(60 nodes) Semaphorin-plexin signaling pathway, and Glycocalyx network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZSG0_LATCH	Sema domain-containing protein. (212 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (794 aa)
	PLXNA3-2	Plexin A3. (1193 aa)
	PLXNB1	Plexin B1. (2146 aa)
	SEMA6B	Sema domain-containing protein; Belongs to the semaphorin family. (911 aa)
	H3A1N4_LATCH	BPTI/Kunitz inhibitor domain-containing protein. (157 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (1059 aa)
	SYPL1	Synaptophysin like 1. (259 aa)
	H3A2E1_LATCH	Plexin_cytopl domain-containing protein. (415 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	H3A3C9_LATCH	Zgc:154142; Belongs to the peptidase S1 family. (902 aa)
	LOC102366847	Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1076 aa)
	H3A6L9_LATCH	Uncharacterized protein. (249 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (772 aa)
	SEMA3D	Semaphorin 3D; Belongs to the semaphorin family. (715 aa)
	H3A8K8_LATCH	Sema domain-containing protein. (2101 aa)
	PKHD1L1	PKHD1 like 1. (4001 aa)
	FOXC1	Forkhead box C1. (471 aa)
	PLXNA3	Sema domain-containing protein. (698 aa)
	SEMA4G	Semaphorin 4G; Belongs to the semaphorin family. (789 aa)
	CDCP2	CUB domain containing protein 2. (514 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (550 aa)
	H3AIX4_LATCH	Uncharacterized protein. (418 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	H3AJV8_LATCH	Beta_helix domain-containing protein. (504 aa)
	LOC102345793	Si:dkeyp-92c9.2. (294 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1565 aa)
	H3AM41_LATCH	G8 domain-containing protein. (1861 aa)
	LOC102366200	Uncharacterized protein; Belongs to the semaphorin family. (627 aa)
	LOC102347877	Uncharacterized protein. (1033 aa)
	PLXND1	Plexin D1. (1875 aa)
	CEMIP	Cell migration inducing hyaluronidase 1. (1336 aa)
	H3AY29_LATCH	Uncharacterized protein. (534 aa)
	MAB21L1	Mab-21 like 1. (359 aa)
	CEMIP2	Cell migration inducing hyaluronidase 2. (1380 aa)
	FARP1	FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1031 aa)
	H3B0J9_LATCH	EGF_CA domain-containing protein. (68 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (929 aa)
	SEMA4A	Sema domain-containing protein; Belongs to the semaphorin family. (758 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (635 aa)
	H3B428_LATCH	Phorbol-ester/DAG-type domain-containing protein. (108 aa)
	H3B672_LATCH	Uncharacterized protein; Belongs to the semaphorin family. (507 aa)
	H3B6V5_LATCH	Sema domain-containing protein; Belongs to the semaphorin family. (329 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (739 aa)
	LOC102361472	Si:dkey-49n23.1; Belongs to the semaphorin family. (750 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (121 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (767 aa)
	ANGPTL7	Angiopoietin like 7. (350 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (325 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1020 aa)
	RND1	Rho family GTPase 1. (321 aa)
	LOC102347479	Zgc:113162. (325 aa)
	LOC102365809	Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
	FAM136A	Family with sequence similarity 136 member A. (138 aa)
	H3BF50_LATCH	Uncharacterized protein; Belongs to the semaphorin family. (733 aa)
	PLXNA2	Plexin A2. (1897 aa)
	LOC102366586	Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPTL7	FOXC1	ENSLACP00000018561	ENSLACP00000006692	Angiopoietin like 7.	Forkhead box C1.	0.508
ANGPTL7	MAB21L1	ENSLACP00000018561	ENSLACP00000015142	Angiopoietin like 7.	Mab-21 like 1.	0.577
ANGPTL7	SEMA3D	ENSLACP00000018561	ENSLACP00000005942	Angiopoietin like 7.	Semaphorin 3D; Belongs to the semaphorin family.	0.623
ARHGEF12	H3A2E1_LATCH	ENSLACP00000010515	ENSLACP00000003812	Rho guanine nucleotide exchange factor 12.	Plexin_cytopl domain-containing protein.	0.415
ARHGEF12	H3A8K8_LATCH	ENSLACP00000010515	ENSLACP00000005979	Rho guanine nucleotide exchange factor 12.	Sema domain-containing protein.	0.567
ARHGEF12	LOC102347877	ENSLACP00000010515	ENSLACP00000012157	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.415
ARHGEF12	LOC102366200	ENSLACP00000010515	ENSLACP00000010997	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein; Belongs to the semaphorin family.	0.456
ARHGEF12	PLXNA2	ENSLACP00000010515	ENSLACP00000021348	Rho guanine nucleotide exchange factor 12.	Plexin A2.	0.415
ARHGEF12	PLXNA3	ENSLACP00000010515	ENSLACP00000006959	Rho guanine nucleotide exchange factor 12.	Sema domain-containing protein.	0.415
ARHGEF12	PLXNA3-2	ENSLACP00000010515	ENSLACP00000002847	Rho guanine nucleotide exchange factor 12.	Plexin A3.	0.415
ARHGEF12	PLXNB1	ENSLACP00000010515	ENSLACP00000002901	Rho guanine nucleotide exchange factor 12.	Plexin B1.	0.567
ARHGEF12	PLXND1	ENSLACP00000010515	ENSLACP00000013783	Rho guanine nucleotide exchange factor 12.	Plexin D1.	0.415
ARHGEF12	RND1	ENSLACP00000010515	ENSLACP00000019147	Rho guanine nucleotide exchange factor 12.	Rho family GTPase 1.	0.688
ARHGEF12	SEMA4D	ENSLACP00000010515	ENSLACP00000004027	Rho guanine nucleotide exchange factor 12.	Semaphorin 4D; Belongs to the semaphorin family.	0.456
CDCP2	CDK5	ENSLACP00000007354	ENSLACP00000009607	CUB domain containing protein 2.	Cyclin dependent kinase 5.	0.437
CDCP2	H3AIX4_LATCH	ENSLACP00000007354	ENSLACP00000009595	CUB domain containing protein 2.	Uncharacterized protein.	0.410
CDCP2	H3AJV8_LATCH	ENSLACP00000007354	ENSLACP00000009929	CUB domain containing protein 2.	Beta_helix domain-containing protein.	0.410
CDCP2	H3AM41_LATCH	ENSLACP00000007354	ENSLACP00000010712	CUB domain containing protein 2.	G8 domain-containing protein.	0.410
CDCP2	PKHD1L1	ENSLACP00000007354	ENSLACP00000006286	CUB domain containing protein 2.	PKHD1 like 1.	0.410
CDK5	CDCP2	ENSLACP00000009607	ENSLACP00000007354	Cyclin dependent kinase 5.	CUB domain containing protein 2.	0.437