(16 nodes) TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, and TNFs bind their physiological receptors network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (122 aa)
	TNFRSF11B	TNF receptor superfamily member 11b. (409 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	LTBR	Lymphotoxin beta receptor. (377 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	LOC102358329	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (161 aa)
	H3AZ94_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
	H3BAI7_LATCH	TNFR-Cys domain-containing protein. (219 aa)
	TNFSF14	TNF_2 domain-containing protein. (238 aa)
	LOC102360854	Uncharacterized protein. (210 aa)
	M3XGJ3_LATCH	TNFR-Cys domain-containing protein. (163 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (465 aa)
	TNFSF12	TNF superfamily member 12; Belongs to the tumor necrosis factor family. (246 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	CD40LG	ENSLACP00000004148	ENSLACP00000017831	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.992
CD40	H3AZ94_LATCH	ENSLACP00000004148	ENSLACP00000014965	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.953
CD40	LOC102358329	ENSLACP00000004148	ENSLACP00000012214	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.556
CD40	LTBR	ENSLACP00000004148	ENSLACP00000008945	TNFR-Cys domain-containing protein.	Lymphotoxin beta receptor.	0.522
CD40	TNFSF11	ENSLACP00000004148	ENSLACP00000009224	TNFR-Cys domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.845
CD40	TNFSF12	ENSLACP00000004148	ENSLACP00000023615	TNFR-Cys domain-containing protein.	TNF superfamily member 12; Belongs to the tumor necrosis factor family.	0.467
CD40	TNFSF13B	ENSLACP00000004148	ENSLACP00000006159	TNFR-Cys domain-containing protein.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.697
CD40	TNFSF14	ENSLACP00000004148	ENSLACP00000019201	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein.	0.602
CD40	TRAF5	ENSLACP00000004148	ENSLACP00000017309	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.891
CD40LG	CD40	ENSLACP00000017831	ENSLACP00000004148	CD40 ligand; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.992
CD40LG	H3AZ94_LATCH	ENSLACP00000017831	ENSLACP00000014965	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.624
CD40LG	H3BAI7_LATCH	ENSLACP00000017831	ENSLACP00000018908	CD40 ligand; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.671
CD40LG	LOC102358329	ENSLACP00000017831	ENSLACP00000012214	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.720
CD40LG	LOC102360854	ENSLACP00000017831	ENSLACP00000021536	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.671
CD40LG	LTA	ENSLACP00000017831	ENSLACP00000007765	CD40 ligand; Belongs to the tumor necrosis factor family.	Lymphotoxin alpha.	0.753
CD40LG	LTBR	ENSLACP00000017831	ENSLACP00000008945	CD40 ligand; Belongs to the tumor necrosis factor family.	Lymphotoxin beta receptor.	0.781
CD40LG	M3XGJ3_LATCH	ENSLACP00000017831	ENSLACP00000021849	CD40 ligand; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.966
CD40LG	TNFRSF11B	ENSLACP00000017831	ENSLACP00000006809	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 11b.	0.671
CD40LG	TNFRSF1B	ENSLACP00000017831	ENSLACP00000023381	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 1B.	0.635
CD40LG	TNFSF11	ENSLACP00000017831	ENSLACP00000009224	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.648