(6 nodes) PI3K p85 subunit, N-terminal SH2 domain, and Angiogenesis involved in wound healing network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102348007	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (392 aa)
	GAB1	GRB2 associated binding protein 1. (534 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAB1	LOC102348007	ENSLACP00000009784	ENSLACP00000008684	GRB2 associated binding protein 1.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.981
GAB1	PIK3CA	ENSLACP00000009784	ENSLACP00000017606	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.952
GAB1	PIK3CB	ENSLACP00000009784	ENSLACP00000014968	GRB2 associated binding protein 1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.961
GAB1	PIK3R1	ENSLACP00000009784	ENSLACP00000015476	GRB2 associated binding protein 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.981
KDR	LOC102348007	ENSLACP00000011126	ENSLACP00000008684	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.967
KDR	PIK3CA	ENSLACP00000011126	ENSLACP00000017606	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.965
KDR	PIK3CB	ENSLACP00000011126	ENSLACP00000014968	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.954
KDR	PIK3R1	ENSLACP00000011126	ENSLACP00000015476	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.967
LOC102348007	GAB1	ENSLACP00000008684	ENSLACP00000009784	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	GRB2 associated binding protein 1.	0.981
LOC102348007	KDR	ENSLACP00000008684	ENSLACP00000011126	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.967
LOC102348007	PIK3CA	ENSLACP00000008684	ENSLACP00000017606	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.984
LOC102348007	PIK3CB	ENSLACP00000008684	ENSLACP00000014968	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.988
LOC102348007	PIK3R1	ENSLACP00000008684	ENSLACP00000015476	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	Phosphoinositide-3-kinase regulatory subunit 1.	0.900
PIK3CA	GAB1	ENSLACP00000017606	ENSLACP00000009784	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	GRB2 associated binding protein 1.	0.952
PIK3CA	KDR	ENSLACP00000017606	ENSLACP00000011126	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.965
PIK3CA	LOC102348007	ENSLACP00000017606	ENSLACP00000008684	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.984
PIK3CA	PIK3CB	ENSLACP00000017606	ENSLACP00000014968	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.966
PIK3CA	PIK3R1	ENSLACP00000017606	ENSLACP00000015476	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphoinositide-3-kinase regulatory subunit 1.	0.994
PIK3CB	GAB1	ENSLACP00000014968	ENSLACP00000009784	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	GRB2 associated binding protein 1.	0.961
PIK3CB	KDR	ENSLACP00000014968	ENSLACP00000011126	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.954