STRINGSTRING
FGFR3 FGFR3 KLB KLB ANOS1 ANOS1 LOC102356182 LOC102356182 FGFR2 FGFR2 FGF8 FGF8 FGF22 FGF22 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 FGF1 FGF1 FGFR1 FGFR1 FGF18 FGF18 FGF7 FGF7 FGF5 FGF5 FGF2 FGF2 FGF23 FGF23 FGFR4 FGFR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFR3Fibroblast growth factor receptor. (778 aa)
KLBKlotho beta. (1027 aa)
ANOS1Anosmin 1. (596 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
FGFR2Fibroblast growth factor receptor. (810 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR1Fibroblast growth factor receptor. (824 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (249 aa)
FGFR4Fibroblast growth factor receptor. (810 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.