(57 nodes) Mixed, incl. SH2 domain, and Interleukin receptor SHC signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	H2ZTT6_LATCH	Phosphoinositide phospholipase C. (404 aa)
	ERBB4	Protein kinase domain-containing protein. (479 aa)
	VAV3	Si:ch73-383g2.1. (488 aa)
	H2ZYD7_LATCH	Protein kinase domain-containing protein. (330 aa)
	BLNK	B cell linker. (546 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	LCP2	Lymphocyte cytosolic protein 2. (518 aa)
	ERBB4-2	Protein kinase domain-containing protein. (789 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	GAB2	GRB2 associated binding protein 2. (550 aa)
	SRMS	Tyrosine-protein kinase. (497 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1220 aa)
	CD247	CD247 molecule. (166 aa)
	PAG1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (427 aa)
	PTPN12	Protein tyrosine phosphatase non-receptor type 12. (785 aa)
	LOC102351732	Uncharacterized protein. (192 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (502 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (586 aa)
	SRC	Tyrosine-protein kinase. (535 aa)
	CD79A	CD79a molecule, immunoglobulin-associated alpha. (227 aa)
	SH2D6	SH2 domain-containing protein. (105 aa)
	SHC2	SHC (Src homology 2 domain containing) transforming protein 2. (633 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1241 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	LOC102348007	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (392 aa)
	CSK	Tyrosine-protein kinase. (452 aa)
	GAB1	GRB2 associated binding protein 1. (534 aa)
	H3AL82_LATCH	Uncharacterized protein. (245 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	FYB1	FYN binding protein 1. (843 aa)
	SHC3	SHC adaptor protein 3. (630 aa)
	GRAP2	GRB2 related adaptor protein 2. (309 aa)
	SHC1	SHC adaptor protein 1. (602 aa)
	VAV1	Calponin-homology (CH) domain-containing protein. (85 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (673 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	SHC4	SHC adaptor protein 4. (617 aa)
	LOC102366450	Uncharacterized protein. (213 aa)
	LCK	Tyrosine-protein kinase. (512 aa)
	MATK	Tyrosine-protein kinase. (447 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	H3AZT3_LATCH	GRB2 related adaptor protein b. (99 aa)
	LOC102351582	SH2 domain-containing protein. (892 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (516 aa)
	ITK	Tyrosine-protein kinase. (624 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	BTK	Tyrosine-protein kinase. (646 aa)
	LOC102349401	Ig-like domain-containing protein. (181 aa)
	LOC102352712	Protein tyrosine phosphatase non-receptor type 11b. (553 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (519 aa)
	BMX	Tyrosine-protein kinase. (677 aa)
	CD3E	CD3e molecule. (191 aa)
	TEC	Tyrosine-protein kinase. (662 aa)
	LOC102352006	Uncharacterized protein. (163 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLNK	BMX	ENSLACP00000003122	ENSLACP00000021868	B cell linker.	Tyrosine-protein kinase.	0.655
BLNK	BTK	ENSLACP00000003122	ENSLACP00000019537	B cell linker.	Tyrosine-protein kinase.	0.779
BLNK	CD247	ENSLACP00000003122	ENSLACP00000005871	B cell linker.	CD247 molecule.	0.545
BLNK	CD79A	ENSLACP00000003122	ENSLACP00000007655	B cell linker.	CD79a molecule, immunoglobulin-associated alpha.	0.883
BLNK	GRAP2	ENSLACP00000003122	ENSLACP00000012066	B cell linker.	GRB2 related adaptor protein 2.	0.532
BLNK	GRB2	ENSLACP00000003122	ENSLACP00000000662	B cell linker.	Growth factor receptor bound protein 2.	0.906
BLNK	H2ZTT6_LATCH	ENSLACP00000003122	ENSLACP00000000807	B cell linker.	Phosphoinositide phospholipase C.	0.584
BLNK	H3AL82_LATCH	ENSLACP00000003122	ENSLACP00000010403	B cell linker.	Uncharacterized protein.	0.534
BLNK	H3AZT3_LATCH	ENSLACP00000003122	ENSLACP00000015154	B cell linker.	GRB2 related adaptor protein b.	0.532
BLNK	ITK	ENSLACP00000003122	ENSLACP00000016274	B cell linker.	Tyrosine-protein kinase.	0.483
BLNK	LCP2	ENSLACP00000003122	ENSLACP00000003707	B cell linker.	Lymphocyte cytosolic protein 2.	0.486
BLNK	LOC102366450	ENSLACP00000003122	ENSLACP00000013917	B cell linker.	Uncharacterized protein.	0.534
BLNK	LYN	ENSLACP00000003122	ENSLACP00000006462	B cell linker.	Tyrosine-protein kinase.	0.634
BLNK	SOS1	ENSLACP00000003122	ENSLACP00000004382	B cell linker.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.603
BLNK	SOS2	ENSLACP00000003122	ENSLACP00000008627	B cell linker.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.544
BLNK	SYK	ENSLACP00000003122	ENSLACP00000012982	B cell linker.	Tyrosine-protein kinase.	0.825
BLNK	TEC	ENSLACP00000003122	ENSLACP00000023292	B cell linker.	Tyrosine-protein kinase.	0.483
BLNK	VAV1	ENSLACP00000003122	ENSLACP00000012221	B cell linker.	Calponin-homology (CH) domain-containing protein.	0.534
BLNK	VAV2	ENSLACP00000003122	ENSLACP00000021554	B cell linker.	Vav guanine nucleotide exchange factor 2.	0.534
BLNK	VAV3	ENSLACP00000003122	ENSLACP00000001525	B cell linker.	Si:ch73-383g2.1.	0.755