLACP00000020973	ENSLACP00000010778	HRas proto-oncogene, GTPase.	Ras association domain family member 5.	0.949
HRAS	SPRED1	ENSLACP00000020973	ENSLACP00000013064	HRas proto-oncogene, GTPase.	Sprouty related EVH1 domain containing 1.	0.646